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Immaturity of human stem-cell-derived cardiomyocytes in culture: fatal flaw or soluble problem?

Stem cells and development, 2015-05, Vol.24 (9), p.1035

2015

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Human iPSC-Derived Cardiomyocytes for Investigation of Disease Mechanisms and Therapeutic Strategies in Inherited Arrhythmia Syndromes: Strengths and Limitations

Cardiovascular drugs and therapy, 2017-06, Vol.31 (3), p.325-344

2017

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Large-Scale Simulation of the Phenotypical Variability Induced by Loss-of-Function Long QT Mutations in Human Induced Pluripotent Stem Cell Cardiomyocytes

International journal of molecular sciences, 2018-11, Vol.19 (11), p.3583

2018

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Cardiomyocytes Derived From Pluripotent Stem Cells Recapitulate Electrophysiological Characteristics of an Overlap Syndrome of Cardiac Sodium Channel Disease

Circulation (New York, N.Y.), 2012-06, Vol.125 (25), p.3079-3091

2012

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Low human dystrophin levels prevent cardiac electrophysiological and structural remodelling in a Duchenne mouse model

Scientific reports, 2021-05, Vol.11 (1), p.9779-9779, Article 9779

2021

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Functional Consequences of the SCN5A -p.Y1977N Mutation within the PY Ubiquitylation Motif: Discrepancy between HEK293 Cells and Transgenic Mice

International journal of molecular sciences, 2019-10, Vol.20 (20), p.5033

2019

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Absence of Functional Nav1.8 Channels in Non-diseased Atrial and Ventricular Cardiomyocytes

Cardiovascular drugs and therapy, 2019-12, Vol.33 (6), p.649-660

2019

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Chronic Mexiletine Administration Increases Sodium Current in Non-Diseased Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Biomedicines, 2024-06, Vol.12 (6), p.1212

2024

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Development of a Hybrid Simulator for Underwater Vehicles With Manipulators

IEEE journal of oceanic engineering, 2020-10, Vol.45 (4), p.1235-1251

2020

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Human iPSC-Derived Cardiomyocytes for Investigation of Disease Mechanisms and Therapeutic Strategies in Inherited Arrhythmia Syndromes: Strengths and Limitations

Cardiovascular drugs and therapy, 2017-06, Vol.31 (3), p.325-344

2017

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PO-660-07 REDUCTION OF MICROTUBULE DETYROSINATION BY PARTHENOLIDE INCREASES SODIUM CURRENT IN CARDIOMYOCYTES FROM PKP2 KNOCKOUT MICE

Heart rhythm, 2022-05, Vol.19 (5), p.S284-S284

2022

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Beneficial effects of chronic mexiletine treatment in a human model of SCN5A overlap syndrome

Europace (London, England), 2023-06, Vol.25 (6)

2023

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Decreasing microtubule detyrosination modulates Nav1.5 subcellular distribution and restores sodium current in mdx cardiomyocytes

Cardiovascular research, 2024-05, Vol.120 (7), p.723-734

2024

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Isogenic human pluripotent stem cell pairs reveal the role of a KCNH2 mutation in long-QT syndrome

The EMBO journal, 2013-12, Vol.32 (24), p.3161-3175

2013

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Design and realization of the CUFF - clenching upper-limb force feedback wearable device for distributed mechano-tactile stimulation of normal and tangential skin forces

2015 IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS), 2015, p.1186-1193

2015

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Inhibition of minor intron splicing reduces Na+ and Ca2+ channel expression and function in cardiomyocytes

Journal of cell science, 2022-01, Vol.135 (1)

2022

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PO-02-042 ROLE OF WT1 IN BRUGADA SYNDROME PATHOPHYSIOLOGY

Heart rhythm, 2024-05, Vol.21 (5), p.S323-S323

2024

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Chronically elevated branched chain amino acid levels are pro-arrhythmic

Cardiovascular research, 2022-06, Vol.118 (7), p.1742-1757

2022

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Targeting the Microtubule EB1-CLASP2 Complex Modulates Na V 1.5 at Intercalated Discs

Circulation research, 2021-07, Vol.129 (3), p.349-365

2021

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NKX2-5 regulates human cardiomyogenesis via a HEY2 dependent transcriptional network

Nature communications, 2018-04, Vol.9 (1), p.1373-13, Article 1373

2018

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Pluripotent stem cell models of cardiac disease and their implication for drug discovery and development

Trends in molecular medicine, 2011-09, Vol.17 (9), p.475-484

2011

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Anti-arrhythmic potential of the late sodium current inhibitor GS-458967 in murine Scn5a-1798insD+/- and human SCN5A-1795insD+/- iPSC-derived cardiomyocytes

Cardiovascular research, 2017-06, Vol.113 (7), p.829-838

2017

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Desmosomal protein degradation as an underlying cause of arrhythmogenic cardiomyopathy

Science translational medicine, 2023-03, Vol.15 (688), p.eadd4248

2023

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Gene- and variant-specific efficacy of serum/glucocorticoid-regulated kinase 1 inhibition in long QT syndrome types 1 and 2

Europace (London, England), 2023-05, Vol.25 (5)

2023

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Differential Sodium Current Remodelling Identifies Distinct Cellular Proarrhythmic Mechanisms in Paroxysmal vs Persistent Atrial Fibrillation

Canadian journal of cardiology, 2023-03, Vol.39 (3), p.277-288

2023

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Immaturity of human stem-cell-derived cardiomyocytes in culture: fatal flaw or soluble problem?

Human iPSC-Derived Cardiomyocytes for Investigation of Disease Mechanisms and Therapeutic Strategies in Inherited Arrhythmia Syndromes: Strengths and Limitations

Large-Scale Simulation of the Phenotypical Variability Induced by Loss-of-Function Long QT Mutations in Human Induced Pluripotent Stem Cell Cardiomyocytes

Cardiomyocytes Derived From Pluripotent Stem Cells Recapitulate Electrophysiological Characteristics of an Overlap Syndrome of Cardiac Sodium Channel Disease

Low human dystrophin levels prevent cardiac electrophysiological and structural remodelling in a Duchenne mouse model

Functional Consequences of the SCN5A -p.Y1977N Mutation within the PY Ubiquitylation Motif: Discrepancy between HEK293 Cells and Transgenic Mice

Absence of Functional Nav1.8 Channels in Non-diseased Atrial and Ventricular Cardiomyocytes

Chronic Mexiletine Administration Increases Sodium Current in Non-Diseased Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Development of a Hybrid Simulator for Underwater Vehicles With Manipulators

Human iPSC-Derived Cardiomyocytes for Investigation of Disease Mechanisms and Therapeutic Strategies in Inherited Arrhythmia Syndromes: Strengths and Limitations

PO-660-07 REDUCTION OF MICROTUBULE DETYROSINATION BY PARTHENOLIDE INCREASES SODIUM CURRENT IN CARDIOMYOCYTES FROM PKP2 KNOCKOUT MICE

Beneficial effects of chronic mexiletine treatment in a human model of SCN5A overlap syndrome

Decreasing microtubule detyrosination modulates Nav1.5 subcellular distribution and restores sodium current in mdx cardiomyocytes

Isogenic human pluripotent stem cell pairs reveal the role of a KCNH2 mutation in long-QT syndrome

Design and realization of the CUFF - clenching upper-limb force feedback wearable device for distributed mechano-tactile stimulation of normal and tangential skin forces

Inhibition of minor intron splicing reduces Na+ and Ca2+ channel expression and function in cardiomyocytes

PO-02-042 ROLE OF WT1 IN BRUGADA SYNDROME PATHOPHYSIOLOGY

Chronically elevated branched chain amino acid levels are pro-arrhythmic

Targeting the Microtubule EB1-CLASP2 Complex Modulates Na V 1.5 at Intercalated Discs

NKX2-5 regulates human cardiomyogenesis via a HEY2 dependent transcriptional network

Pluripotent stem cell models of cardiac disease and their implication for drug discovery and development

Anti-arrhythmic potential of the late sodium current inhibitor GS-458967 in murine Scn5a-1798insD+/- and human SCN5A-1795insD+/- iPSC-derived cardiomyocytes

Desmosomal protein degradation as an underlying cause of arrhythmogenic cardiomyopathy

Gene- and variant-specific efficacy of serum/glucocorticoid-regulated kinase 1 inhibition in long QT syndrome types 1 and 2

Differential Sodium Current Remodelling Identifies Distinct Cellular Proarrhythmic Mechanisms in Paroxysmal vs Persistent Atrial Fibrillation

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