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Click chemistry in peptide-based drug design

Molecules, 2013-08, Vol.18 (8), p.9797-9817

2013

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Peptide Triazole Inhibitors of HIV-1: Hijackers of Env Metastability

Current protein & peptide science, 2023, Vol.24 (1), p.59

2023

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The Case for S2: The Potential Benefits of the S2 Subunit of the SARS-CoV-2 Spike Protein as an Immunogen in Fighting the COVID-19 Pandemic

Frontiers in immunology, 2021-03, Vol.12, p.637651

2021

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Structure-Based Design, Synthesis and Validation of CD4-Mimetic Small Molecule Inhibitors of HIV‑1 Entry: Conversion of a Viral Entry Agonist to an Antagonist

Accounts of chemical research, 2014-04, Vol.47 (4), p.1228-1237

2014

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Altered Env conformational dynamics as a mechanism of resistance to peptide-triazole HIV-1 inactivators

Retrovirology, 2021-10, Vol.18 (1), p.31-31, Article 31

2021

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Lytic Inactivation of Human Immunodeficiency Virus by Dual Engagement of gp120 and gp41 Domains in the Virus Env Protein Trimer

Biochemistry (Easton), 2016-11, Vol.55 (44), p.6100-6114

2016

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Solid-State Nanopore Detection of Protein Complexes: Applications in Healthcare and Protein Kinetics

Small (Weinheim an der Bergstrasse, Germany), 2013-03, Vol.9 (5), p.750-759

2013

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Improved Durability to SARS-CoV-2 Vaccine Immunity following Coimmunization with Molecular Adjuvant Adenosine Deaminase-1

The Journal of immunology (1950), 2022-07, Vol.209 (1), p.118-127

2022

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Pharmacophore variants of the macrocyclic peptide triazole inactivator of HIV-1 Env

Medicinal chemistry research, 2023-07, Vol.32 (7), p.1497-1509

2023

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Affinity Chromatography and Biological Recognition

Chaiken, Irwin

2012

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A Model of Peptide Triazole Entry Inhibitor Binding to HIV‑1 gp120 and the Mechanism of Bridging Sheet Disruption

Biochemistry (Easton), 2013-04, Vol.52 (13), p.2245-2261

2013

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Peptide Triazole Thiol Irreversibly Inactivates Metastable HIV-1 Env by Accessing Conformational Triggers Intrinsic to Virus–Cell Entry

Microorganisms (Basel), 2021-06, Vol.9 (6), p.1286

2021

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Adenosine deaminase augments SARS-CoV-2 specific cellular and humoral responses in aged mouse models of immunization and challenge

Frontiers in immunology, 2023-03, Vol.14, p.1138609-1138609

2023

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Small-Molecule Inhibitors of HIV-1 Entry Block Receptor-Induced Conformational Changes in the Viral Envelope Glycoproteins

Proceedings of the National Academy of Sciences - PNAS, 2004-04, Vol.101 (14), p.5036-5041

2004

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Covalent Conjugation of a Peptide Triazole to HIV‑1 gp120 Enables Intramolecular Binding Site Occupancy

Biochemistry (Easton), 2014-06, Vol.53 (21), p.3403-3414

2014

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Broad-Spectrum Anti-Human Immunodeficiency Virus (HIV) Potential of a Peptide HIV Type 1 Entry Inhibitor

Journal of Virology, 2007-04, Vol.81 (7), p.3645-3648

2007

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Interleukin-5 Receptor Subunit Oligomerization and Rearrangement Revealed by Fluorescence Resonance Energy Transfer Imaging

The Journal of biological chemistry, 2008-05, Vol.283 (19), p.13398-13406

2008

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Antiviral Breadth and Combination Potential of Peptide Triazole HIV-1 Entry Inhibitors

Antimicrobial Agents and Chemotherapy, 2012-02, Vol.56 (2), p.1073-1080

2012

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Chimeric Cyanovirin-MPER Recombinantly Engineered Proteins Cause Cell-Free Virolysis of HIV-1

Antimicrobial Agents and Chemotherapy, 2013-10, Vol.57 (10), p.4743-4750

2013

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HIV-1 ENV gp120 structural determinants for peptide triazole dual receptor site antagonism

Proteins, structure, function, and bioinformatics, 2013-02, Vol.81 (2), p.271-290

2013

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Antibody Binding Is a Dominant Determinant of the Efficiency of Human Immunodeficiency Virus Type 1 Neutralization

Journal of Virology, 2006-11, Vol.80 (22), p.11404-11408

2006

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Click Chemistry on Azidoproline: High-Affinity Dual Antagonist for HIV-1 Envelope Glycoprotein gp120

ChemMedChem, 2006-01, Vol.1 (1), p.54-57

2006

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Stable Exposure of the Coreceptor-Binding Site in a CD4-Independent HIV-1 Envelope Protein

Proceedings of the National Academy of Sciences - PNAS, 1999-05, Vol.96 (11), p.6359-6364

1999

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Introducing metallocene into a triazole peptide conjugate reduces its off-rate and enhances its affinity and antiviral potency for HIV-1 gp120

Journal of molecular recognition, 2009-03, Vol.22 (2), p.169-174

2009

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Click chemistry in peptide-based drug design

Peptide Triazole Inhibitors of HIV-1: Hijackers of Env Metastability

The Case for S2: The Potential Benefits of the S2 Subunit of the SARS-CoV-2 Spike Protein as an Immunogen in Fighting the COVID-19 Pandemic

Structure-Based Design, Synthesis and Validation of CD4-Mimetic Small Molecule Inhibitors of HIV‑1 Entry: Conversion of a Viral Entry Agonist to an Antagonist

Altered Env conformational dynamics as a mechanism of resistance to peptide-triazole HIV-1 inactivators

Lytic Inactivation of Human Immunodeficiency Virus by Dual Engagement of gp120 and gp41 Domains in the Virus Env Protein Trimer

Solid-State Nanopore Detection of Protein Complexes: Applications in Healthcare and Protein Kinetics

Improved Durability to SARS-CoV-2 Vaccine Immunity following Coimmunization with Molecular Adjuvant Adenosine Deaminase-1

Pharmacophore variants of the macrocyclic peptide triazole inactivator of HIV-1 Env

The HIV-1 Env gp120 Inner Domain Shapes the Phe43 Cavity and the CD4 Binding Site

Affinity Chromatography and Biological Recognition

A Model of Peptide Triazole Entry Inhibitor Binding to HIV‑1 gp120 and the Mechanism of Bridging Sheet Disruption

Peptide Triazole Thiol Irreversibly Inactivates Metastable HIV-1 Env by Accessing Conformational Triggers Intrinsic to Virus–Cell Entry

Adenosine deaminase augments SARS-CoV-2 specific cellular and humoral responses in aged mouse models of immunization and challenge

Small-Molecule Inhibitors of HIV-1 Entry Block Receptor-Induced Conformational Changes in the Viral Envelope Glycoproteins

Covalent Conjugation of a Peptide Triazole to HIV‑1 gp120 Enables Intramolecular Binding Site Occupancy

Broad-Spectrum Anti-Human Immunodeficiency Virus (HIV) Potential of a Peptide HIV Type 1 Entry Inhibitor

Interleukin-5 Receptor Subunit Oligomerization and Rearrangement Revealed by Fluorescence Resonance Energy Transfer Imaging

Antiviral Breadth and Combination Potential of Peptide Triazole HIV-1 Entry Inhibitors

Chimeric Cyanovirin-MPER Recombinantly Engineered Proteins Cause Cell-Free Virolysis of HIV-1

HIV-1 ENV gp120 structural determinants for peptide triazole dual receptor site antagonism

Antibody Binding Is a Dominant Determinant of the Efficiency of Human Immunodeficiency Virus Type 1 Neutralization

Click Chemistry on Azidoproline: High-Affinity Dual Antagonist for HIV-1 Envelope Glycoprotein gp120

Stable Exposure of the Coreceptor-Binding Site in a CD4-Independent HIV-1 Envelope Protein

Introducing metallocene into a triazole peptide conjugate reduces its off-rate and enhances its affinity and antiviral potency for HIV-1 gp120

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