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Ushering in the next generation of precision trials for pediatric cancer

Science (American Association for the Advancement of Science), 2019-03, Vol.363 (6432), p.1175-1181

2019

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Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors

Proceedings of the National Academy of Sciences - PNAS, 2015-08, Vol.112 (32), p.E4410-E4417

2015

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Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition

Nature chemical biology, 2016-10, Vol.12 (10), p.779

2016

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Identification of 2-amino-5-aryl-pyrazines as inhibitors of human lactate dehydrogenase

Bioorganic & medicinal chemistry letters, 2013-10, Vol.23 (20), p.5533-5539

2013

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Sensitivity to splicing modulation of BCL2 family genes defines cancer therapeutic strategies for splicing modulators

Nature communications, 2019-01, Vol.10 (1), p.137-137, Article 137

2019

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Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A-SF3b complex

Nature communications, 2017-05, Vol.8 (1), p.15522-15522, Article 15522

2017

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Evasion of immunosurveillance by genomic alterations of PPARγ/RXRα in bladder cancer

Nature communications, 2017-07, Vol.8 (1), p.103-14, Article 103

2017

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Molecular profiling identifies targeted therapy opportunities in pediatric solid cancer

Nature medicine, 2022-08, Vol.28 (8), p.1581-1589

2022

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An Integrated Genomic Screen Identifies LDHB as an Essential Gene for Triple-Negative Breast Cancer

Cancer research (Chicago, Ill.), 2012-11, Vol.72 (22), p.5812-5823

2012

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Identification of substituted 2-thio-6-oxo-1,6-dihydropyrimidines as inhibitors of human lactate dehydrogenase

Bioorganic & medicinal chemistry letters, 2013-06, Vol.23 (11), p.3186-3194

2013

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Structure-based optimization of hydroxylactam as potent, cell-active inhibitors of lactate dehydrogenase

Bioorganic & medicinal chemistry letters, 2022-03, Vol.59 (C), p.128576-128576, Article 128576

2022

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Cell Active Hydroxylactam Inhibitors of Human Lactate Dehydrogenase with Oral Bioavailability in Mice

ACS medicinal chemistry letters, 2016-10, Vol.7 (10), p.896-901

2016

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Identification of substituted 3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase

Bioorganic & medicinal chemistry letters, 2014-08, Vol.24 (16), p.3764-3771

2014

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Spatial and temporal patterns of ERK signaling during mouse embryogenesis

Development (Cambridge), 2003-10, Vol.130 (19), p.4527-4537

2003

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Identification of 3,6-disubstituted dihydropyrones as inhibitors of human lactate dehydrogenase

Bioorganic & medicinal chemistry letters, 2014-12, Vol.24 (24), p.5683-5687

2014

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Author Correction: Evasion of immunosurveillance by genomic alterations of PPARγ/RXRα in bladder cancer

Nature communications, 2019-06, Vol.10 (1), p.2527-2527, Article 2527

2019

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Optimization of 5-(2,6-dichlorophenyl)-3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase

Bioorganic & medicinal chemistry letters, 2015-01, Vol.25 (1), p.75-82

2015

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A high-content cellular senescence screen identifies candidate tumor suppressors, including EPHA3

Cell cycle (Georgetown, Tex.), 2013-02, Vol.12 (4), p.625-634

2013

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Characterization of Mouse Rsk4 as an Inhibitor of Fibroblast Growth Factor-RAS-Extracellular Signal-Regulated Kinase Signaling

Molecular and Cellular Biology, 2004-05, Vol.24 (10), p.4255-4266

2004

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Chaperone-Facilitated Copper Binding is a Property Common to Several Classes of Familial Amyotrophic Lateral Sclerosis-Linked Superoxide Dismutase Mutants

Proceedings of the National Academy of Sciences - PNAS, 1998-05, Vol.95 (11), p.6361-6366

1998

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Variation in the Biochemical/Biophysical Properties of Mutant Superoxide Dismutase 1 Enzymes and the Rate of Disease Progression in Familial Amyotrophic Lateral Sclerosis Kindreds

Human molecular genetics, 1999-08, Vol.8 (8), p.1451-1460

1999

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Characterizing the landscape of genomic variants in high-risk pediatric osteosarcoma

Journal of clinical oncology, 2020-05, Vol.38 (15_suppl), p.11530-11530

2020

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The Copper Chaperone CCS Is Abundant in Neurons and Astrocytes in Human and Rodent Brain

Journal of neurochemistry, 1999-01, Vol.72 (1), p.422-429

1999

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Ushering in the next generation of precision trials for pediatric cancer

Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors

Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition

Cancer-Associated SF3B1 Hotspot Mutations Induce Cryptic 3′ Splice Site Selection through Use of a Different Branch Point

Identification of 2-amino-5-aryl-pyrazines as inhibitors of human lactate dehydrogenase

Sensitivity to splicing modulation of BCL2 family genes defines cancer therapeutic strategies for splicing modulators

Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A-SF3b complex

Evasion of immunosurveillance by genomic alterations of PPARγ/RXRα in bladder cancer

Molecular profiling identifies targeted therapy opportunities in pediatric solid cancer

An Integrated Genomic Screen Identifies LDHB as an Essential Gene for Triple-Negative Breast Cancer

Identification of substituted 2-thio-6-oxo-1,6-dihydropyrimidines as inhibitors of human lactate dehydrogenase

Structure-based optimization of hydroxylactam as potent, cell-active inhibitors of lactate dehydrogenase

Cell Active Hydroxylactam Inhibitors of Human Lactate Dehydrogenase with Oral Bioavailability in Mice

Identification of substituted 3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase

Spatial and temporal patterns of ERK signaling during mouse embryogenesis

Identification of 3,6-disubstituted dihydropyrones as inhibitors of human lactate dehydrogenase

Author Correction: Evasion of immunosurveillance by genomic alterations of PPARγ/RXRα in bladder cancer

Optimization of 5-(2,6-dichlorophenyl)-3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase

A high-content cellular senescence screen identifies candidate tumor suppressors, including EPHA3

Germline Sequencing Improves Tumor-Only Sequencing Interpretation in a Precision Genomic Study of Patients With Pediatric Solid Tumor

Characterization of Mouse Rsk4 as an Inhibitor of Fibroblast Growth Factor-RAS-Extracellular Signal-Regulated Kinase Signaling

Chaperone-Facilitated Copper Binding is a Property Common to Several Classes of Familial Amyotrophic Lateral Sclerosis-Linked Superoxide Dismutase Mutants

Variation in the Biochemical/Biophysical Properties of Mutant Superoxide Dismutase 1 Enzymes and the Rate of Disease Progression in Familial Amyotrophic Lateral Sclerosis Kindreds

Characterizing the landscape of genomic variants in high-risk pediatric osteosarcoma

The Copper Chaperone CCS Is Abundant in Neurons and Astrocytes in Human and Rodent Brain

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