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Delineating the role of cooperativity in the design of potent PROTACs for BTK

Proceedings of the National Academy of Sciences - PNAS, 2018-07, Vol.115 (31), p.E7285-E7292

2018

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Snapshots and ensembles of BTK and cIAP1 protein degrader ternary complexes

Nature chemical biology, 2021-02, Vol.17 (2), p.152-160

2021

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A covalent BTK ternary complex compatible with targeted protein degradation

Nature communications, 2023-03, Vol.14 (1), p.1189-1189, Article 1189

2023

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Protein-induced photophysical changes to the amyloid indicator dye thioflavin T

Proceedings of the National Academy of Sciences - PNAS, 2010-09, Vol.107 (39), p.16863-16868

2010

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SPOP Promotes Tumorigenesis by Acting as a Key Regulatory Hub in Kidney Cancer

Cancer cell, 2014-04, Vol.25 (4), p.455-468

2014

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Structural regulation of cullin-RING ubiquitin ligase complexes

Current opinion in structural biology, 2011-04, Vol.21 (2), p.257-264

2011

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Targeted protein degradation: expanding the toolbox

Nature reviews. Drug discovery, 2019-12, Vol.18 (12), p.949-963

2019

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Probing the enzyme kinetics, allosteric modulation and activation of α1- and α2-subunit-containing AMP-activated protein kinase (AMPK) heterotrimeric complexes by pharmacological and physiological activators

Biochemical journal, 2016-03, Vol.473 (5), p.581-592

2016

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A regulatable switch mediates self-association in an immunoglobulin fold

Nature structural & molecular biology, 2008-09, Vol.15 (9), p.965-971

2008

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Snapshots and ensembles of BTK and cIAP1 protein degrader ternary complexes

Nature chemical biology, 2021-02, Vol.17 (2), p.152

2021

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Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases

Molecular cell, 2009-10, Vol.36 (1), p.39-50

2009

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Perspectives on the development of first-in-class protein degraders

Future medicinal chemistry, 2021-07, Vol.13 (14), p.1203-1226

2021

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A chemical probe to modulate human GID4 Pro/N-degron interactions

Nature chemical biology, 2024-09, Vol.20 (9), p.1164-1175

2024

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Metal binding sheds light on mechanisms of amyloid assembly

Prion, 2009-01, Vol.3 (1), p.1-4

2009

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Structure and Regulation of AMPK

AMP-activated Protein Kinase, 2016, Vol.107, p.3-22

2016

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Structural basis for CCR6 modulation by allosteric antagonists

Nature communications, 2024-08, Vol.15 (1), p.7574-13, Article 7574

2024

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Acyl Glucuronide Metabolites of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1 H-indole-3-carboxylic Acid (PF-06409577) and Related Indole-3-carboxylic Acid Derivatives are Direct Activators of Adenosine Monophosphate-Activated Protein Kinase (AMPK)

Journal of medicinal chemistry, 2018-08, Vol.61 (16), p.7273-7288

2018

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Chemical tools for the Gid4 subunit of the human E3 ligase C-terminal to LisH (CTLH) degradation complex

RSC medicinal chemistry, 2024-03, Vol.15 (3), p.166-171

2024

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Activation of AMP-Activated Protein Kinase Revealed by Hydrogen/Deuterium Exchange Mass Spectrometry

Structure (London), 2013-11, Vol.21 (11), p.1942-1953

2013

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Optimization of Metabolic and Renal Clearance in a Series of Indole Acid Direct Activators of 5′-Adenosine Monophosphate-Activated Protein Kinase (AMPK)

Journal of medicinal chemistry, 2018-03, Vol.61 (6), p.2372-2383

2018

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A RING E3-substrate complex poised for ubiquitin-like protein transfer: structural insights into cullin-RING ligases

Nature structural & molecular biology, 2011-08, Vol.18 (8), p.947-949

2011

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Biophysical Interactions of Direct AMPK Activators

Methods in molecular biology (Clifton, N.J.), 2018-01, Vol.1732, p.29

2018

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Formation of a Stable Oligomer of β-2 Microglobulin Requires only Transient Encounter with Cu(II)

Journal of molecular biology, 2007-03, Vol.367 (1), p.1-7

2007

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Delineating the role of cooperativity in the design of potent PROTACs for BTK

Snapshots and ensembles of BTK and cIAP1 protein degrader ternary complexes

Activation of Skeletal Muscle AMPK Promotes Glucose Disposal and Glucose Lowering in Non-human Primates and Mice

Structural Basis for AMPK Activation: Natural and Synthetic Ligands Regulate Kinase Activity from Opposite Poles by Different Molecular Mechanisms

A covalent BTK ternary complex compatible with targeted protein degradation

Protein-induced photophysical changes to the amyloid indicator dye thioflavin T

SPOP Promotes Tumorigenesis by Acting as a Key Regulatory Hub in Kidney Cancer

Structural regulation of cullin-RING ubiquitin ligase complexes

Targeted protein degradation: expanding the toolbox

Probing the enzyme kinetics, allosteric modulation and activation of α1- and α2-subunit-containing AMP-activated protein kinase (AMPK) heterotrimeric complexes by pharmacological and physiological activators

A regulatable switch mediates self-association in an immunoglobulin fold

Snapshots and ensembles of BTK and cIAP1 protein degrader ternary complexes

Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases

Perspectives on the development of first-in-class protein degraders

A chemical probe to modulate human GID4 Pro/N-degron interactions

Metal binding sheds light on mechanisms of amyloid assembly

Structure and Regulation of AMPK

Structural basis for CCR6 modulation by allosteric antagonists

Acyl Glucuronide Metabolites of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1 H-indole-3-carboxylic Acid (PF-06409577) and Related Indole-3-carboxylic Acid Derivatives are Direct Activators of Adenosine Monophosphate-Activated Protein Kinase (AMPK)

Chemical tools for the Gid4 subunit of the human E3 ligase C-terminal to LisH (CTLH) degradation complex

Activation of AMP-Activated Protein Kinase Revealed by Hydrogen/Deuterium Exchange Mass Spectrometry

Optimization of Metabolic and Renal Clearance in a Series of Indole Acid Direct Activators of 5′-Adenosine Monophosphate-Activated Protein Kinase (AMPK)

A RING E3-substrate complex poised for ubiquitin-like protein transfer: structural insights into cullin-RING ligases

Biophysical Interactions of Direct AMPK Activators

Formation of a Stable Oligomer of β-2 Microglobulin Requires only Transient Encounter with Cu(II)

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