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Identifying the molecular target sites for CFTR potentiators GLPG1837 and VX-770

The Journal of general physiology, 2019-07, Vol.151 (7), p.912-928

2019

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General Strategy to Humanize a Camelid Single-domain Antibody and Identification of a Universal Humanized Nanobody Scaffold

The Journal of biological chemistry, 2009-01, Vol.284 (5), p.3273-3284

2009

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A common mechanism for CFTR potentiators

The Journal of general physiology, 2017-12, Vol.149 (12), p.1105-1118

2017

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Preclinical characterization of GLPG0634, a selective inhibitor of JAK1, for the treatment of inflammatory diseases

The Journal of immunology (1950), 2013-10, Vol.191 (7), p.3568-3577

2013

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Disulfide Bond Introduction for General Stabilization of Immunoglobulin Heavy-Chain Variable Domains

Journal of molecular biology, 2008-03, Vol.377 (2), p.478-488

2008

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Molecular Basis for the Preferential Cleft Recognition by Dromedary Heavy-Chain Antibodies

Proceedings of the National Academy of Sciences - PNAS, 2006-03, Vol.103 (12), p.4586-4591

2006

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Discovery of 9‑Cyclopropylethynyl-2-((S)‑1-[1,4]dioxan-2-ylmethoxy)-6,7-dihydropyrimido[6,1‑a]isoquinolin-4-one (GLPG1205), a Unique GPR84 Negative Allosteric Modulator Undergoing Evaluation in a Phase II Clinical Trial

Journal of medicinal chemistry, 2020-11, Vol.63 (22), p.13526-13545

2020

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A Novel, Broad-Spectrum Inhibitor of Enterovirus Replication That Targets Host Cell Factor Phosphatidylinositol 4-Kinase IIIβ

Antimicrobial Agents and Chemotherapy, 2013-10, Vol.57 (10), p.4971-4981

2013

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Camel Single-domain Antibodies as Modular Building Units in Bispecific and Bivalent Antibody Constructs

The Journal of biological chemistry, 2001-03, Vol.276 (10), p.7346-7350

2001

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Antibody repertoire development in camelids

Developmental and comparative immunology, 2006, Vol.30 (1), p.187-198

2006

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β-Lactamase Inhibitors Derived from Single-Domain Antibody Fragments Elicited in the Camelidae

Antimicrobial Agents and Chemotherapy, 2001-10, Vol.45 (10), p.2807-2812

2001

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Biophysical Properties of Camelid VHH Domains Compared to Those of Human VH3 Domains

Biochemistry (Easton), 2002-03, Vol.41 (11), p.3628-3636

2002

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Identification of a Universal VHH Framework to Graft Non-canonical Antigen-binding Loops of Camel Single-domain Antibodies

Journal of molecular biology, 2005-09, Vol.352 (3), p.597-607

2005

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Identification and Characterization of Novel CFTR Potentiators

Frontiers in pharmacology, 2018-10, Vol.9, p.1221-1221

2018

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A bacterial-two-hybrid selection system for one-step isolation of intracellularly functional Nanobodies

Archives of biochemistry and biophysics, 2012-10, Vol.526 (2), p.114-123

2012

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Identification of GLPG/ABBV-2737, a Novel Class of Corrector, Which Exerts Functional Synergy With Other CFTR Modulators

Frontiers in pharmacology, 2019-05, Vol.10, p.514-514

2019

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High affinity nanobodies against the Trypanosome brucei VSG are potent trypanolytic agents that block endocytosis

PLoS pathogens, 2011-06, Vol.7 (6), p.e1002072

2011

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Efficient tumor targeting by single‐domain antibody fragments of camels

International journal of cancer, 2002-03, Vol.98 (3), p.456-462

2002

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Single Domain Antibodies Derived from Dromedary Lymph Node and Peripheral Blood Lymphocytes Sensing Conformational Variants of Prostate-specific Antigen

The Journal of biological chemistry, 2004-12, Vol.279 (50), p.51965-51972

2004

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CFTR Rescue in Intestinal Organoids with GLPG/ABBV-2737, ABBV/GLPG-2222 and ABBV/GLPG-2451 Triple Therapy

Frontiers in molecular biosciences, 2021-09, Vol.8, p.698358

2021

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Antigen Binding and Solubility Effects upon the Veneering of a Camel VHH in Framework-2 to Mimic a VH

Journal of molecular biology, 2005-07, Vol.350 (1), p.112-125

2005

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Dual Beneficial Effect of Interloop Disulfide Bond for Single Domain Antibody Fragments

The Journal of biological chemistry, 2012-01, Vol.287 (3), p.1970-1979

2012

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Targeting and tracing antigens in live cells with fluorescent nanobodies

Nature methods, 2006-11, Vol.3 (11), p.887-889

2006

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Identifying the molecular target sites for CFTR potentiators GLPG1837 and VX-770

General Strategy to Humanize a Camelid Single-domain Antibody and Identification of a Universal Humanized Nanobody Scaffold

A common mechanism for CFTR potentiators

Preclinical characterization of GLPG0634, a selective inhibitor of JAK1, for the treatment of inflammatory diseases

Disulfide Bond Introduction for General Stabilization of Immunoglobulin Heavy-Chain Variable Domains

Molecular Basis for the Preferential Cleft Recognition by Dromedary Heavy-Chain Antibodies

Discovery of 9‑Cyclopropylethynyl-2-((S)‑1-[1,4]dioxan-2-ylmethoxy)-6,7-dihydropyrimido[6,1‑a]isoquinolin-4-one (GLPG1205), a Unique GPR84 Negative Allosteric Modulator Undergoing Evaluation in a Phase II Clinical Trial

Discovery of N‑(3-Carbamoyl-5,5,7,7-tetramethyl-5,7-dihydro‑4H‑thieno[2,3‑c]pyran-2-yl)‑lH‑pyrazole-5-carboxamide (GLPG1837), a Novel Potentiator Which Can Open Class III Mutant Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Channels to a High Extent

Discovery, Structure–Activity Relationship, and Binding Mode of an Imidazo[1,2‑a]pyridine Series of Autotaxin Inhibitors

A Novel, Broad-Spectrum Inhibitor of Enterovirus Replication That Targets Host Cell Factor Phosphatidylinositol 4-Kinase IIIβ

Camel Single-domain Antibodies as Modular Building Units in Bispecific and Bivalent Antibody Constructs

Antibody repertoire development in camelids

β-Lactamase Inhibitors Derived from Single-Domain Antibody Fragments Elicited in the Camelidae

Biophysical Properties of Camelid VHH Domains Compared to Those of Human VH3 Domains

Identification of a Universal VHH Framework to Graft Non-canonical Antigen-binding Loops of Camel Single-domain Antibodies

Identification and Characterization of Novel CFTR Potentiators

A bacterial-two-hybrid selection system for one-step isolation of intracellularly functional Nanobodies

Identification of GLPG/ABBV-2737, a Novel Class of Corrector, Which Exerts Functional Synergy With Other CFTR Modulators

High affinity nanobodies against the Trypanosome brucei VSG are potent trypanolytic agents that block endocytosis

Efficient tumor targeting by single‐domain antibody fragments of camels

Single Domain Antibodies Derived from Dromedary Lymph Node and Peripheral Blood Lymphocytes Sensing Conformational Variants of Prostate-specific Antigen

CFTR Rescue in Intestinal Organoids with GLPG/ABBV-2737, ABBV/GLPG-2222 and ABBV/GLPG-2451 Triple Therapy

Antigen Binding and Solubility Effects upon the Veneering of a Camel VHH in Framework-2 to Mimic a VH

Dual Beneficial Effect of Interloop Disulfide Bond for Single Domain Antibody Fragments

Targeting and tracing antigens in live cells with fluorescent nanobodies

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