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The indenoisoquinoline noncamptothecin topoisomerase I inhibitors: update and perspectives

Molecular cancer therapeutics, 2009-05, Vol.8 (5), p.1008-1014

2009

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Indenoisoquinoline Topoisomerase Inhibitors Strongly Bind and Stabilize the MYC Promoter G‑Quadruplex and Downregulate MYC

Journal of the American Chemical Society, 2019-07, Vol.141 (28), p.11059-11070

2019

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Design and Synthesis of Indenoisoquinolines Targeting Topoisomerase I and Other Biological Macromolecules for Cancer Chemotherapy

Journal of medicinal chemistry, 2021-12, Vol.64 (24), p.17572-17600

Cushman, Mark

2021

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Antibacterial Evaluation of Synthetic Thiazole Compounds In Vitro and In Vivo in a Methicillin-Resistant Staphylococcus aureus (MRSA) Skin Infection Mouse Model

PloS one, 2015-11, Vol.10 (11), p.e0142321

2015

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Anti-biofilm activity and synergism of novel thiazole compounds with glycopeptide antibiotics against multidrug-resistant staphylococci

Journal of antibiotics, 2015-04, Vol.68 (4), p.259-266

2015

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Structures of Three Classes of Anticancer Agents Bound to the Human Topoisomerase I−DNA Covalent Complex

Geochimica et cosmochimica acta, 2005-04, Vol.48 (7), p.2336-2345

2005

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MAIT recognition of a stimulatory bacterial antigen bound to MR1

The Journal of immunology (1950), 2013-11, Vol.191 (10), p.5268-5277

2013

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Phenylthiazole Antibacterial Agents Targeting Cell Wall Synthesis Exhibit Potent Activity in Vitro and in Vivo against Vancomycin-Resistant Enterococci

Journal of medicinal chemistry, 2017-03, Vol.60 (6), p.2425-2438

2017

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Selective Synthesis and Biological Evaluation of Sulfate-Conjugated Resveratrol Metabolites

Journal of medicinal chemistry, 2010-07, Vol.53 (13), p.5033-5043

2010

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Antibacterial Characterization of Novel Synthetic Thiazole Compounds against Methicillin-Resistant Staphylococcus pseudintermedius

PloS one, 2015-06, Vol.10 (6), p.e0130385

2015

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Design, Synthesis, and Evaluation of Dibenzo[c,h][1,6]naphthyridines as Topoisomerase I Inhibitors and Potential Anticancer Agents

Journal of medicinal chemistry, 2010-12, Vol.53 (24), p.8716-8726

2010

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Novel Fluoroindenoisoquinoline Non-Camptothecin Topoisomerase I Inhibitors

Molecular cancer therapeutics, 2018-08, Vol.17 (8), p.1694-1704

2018

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Discovery of Potent Indenoisoquinoline Topoisomerase I Poisons Lacking the 3‑Nitro Toxicophore

Journal of medicinal chemistry, 2015-05, Vol.58 (9), p.3997-4015

2015

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Optimization of the Indenone Ring of Indenoisoquinoline Topoisomerase I Inhibitors

Journal of medicinal chemistry, 2007-09, Vol.50 (18), p.4388-4404

2007

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Synthesis and Biological Evaluation of the First Dual Tyrosyl-DNA Phosphodiesterase I (Tdp1)–Topoisomerase I (Top1) Inhibitors

Journal of medicinal chemistry, 2012-05, Vol.55 (9), p.4457-4478

2012

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DUPA Conjugation of a Cytotoxic Indenoisoquinoline Topoisomerase I Inhibitor for Selective Prostate Cancer Cell Targeting

Journal of medicinal chemistry, 2015-04, Vol.58 (7), p.3094-3103

2015

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The tamoxifen metabolite norendoxifen is a potent and selective inhibitor of aromatase (CYP19) and a potential lead compound for novel therapeutic agents

Breast cancer research and treatment, 2012-05, Vol.133 (1), p.99-109

2012

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Design, Synthesis, and Biological Evaluation of Thiazoles Targeting Flavivirus Envelope Proteins

Journal of medicinal chemistry, 2011-03, Vol.54 (6), p.1704-1714

2011

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Design, Synthesis, and Biological Evaluation of Antiviral Agents Targeting Flavivirus Envelope Proteins

Journal of medicinal chemistry, 2008-08, Vol.51 (15), p.4660-4671

2008

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Novel Indenoisoquinolines NSC 725776 and NSC 724998 Produce Persistent Topoisomerase I Cleavage Complexes and Overcome Multidrug Resistance

Cancer research (Chicago, Ill.), 2007-11, Vol.67 (21), p.10397-10405

2007

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Characterization and structure-activity relationships of indenoisoquinoline-derived topoisomerase I inhibitors in unsilencing the dormant Ube3a gene associated with Angelman syndrome

Molecular autism, 2018-08, Vol.9 (1), p.45-10, Article 45

2018

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Mechanistic Insights on Riboflavin Synthase Inspired by Selective Binding of the 6,7-Dimethyl-8-ribityllumazine Exomethylene Anion

Journal of the American Chemical Society, 2010-03, Vol.132 (9), p.2983-2990

2010

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Discovery of efficient stimulators for adult hippocampal neurogenesis based on scaffolds in dragon's blood

European journal of medicinal chemistry, 2017-08, Vol.136, p.382-392

2017

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A novel norindenoisoquinoline structure reveals a common interfacial inhibitor paradigm for ternary trapping of the topoisomerase I-DNA covalent complex

Molecular cancer therapeutics, 2006-02, Vol.5 (2), p.287-295

2006

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Design, synthesis and structure-bactericidal activity relationships of novel 9-oxime ketolides and reductive epimers of acylides

Bioorganic & medicinal chemistry letters, 2017-04, Vol.27 (7), p.1513-1524

2017

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The indenoisoquinoline noncamptothecin topoisomerase I inhibitors: update and perspectives

Indenoisoquinoline Topoisomerase Inhibitors Strongly Bind and Stabilize the MYC Promoter G‑Quadruplex and Downregulate MYC

Design and Synthesis of Indenoisoquinolines Targeting Topoisomerase I and Other Biological Macromolecules for Cancer Chemotherapy

Antibacterial Evaluation of Synthetic Thiazole Compounds In Vitro and In Vivo in a Methicillin-Resistant Staphylococcus aureus (MRSA) Skin Infection Mouse Model

Anti-biofilm activity and synergism of novel thiazole compounds with glycopeptide antibiotics against multidrug-resistant staphylococci

Structures of Three Classes of Anticancer Agents Bound to the Human Topoisomerase I−DNA Covalent Complex

MAIT recognition of a stimulatory bacterial antigen bound to MR1

Phenylthiazole Antibacterial Agents Targeting Cell Wall Synthesis Exhibit Potent Activity in Vitro and in Vivo against Vancomycin-Resistant Enterococci

Selective Synthesis and Biological Evaluation of Sulfate-Conjugated Resveratrol Metabolites

Antibacterial Characterization of Novel Synthetic Thiazole Compounds against Methicillin-Resistant Staphylococcus pseudintermedius

Design, Synthesis, and Evaluation of Dibenzo[c,h][1,6]naphthyridines as Topoisomerase I Inhibitors and Potential Anticancer Agents

Novel Fluoroindenoisoquinoline Non-Camptothecin Topoisomerase I Inhibitors

Discovery of Potent Indenoisoquinoline Topoisomerase I Poisons Lacking the 3‑Nitro Toxicophore

Optimization of the Indenone Ring of Indenoisoquinoline Topoisomerase I Inhibitors

Synthesis and Biological Evaluation of the First Dual Tyrosyl-DNA Phosphodiesterase I (Tdp1)–Topoisomerase I (Top1) Inhibitors

DUPA Conjugation of a Cytotoxic Indenoisoquinoline Topoisomerase I Inhibitor for Selective Prostate Cancer Cell Targeting

The tamoxifen metabolite norendoxifen is a potent and selective inhibitor of aromatase (CYP19) and a potential lead compound for novel therapeutic agents

Design, Synthesis, and Biological Evaluation of Thiazoles Targeting Flavivirus Envelope Proteins

Design, Synthesis, and Biological Evaluation of Antiviral Agents Targeting Flavivirus Envelope Proteins

Novel Indenoisoquinolines NSC 725776 and NSC 724998 Produce Persistent Topoisomerase I Cleavage Complexes and Overcome Multidrug Resistance

Characterization and structure-activity relationships of indenoisoquinoline-derived topoisomerase I inhibitors in unsilencing the dormant Ube3a gene associated with Angelman syndrome

Mechanistic Insights on Riboflavin Synthase Inspired by Selective Binding of the 6,7-Dimethyl-8-ribityllumazine Exomethylene Anion

Discovery of efficient stimulators for adult hippocampal neurogenesis based on scaffolds in dragon's blood

A novel norindenoisoquinoline structure reveals a common interfacial inhibitor paradigm for ternary trapping of the topoisomerase I-DNA covalent complex

Design, synthesis and structure-bactericidal activity relationships of novel 9-oxime ketolides and reductive epimers of acylides

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