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Deoxyadenosine analogs induce programmed cell death in chronic lymphocytic leukemia cells by damaging the DNA and by directly affecting the mitochondria

Blood, 2000-11, Vol.96 (10), p.3537-3543

2000

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Nucleotide Requirements for the in Vitro Activation of the Apoptosis Protein-activating Factor-1-mediated Caspase Pathway

The Journal of biological chemistry, 2000-01, Vol.275 (1), p.29-34

2000

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Induction of an Apoptotic Program in Cell-Free Extracts by 2-Chloro-2′-deoxyadenosine 5′-Triphosphate and Cytochrome c

Proceedings of the National Academy of Sciences - PNAS, 1998-08, Vol.95 (16), p.9567-9571

1998

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Lasting Remissions in Hairy-Cell Leukemia Induced by a Single Infusion of 2-Chlorodeoxyadenosine

The New England journal of medicine, 1990-04, Vol.322 (16), p.1117-1121

1990

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Effect of Antidepressant Switching vs Augmentation on Remission Among Patients With Major Depressive Disorder Unresponsive to Antidepressant Treatment: The VAST-D Randomized Clinical Trial

JAMA : the journal of the American Medical Association, 2017-07, Vol.318 (2), p.132

2017

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EFA (9-β-D-erythrofuranosyladenine) is an effective salvage agent for methylthioadenosine phosphorylase-selective therapy of T-cell acute lymphoblastic leukemia with L-alanosine

Blood, 2006-02, Vol.107 (3), p.898-903

2006

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A methylthioadenosine phosphorylase (MTAP) fusion transcript identifies a new gene on chromosome 9p21 that is frequently deleted in cancer

Oncogene, 2000-11, Vol.19 (50), p.5747-5754

2000

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Rational design, synthesis and structure–activity relationships of antitumor ( E)-2-benzylidene-1-tetralones and ( E)-2-benzylidene-1-indanones

Bioorganic & medicinal chemistry letters, 2000-03, Vol.10 (5), p.487-490

2000

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Use of alanosine as a methylthioadenosine phosphorylase-selective therapy for T-cell acute lymphoblastic leukemia in vitro

Cancer research (Chicago, Ill.), 1999-04, Vol.59 (7), p.1492-1497

1999

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Methylthioadenosine phosphorylase cDNA transfection alters sensitivity to depletion of purine and methionine in A549 lung cancer cells

Cancer research (Chicago, Ill.), 1996-12, Vol.56 (24), p.5653-5658

1996

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Indanocine, a microtubule-binding indanone and a selective inducer of apoptosis in multidrug-resistant cancer cells

JNCI : Journal of the National Cancer Institute, 2000-02, Vol.92 (3), p.217-224

2000

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Homozygous deletions of methylthioadenosine phosphorylase (MTAP) are more frequent than p16INK4A (CDKN2) homozygous deletions in primary non-small cell lung cancers (NSCLC)

Oncogene, 1998-11, Vol.17 (20), p.2669-2675

1998

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Relationship of Deoxycytidine Kinase and Cytoplasmic 5’-Nucleotidase to the Chemotherapeutic Efficacy of 2-Chlorodeoxyadenosine

Blood, 1993-02, Vol.81 (3), p.597-601

1993

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Oral Antilymphocyte Activity and Induction of Apoptosis by 2-Chloro-2'- Arabino-Fluoro-2'-Deoxyadenosine

Proceedings of the National Academy of Sciences - PNAS, 1992-04, Vol.89 (7), p.2970-2974

1992

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Resistance to multiple adenine nucleoside and methionine analogues in mutant murine lymphoma cells with enlarged S-adenosylmethionine pools

Cancer research (Chicago, Ill.), 1986-06, Vol.46 (6), p.2866-2870

1986

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2-Chlorodeoxyadenosine: An Effective New Agent for the Treatment of Chronic Lymphocytic Leukemia

Blood, 1988-09, Vol.72 (3), p.1069-1073

1988

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Potent toxicity of 2-chlorodeoxyadenosine toward human monocytes in vitro and in vivo : a novel approach to immunosuppressive therapy

The Journal of clinical investigation, 1990-11, Vol.86 (5), p.1480-1488

1990

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2-Chlorodeoxyadenosine: An Active Agent in the Treatment of Cutaneous T-Cell Lymphoma

Blood, 1992-08, Vol.80 (3), p.587-592

1992

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DNA strand breaks, NAD metabolism, and programmed cell death

Experimental cell research, 1986-06, Vol.164 (2), p.273-281

1986

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Presence of methylthioadenosine phosphorylase (MTAP) in hematopoietic stem/progenitor cells: its therapeutic implication for MTAP (-) malignancies

Clinical cancer research, 1997-03, Vol.3 (3), p.433-438

1997

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2-Chlorodeoxyadenosine dose escalation in nonhematologic malignancies

Journal of clinical oncology, 1993-04, Vol.11 (4), p.671-678

1993

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Indanocine, a Microtubule-Binding Indanone and a Selective Inducer of Apoptosis inMultidrug-Resistant Cancer Cells

JNCI : Journal of the National Cancer Institute, 2000-02, Vol.92 (3), p.217-224

2000

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Deoxyadenosine analogs induce programmed cell death in chronic lymphocytic leukemia cells by damaging the DNA and by directly affecting the mitochondria

Blood, 2000-11, Vol.96 (10), p.3537-3543

2000

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2-Chlorodeoxyadenosine (2-CdA): A Potent Chemotherapeutic and Immunosuppressive Nucleoside

Leukemia & lymphoma, 1991, Vol.5 (1), p.1-8

1991

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Marrow suppression produced by repeated doses of cladribine

Acta haematologica, 1994, Vol.91 (1), p.10-15

1994

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Deoxyadenosine analogs induce programmed cell death in chronic lymphocytic leukemia cells by damaging the DNA and by directly affecting the mitochondria

Nucleotide Requirements for the in Vitro Activation of the Apoptosis Protein-activating Factor-1-mediated Caspase Pathway

Induction of an Apoptotic Program in Cell-Free Extracts by 2-Chloro-2′-deoxyadenosine 5′-Triphosphate and Cytochrome c

Lasting Remissions in Hairy-Cell Leukemia Induced by a Single Infusion of 2-Chlorodeoxyadenosine

Effect of Antidepressant Switching vs Augmentation on Remission Among Patients With Major Depressive Disorder Unresponsive to Antidepressant Treatment: The VAST-D Randomized Clinical Trial

EFA (9-β-D-erythrofuranosyladenine) is an effective salvage agent for methylthioadenosine phosphorylase-selective therapy of T-cell acute lymphoblastic leukemia with L-alanosine

A methylthioadenosine phosphorylase (MTAP) fusion transcript identifies a new gene on chromosome 9p21 that is frequently deleted in cancer

Rational design, synthesis and structure–activity relationships of antitumor ( E)-2-benzylidene-1-tetralones and ( E)-2-benzylidene-1-indanones

Use of alanosine as a methylthioadenosine phosphorylase-selective therapy for T-cell acute lymphoblastic leukemia in vitro

Methylthioadenosine phosphorylase cDNA transfection alters sensitivity to depletion of purine and methionine in A549 lung cancer cells

Indanocine, a microtubule-binding indanone and a selective inducer of apoptosis in multidrug-resistant cancer cells

Homozygous deletions of methylthioadenosine phosphorylase (MTAP) are more frequent than p16INK4A (CDKN2) homozygous deletions in primary non-small cell lung cancers (NSCLC)

Relationship of Deoxycytidine Kinase and Cytoplasmic 5’-Nucleotidase to the Chemotherapeutic Efficacy of 2-Chlorodeoxyadenosine

Oral Antilymphocyte Activity and Induction of Apoptosis by 2-Chloro-2'- Arabino-Fluoro-2'-Deoxyadenosine

Resistance to multiple adenine nucleoside and methionine analogues in mutant murine lymphoma cells with enlarged S-adenosylmethionine pools

2-Chlorodeoxyadenosine: An Effective New Agent for the Treatment of Chronic Lymphocytic Leukemia

Potent toxicity of 2-chlorodeoxyadenosine toward human monocytes in vitro and in vivo : a novel approach to immunosuppressive therapy

2-Chlorodeoxyadenosine: An Active Agent in the Treatment of Cutaneous T-Cell Lymphoma

DNA strand breaks, NAD metabolism, and programmed cell death

Presence of methylthioadenosine phosphorylase (MTAP) in hematopoietic stem/progenitor cells: its therapeutic implication for MTAP (-) malignancies

2-Chlorodeoxyadenosine dose escalation in nonhematologic malignancies

Indanocine, a Microtubule-Binding Indanone and a Selective Inducer of Apoptosis inMultidrug-Resistant Cancer Cells

Deoxyadenosine analogs induce programmed cell death in chronic lymphocytic leukemia cells by damaging the DNA and by directly affecting the mitochondria

2-Chlorodeoxyadenosine (2-CdA): A Potent Chemotherapeutic and Immunosuppressive Nucleoside

Marrow suppression produced by repeated doses of cladribine

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