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Discovery of microbial natural products by activation of silent biosynthetic gene clusters

Nature reviews. Microbiology, 2015-08, Vol.13 (8), p.509-523

2015

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Mining microbial genomes for new natural products and biosynthetic pathways

Microbiology (Society for General Microbiology), 2008-06, Vol.154 (Pt 6), p.1555-1569

Challis, Gregory L

2008

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Genome Mining for Novel Natural Product Discovery

Journal of medicinal chemistry, 2008-05, Vol.51 (9), p.2618-2628

Challis, Gregory L

2008

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Mechanism and Catalytic Diversity of Rieske Non-Heme Iron-Dependent Oxygenases

ACS catalysis, 2013-10, Vol.3 (10), p.2362-2370

2013

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Strategies for the Discovery of New Natural Products by Genome Mining

Chembiochem : a European journal of chemical biology, 2009-03, Vol.10 (4), p.625-633

2009

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Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens

Proceedings of the National Academy of Sciences - PNAS, 2011-04, Vol.108 (15), p.6258-6263

2011

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Catalytic Mechanism of Aromatic Nitration by Cytochrome P450 TxtE: Involvement of a Ferric-Peroxynitrite Intermediate

Journal of the American Chemical Society, 2020-09, Vol.142 (37), p.15764-15779

2020

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Widely Distributed Bacterial Pathway for Siderophore Biosynthesis Independent of Nonribosomal Peptide Synthetases

Chembiochem : a European journal of chemical biology, 2005-04, Vol.6 (4), p.601-611

Challis, Gregory L

2005

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New natural product biosynthetic chemistry discovered by genome mining

Natural product reports, 2009-01, Vol.26 (8), p.977-986

2009

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Structures of a non-ribosomal peptide synthetase condensation domain suggest the basis of substrate selectivity

Nature communications, 2021-05, Vol.12 (1), p.2511-2511, Article 2511

2021

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Synergy and Contingency as Driving Forces for the Evolution of Multiple Secondary Metabolite Production by Streptomyces Species

Proceedings of the National Academy of Sciences - PNAS, 2003-11, Vol.100 (Suppl 2), p.14555-14561

2003

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Parallelized gene cluster editing illuminates mechanisms of epoxyketone proteasome inhibitor biosynthesis

Nucleic acids research, 2023-02, Vol.51 (3), p.1488-1499

2023

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Stereochemistry and Mechanism of Undecylprodigiosin Oxidative Carbocyclization to Streptorubin B by the Rieske Oxygenase RedG

Journal of the American Chemical Society, 2015-06, Vol.137 (24), p.7889-7897

2015

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A dual transacylation mechanism for polyketide synthase chain release in enacyloxin antibiotic biosynthesis

Nature chemistry, 2019-10, Vol.11 (10), p.906-912

2019

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Binding of Distinct Substrate Conformations Enables Hydroxylation of Remote Sites in Thaxtomin D by Cytochrome P450 TxtC

Journal of the American Chemical Society, 2019-01, Vol.141 (1), p.216-222

2019

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Genomics‐Driven Discovery of a Novel Glutarimide Antibiotic from Burkholderia gladioli Reveals an Unusual Polyketide Synthase Chain Release Mechanism

Angewandte Chemie International Edition, 2020-12, Vol.59 (51), p.23145-23153

International ed. in English, 2020

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Cytochrome P450–catalyzed L-tryptophan nitration in thaxtomin phytotoxin biosynthesis

Nature chemical biology, 2012-10, Vol.8 (10), p.814-816

2012

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Antimalarial Activity of Natural and Synthetic Prodiginines

Journal of medicinal chemistry, 2011-08, Vol.54 (15), p.5296-5306

2011

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The long-overlooked enzymology of a nonribosomal peptide synthetase-independent pathway for virulence-conferring siderophore biosynthesis

Chemical communications (Cambridge, England), 2009-01 (43), p.6530-6541

2009

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Docking Domain-Mediated Subunit Interactions in Natural Product Megasynth(et)ases

Journal of industrial microbiology & biotechnology, 2021-02, Vol.48 (3-4)

2021

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In Vitro Biosynthetic Studies of Bottromycin Expand the Enzymatic Capabilities of the YcaO Superfamily

Journal of the American Chemical Society, 2017-12, Vol.139 (50), p.18154-18157

2017

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Bovistol B, bovistol D and strossmayerin: Sesquiterpene metabolites from the culture filtrate of the basidiomycete Coprinopsis strossmayeri

PloS one, 2020-04, Vol.15 (4), p.e0229925-e0229925

2020

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Genome mining identifies cepacin as a plant-protective metabolite of the biopesticidal bacterium Burkholderia ambifaria

Nature microbiology, 2019-06, Vol.4 (6), p.996-1005

2019

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The insect pathogen Serratia marcescens Db10 uses a hybrid non-ribosomal peptide synthetase-polyketide synthase to produce the antibiotic althiomycin

PloS one, 2012-09, Vol.7 (9), p.e44673-e44673

2012

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Exploitation of the Streptomyces coelicolor A3(2) genome sequence for discovery of new natural products and biosynthetic pathways

Journal of industrial microbiology & biotechnology, 2014-02, Vol.41 (2), p.219-232

Challis, Gregory L

2014

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Discovery of microbial natural products by activation of silent biosynthetic gene clusters

Mining microbial genomes for new natural products and biosynthetic pathways

Genome Mining for Novel Natural Product Discovery

Mechanism and Catalytic Diversity of Rieske Non-Heme Iron-Dependent Oxygenases

Strategies for the Discovery of New Natural Products by Genome Mining

Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens

Catalytic Mechanism of Aromatic Nitration by Cytochrome P450 TxtE: Involvement of a Ferric-Peroxynitrite Intermediate

Widely Distributed Bacterial Pathway for Siderophore Biosynthesis Independent of Nonribosomal Peptide Synthetases

New natural product biosynthetic chemistry discovered by genome mining

Structures of a non-ribosomal peptide synthetase condensation domain suggest the basis of substrate selectivity

Synergy and Contingency as Driving Forces for the Evolution of Multiple Secondary Metabolite Production by Streptomyces Species

Parallelized gene cluster editing illuminates mechanisms of epoxyketone proteasome inhibitor biosynthesis

Stereochemistry and Mechanism of Undecylprodigiosin Oxidative Carbocyclization to Streptorubin B by the Rieske Oxygenase RedG

A dual transacylation mechanism for polyketide synthase chain release in enacyloxin antibiotic biosynthesis

Binding of Distinct Substrate Conformations Enables Hydroxylation of Remote Sites in Thaxtomin D by Cytochrome P450 TxtC

Genomics‐Driven Discovery of a Novel Glutarimide Antibiotic from Burkholderia gladioli Reveals an Unusual Polyketide Synthase Chain Release Mechanism

Cytochrome P450–catalyzed L-tryptophan nitration in thaxtomin phytotoxin biosynthesis

Antimalarial Activity of Natural and Synthetic Prodiginines

The long-overlooked enzymology of a nonribosomal peptide synthetase-independent pathway for virulence-conferring siderophore biosynthesis

Docking Domain-Mediated Subunit Interactions in Natural Product Megasynth(et)ases

In Vitro Biosynthetic Studies of Bottromycin Expand the Enzymatic Capabilities of the YcaO Superfamily

Bovistol B, bovistol D and strossmayerin: Sesquiterpene metabolites from the culture filtrate of the basidiomycete Coprinopsis strossmayeri

Genome mining identifies cepacin as a plant-protective metabolite of the biopesticidal bacterium Burkholderia ambifaria

The insect pathogen Serratia marcescens Db10 uses a hybrid non-ribosomal peptide synthetase-polyketide synthase to produce the antibiotic althiomycin

Exploitation of the Streptomyces coelicolor A3(2) genome sequence for discovery of new natural products and biosynthetic pathways

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