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Interaction of DWORF with SERCA and PLB as determined by EPR spectroscopy

Biochemical and biophysical research communications, 2023-02, Vol.645, p.97-102

2023

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The CaMKII inhibitor KN93-calmodulin interaction and implications for calmodulin tuning of NaV1.5 and RyR2 function

Cell calcium (Edinburgh), 2019-09, Vol.82 (9), p.102063-102063, Article 102063

2019

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Oxidation of ryanodine receptor (RyR) and calmodulin enhance Ca release and pathologically alter, RyR structure and calmodulin affinity

Journal of molecular and cellular cardiology, 2015-08, Vol.85, p.240-248

2015

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Kinetics and mapping of Ca-driven calmodulin conformations on skeletal and cardiac muscle ryanodine receptors

Nature communications, 2024-06, Vol.15 (1), p.5120-13, Article 5120

2024

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CaMKII-dependent phosphorylation of RyR2 promotes targetable pathological RyR2 conformational shift

Journal of molecular and cellular cardiology, 2016-09, Vol.98, p.62-72

2016

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The transmembrane peptide DWORF activates SERCA2a via dual mechanisms

The Journal of biological chemistry, 2021-01, Vol.296, p.100412, Article 100412

2021

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Unnatural verticilide enantiomer inhibits type 2 ryanodine receptor-mediated calcium leak and is antiarrhythmic

Proceedings of the National Academy of Sciences - PNAS, 2019-03, Vol.116 (11), p.4810-4815

2019

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Divergent Regulation of Ryanodine Receptor 2 Calcium Release Channels by Arrhythmogenic Human Calmodulin Missense Mutants

Circulation research, 2014-03, Vol.114 (7), p.1114-1124

2014

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Resolved Structural States of Calmodulin in Regulation of Skeletal Muscle Calcium Release

Biophysical journal, 2020-03, Vol.118 (5), p.1090-1100

2020

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RyR1-targeted drug discovery pipeline integrating FRET-based high-throughput screening and human myofiber dynamic Ca2+ assays

Scientific reports, 2020-02, Vol.10 (1), p.1791-1791, Article 1791

2020

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Kinetics and mapping of calcium-driven calmodulin conformations on ryanodine receptors

Biophysical journal, 2023-02, Vol.122 (3), p.239a-239a

2023

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Crystal structures of ryanodine receptor SPRY1 and tandem-repeat domains reveal a critical FKBP12 binding determinant

Nature communications, 2015-08, Vol.6 (1), p.7947-7947, Article 7947

2015

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Synergistic FRET assays for drug discovery targeting RyR2 channels

Journal of molecular and cellular cardiology, 2022-07, Vol.168, p.13-23

2022

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Fluorescence lifetime FRET assay for live-cell high-throughput screening of the cardiac SERCA pump yields multiple classes of small-molecule allosteric modulators

Scientific reports, 2023-07, Vol.13 (1), p.10673-10673, Article 10673

2023

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CaMKIIδ post-translational modifications increase affinity for calmodulin inside cardiac ventricular myocytes

Journal of molecular and cellular cardiology, 2021-12, Vol.161, p.53-61

2021

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Regulation of cardiac calcium signaling by newly identified calcium pump modulators

Biochemical and biophysical research communications, 2023-12, Vol.685, p.149136-149136, Article 149136

2023

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Molecular Mechanism of a FRET Biosensor for the Cardiac Ryanodine Receptor Pathologically Leaky State

International journal of molecular sciences, 2023-08, Vol.24 (16), p.12547

2023

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Cardiac myocyte Z-line calmodulin is mainly RyR2-bound, and reduction is arrhythmogenic and occurs in heart failure

Circulation research, 2014-01, Vol.114 (2), p.295-306

2014

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Kinetics of FKBP12.6 Binding to Ryanodine Receptors in Permeabilized Cardiac Myocytes and Effects on Ca Sparks

Circulation research, 2010-06, Vol.106 (11), p.1743-1752

2010

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FRET Detection of Calmodulin Binding to the Cardiac RyR2 Calcium Release Channel

Biophysical journal, 2011-11, Vol.101 (9), p.2170-2177

2011

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The selective RyR2 inhibitor ent-verticilide suppresses atrial fibrillation susceptibility caused by Pitx2 deficiency

Journal of molecular and cellular cardiology, 2023-07, Vol.180, p.1-9

2023

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A Large-Scale High-Throughput Screen for Modulators of SERCA Activity

Biomolecules (Basel, Switzerland), 2022-11, Vol.12 (12), p.1789

2022

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New N-aryl-N-alkyl-thiophene-2-carboxamide compound enhances intracellular Ca2+ dynamics by increasing SERCA2a Ca2+ pumping

Biophysical journal, 2023-01, Vol.122 (2), p.386-396

2023

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Structural basis for allosteric control of the SERCA-Phospholamban membrane complex by Ca2+ and phosphorylation

eLife, 2021-05, Vol.10

2021

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ent -Verticilide B1 Inhibits Type 2 Ryanodine Receptor Channels and is Antiarrhythmic in Casq2 -/- Mice

Molecular pharmacology, 2024-03, Vol.105 (3), p.194

2024

Volltextzugriff (PDF)

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Interaction of DWORF with SERCA and PLB as determined by EPR spectroscopy

The CaMKII inhibitor KN93-calmodulin interaction and implications for calmodulin tuning of NaV1.5 and RyR2 function

Oxidation of ryanodine receptor (RyR) and calmodulin enhance Ca release and pathologically alter, RyR structure and calmodulin affinity

Kinetics and mapping of Ca-driven calmodulin conformations on skeletal and cardiac muscle ryanodine receptors

CaMKII-dependent phosphorylation of RyR2 promotes targetable pathological RyR2 conformational shift

The transmembrane peptide DWORF activates SERCA2a via dual mechanisms

Unnatural verticilide enantiomer inhibits type 2 ryanodine receptor-mediated calcium leak and is antiarrhythmic

Divergent Regulation of Ryanodine Receptor 2 Calcium Release Channels by Arrhythmogenic Human Calmodulin Missense Mutants

Resolved Structural States of Calmodulin in Regulation of Skeletal Muscle Calcium Release

RyR1-targeted drug discovery pipeline integrating FRET-based high-throughput screening and human myofiber dynamic Ca2+ assays

Kinetics and mapping of calcium-driven calmodulin conformations on ryanodine receptors

Crystal structures of ryanodine receptor SPRY1 and tandem-repeat domains reveal a critical FKBP12 binding determinant

Synergistic FRET assays for drug discovery targeting RyR2 channels

Fluorescence lifetime FRET assay for live-cell high-throughput screening of the cardiac SERCA pump yields multiple classes of small-molecule allosteric modulators

CaMKIIδ post-translational modifications increase affinity for calmodulin inside cardiac ventricular myocytes

Regulation of cardiac calcium signaling by newly identified calcium pump modulators

Molecular Mechanism of a FRET Biosensor for the Cardiac Ryanodine Receptor Pathologically Leaky State

Cardiac myocyte Z-line calmodulin is mainly RyR2-bound, and reduction is arrhythmogenic and occurs in heart failure

Kinetics of FKBP12.6 Binding to Ryanodine Receptors in Permeabilized Cardiac Myocytes and Effects on Ca Sparks

FRET Detection of Calmodulin Binding to the Cardiac RyR2 Calcium Release Channel

The selective RyR2 inhibitor ent-verticilide suppresses atrial fibrillation susceptibility caused by Pitx2 deficiency

A Large-Scale High-Throughput Screen for Modulators of SERCA Activity

New N-aryl-N-alkyl-thiophene-2-carboxamide compound enhances intracellular Ca2+ dynamics by increasing SERCA2a Ca2+ pumping

Structural basis for allosteric control of the SERCA-Phospholamban membrane complex by Ca2+ and phosphorylation

ent -Verticilide B1 Inhibits Type 2 Ryanodine Receptor Channels and is Antiarrhythmic in Casq2 -/- Mice

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