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Discovery of CGS 27023A, a Non-Peptidic, Potent, and Orally Active Stromelysin Inhibitor That Blocks Cartilage Degradation in Rabbits

Journal of medicinal chemistry, 1997-08, Vol.40 (16), p.2525-2532

1997

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Identification of Dipeptidyl Nitriles as Potent and Selective Inhibitors of Cathepsin B through Structure-Based Drug Design

Journal of medicinal chemistry, 2001-12, Vol.44 (26), p.4524-4534

2001

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Discovery of 4-((2 S ,4 S )-4-Ethoxy-1-((5-methoxy-7-methyl-1 H -indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases

Journal of medicinal chemistry, 2020-06, Vol.63 (11), p.5697-5722

2020

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Potent Nonimmunosuppressive Cyclophilin Inhibitors With Improved Pharmaceutical Properties and Decreased Transporter Inhibition

Journal of medicinal chemistry, 2014-10, Vol.57 (20), p.8503-8516

2014

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A novel kinase inhibitor establishes a predominant role for protein kinase D as a cardiac class IIa histone deacetylase kinase

FEBS letters, 2010-02, Vol.584 (3), p.631-637

2010

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Discovery and in Vivo Evaluation of Potent Dual CYP11B2 (Aldosterone Synthase) and CYP11B1 Inhibitors

ACS medicinal chemistry letters, 2013-12, Vol.4 (12), p.1203-1207

2013

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Identification of Potent and Selective Amidobipyridyl Inhibitors of Protein Kinase D

Journal of medicinal chemistry, 2010-08, Vol.53 (15), p.5422-5438

2010

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3,5-Diarylazoles as novel and selective inhibitors of protein kinase D

Bioorganic & medicinal chemistry letters, 2011-03, Vol.21 (5), p.1447-1451

2011

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Design and synthesis of an orally active macrocyclic neutral endopeptidase 24.11 inhibitor

Journal of medicinal chemistry, 1993-11, Vol.36 (24), p.3821-3828

1993

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A mechanistic study of the thermal disproportionation reaction of quinone monoketals

Journal of organic chemistry, 1987-11, Vol.52 (24), p.5360-5364

1987

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Nuclear vs. side-chain reactivity in the anodic oxidation of 2-(4-alkylphenoxy)ethanol derivatives. An interesting effect of the 2-hydroxyethyl group

Journal of the Chemical Society. Chemical communications, 1987 (8), p.610-611

1987

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N‑Alkyl Interstitial Spacers and Terminal Pendants Influence the Alkaline Stability of Tetraalkylammonium Cations for Anion Exchange Membrane Fuel Cells

Chemistry of materials, 2016-04, Vol.28 (8), p.2589-2598

2016

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Can the bioturbation activity of the fiddler crab Minuca rapax modify the distribution of microplastics in sediments?

Marine pollution bulletin, 2022-07, Vol.180, p.113798-113798, Article 113798

2022

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Safety and Efficacy of Starting Antiretroviral Therapy in the First Week of Life

Clinical infectious diseases, 2021-02, Vol.72 (3), p.388-393

2021

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Interleukin 6 Blockade With Tocilizumab Diminishes Indices of Inflammation That Are Linked to Mortality in Treated Human Immunodeficiency Virus Infection

Clinical infectious diseases, 2023-07, Vol.77 (2), p.272-279

2023

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Trophic transfer mechanisms of potentially toxic elements from sediment and plant leaves (Rhizophora mangle) to fiddler crabs (Minuca rapax) ()

Marine pollution bulletin, 2023-12, Vol.197, p.115786-115786, Article 115786

2023

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Development and preclinical pharmacology of a novel dCK inhibitor, DI-87

Biochemical pharmacology, 2020-02, Vol.172, p.113742-113742, Article 113742

2020

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Model‐Informed Precision Dosing Guidance of Ethosuximide Developed from a Randomized Controlled Clinical Trial of Childhood Absence Epilepsy

Clinical pharmacology and therapeutics, 2023-08, Vol.114 (2), p.459-469

2023

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Use of Opportunistic Clinical Data and a Population Pharmacokinetic Model to Support Dosing of Clindamycin for Premature Infants to Adolescents

Clinical pharmacology and therapeutics, 2014-10, Vol.96 (4), p.429-437

2014

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Metabolic reprogramming of cancer-associated fibroblasts by TGF-β drives tumor growth: Connecting TGF-β signaling with "Warburg-like" cancer metabolism and L-lactate production

Cell cycle (Georgetown, Tex.), 2012-08, Vol.11 (16), p.3019-3035

2012

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Pharmacokinetics and Pharmacodynamics of Antifungals in Children: Clinical Implications

Drugs (New York, N.Y.), 2014-06, Vol.74 (8), p.891-909

2014

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Population Pharmacokinetic Assessment and Pharmacodynamic Implications of Pediatric Cefepime Dosing for Susceptible-Dose-Dependent Organisms

Antimicrobial agents and chemotherapy, 2016-04, Vol.60 (4), p.2150-2156

2016

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Pharmacokinetics of lopinavir/ritonavir crushed versus whole tablets in children

Journal of acquired immune deficiency syndromes (1999), 2011-12, Vol.58 (4), p.385

2011

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Discovery of CGS 27023A, a Non-Peptidic, Potent, and Orally Active Stromelysin Inhibitor That Blocks Cartilage Degradation in Rabbits

Identification of Dipeptidyl Nitriles as Potent and Selective Inhibitors of Cathepsin B through Structure-Based Drug Design

Discovery of 4-((2 S ,4 S )-4-Ethoxy-1-((5-methoxy-7-methyl-1 H -indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases

Potent Nonimmunosuppressive Cyclophilin Inhibitors With Improved Pharmaceutical Properties and Decreased Transporter Inhibition

The Discovery of ( S)-1-(6-(3-((4-(1-(Cyclopropanecarbonyl)piperidin-4-yl)-2-methylphenyl)amino)-2,3-dihydro-1 H-inden-4-yl)pyridin-2-yl)-5-methyl-1 H-pyrazole-4-carboxylic Acid, a Soluble Guanylate Cyclase Activator Specifically Designed for Topical Ocular Delivery as a Therapy for Glaucoma

A novel kinase inhibitor establishes a predominant role for protein kinase D as a cardiac class IIa histone deacetylase kinase

Discovery and in Vivo Evaluation of Potent Dual CYP11B2 (Aldosterone Synthase) and CYP11B1 Inhibitors

Identification of Potent and Selective Amidobipyridyl Inhibitors of Protein Kinase D

3,5-Diarylazoles as novel and selective inhibitors of protein kinase D

Design and synthesis of an orally active macrocyclic neutral endopeptidase 24.11 inhibitor

The Discovery of (S)‑1-(6-(3-((4-(1-(Cyclopropanecarbonyl)piperidin-4-yl)-2-methylphenyl)amino)-2,3-dihydro‑1H‑inden-4-yl)pyridin-2-yl)-5-methyl‑1H‑pyrazole-4-carboxylic Acid, a Soluble Guanylate Cyclase Activator Specifically Designed for Topical Ocular Delivery as a Therapy for Glaucoma

A mechanistic study of the thermal disproportionation reaction of quinone monoketals

Nuclear vs. side-chain reactivity in the anodic oxidation of 2-(4-alkylphenoxy)ethanol derivatives. An interesting effect of the 2-hydroxyethyl group

N‑Alkyl Interstitial Spacers and Terminal Pendants Influence the Alkaline Stability of Tetraalkylammonium Cations for Anion Exchange Membrane Fuel Cells

Can the bioturbation activity of the fiddler crab Minuca rapax modify the distribution of microplastics in sediments?

Safety and Efficacy of Starting Antiretroviral Therapy in the First Week of Life

Interleukin 6 Blockade With Tocilizumab Diminishes Indices of Inflammation That Are Linked to Mortality in Treated Human Immunodeficiency Virus Infection

Trophic transfer mechanisms of potentially toxic elements from sediment and plant leaves (Rhizophora mangle) to fiddler crabs (Minuca rapax) ()

Development and preclinical pharmacology of a novel dCK inhibitor, DI-87

Model‐Informed Precision Dosing Guidance of Ethosuximide Developed from a Randomized Controlled Clinical Trial of Childhood Absence Epilepsy

Use of Opportunistic Clinical Data and a Population Pharmacokinetic Model to Support Dosing of Clindamycin for Premature Infants to Adolescents

Metabolic reprogramming of cancer-associated fibroblasts by TGF-β drives tumor growth: Connecting TGF-β signaling with "Warburg-like" cancer metabolism and L-lactate production

Pharmacokinetics and Pharmacodynamics of Antifungals in Children: Clinical Implications

Population Pharmacokinetic Assessment and Pharmacodynamic Implications of Pediatric Cefepime Dosing for Susceptible-Dose-Dependent Organisms

Pharmacokinetics of lopinavir/ritonavir crushed versus whole tablets in children

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