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Amidino-Rocaglates: A Potent Class of eIF4A Inhibitors

Cell chemical biology, 2019-11, Vol.26 (11), p.1586-1593.e3

2019

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Heat Shock Factor 1-dependent extracellular matrix remodeling mediates the transition from chronic intestinal inflammation to colon cancer

Nature communications, 2020-12, Vol.11 (1), p.6245-6245, Article 6245

2020

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BRCA mutational status shapes the stromal microenvironment of pancreatic cancer linking clusterin expression in cancer associated fibroblasts with HSF1 signaling

Nature communications, 2022-10, Vol.13 (1), p.6513-6513, Article 6513

2022

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eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma

Nature communications, 2019-11, Vol.10 (1), p.5151-16, Article 5151

2019

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An oxindole efflux inhibitor potentiates azoles and impairs virulence in the fungal pathogen Candida auris

Nature communications, 2020-12, Vol.11 (1), p.6429-17, Article 6429

2020

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The MYCN 5′ UTR as a therapeutic target in neuroblastoma

Cell reports (Cambridge), 2024-05, Vol.43 (5), p.114134-114134, Article 114134

2024

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Translation Inhibition by Rocaglates Activates a Species-Specific Cell Death Program in the Emerging Fungal Pathogen Candida auris

mBio, 2020-03, Vol.11 (2)

2020

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Rocaglates Induce Gain-of-Function Alterations to eIF4A and eIF4F

Cell reports (Cambridge), 2020-02, Vol.30 (8), p.2481-2488.e5

2020

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Identification of structurally re-engineered rocaglates as inhibitors against hepatitis E virus replication

Antiviral research, 2022-08, Vol.204, p.105359-105359, Article 105359

2022

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Targeting translation initiation by synthetic rocaglates for treating MYC-driven lymphomas

Leukemia, 2020-01, Vol.34 (1), p.138-150

2020

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Rocaglates as dual-targeting agents for experimental cerebral malaria

Proceedings of the National Academy of Sciences - PNAS, 2018-03, Vol.115 (10), p.E2366-E2375

2018

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Inhibiting the oncogenic translation program is an effective therapeutic strategy in multiple myeloma

Science translational medicine, 2017-05, Vol.9 (389)

2017

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Condensation tendency and planar isotropic actin gradient induce radial alignment in confined monolayers

eLife, 2021-09, Vol.10

2021

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A chemical screen identifies structurally diverse metal chelators with activity against the fungal pathogen Candida albicans

Microbiology spectrum, 2024-04, Vol.12 (4), p.e0409523-e0409523

2024

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Asymmetric Dearomatization/Cyclization Enables Access to Polycyclic Chemotypes

European journal of organic chemistry, 2016-10, Vol.2016 (28), p.4800-4804

2016

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Oxo-aglaiastatin-Mediated Inhibition of Translation Initiation

Scientific reports, 2019-02, Vol.9 (1), p.1265-1265, Article 1265

2019

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Janus nanoparticles: reaction dynamics and NOESY characterization

Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology, 2009-11, Vol.11 (8), p.1895-1903

2009

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A Novel Class of Small Molecule Compounds that Inhibit Hepatitis C Virus Infection by Targeting the Prohibitin-CRaf Pathway

EBioMedicine, 2015-11, Vol.2 (11), p.1600-1606

2015

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Channeling macrophage polarization by rocaglates increases macrophage resistance to Mycobacterium tuberculosis

iScience, 2021-08, Vol.24 (8), p.102845, Article 102845

2021

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Neighborhood cohesion and psychological distress across race and sexual orientation

SSM - population health, 2022-06, Vol.18, p.101134-101134, Article 101134

2022

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Defining and navigating macrocycle chemical space

Chemical science (Cambridge), 2021-04, Vol.12 (12), p.439-4328

2021

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Design and Synthesis of Fungal-Selective Resorcylate Aminopyrazole Hsp90 Inhibitors

Journal of medicinal chemistry, 2020-03, Vol.63 (5), p.2139-2180

2020

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Discovery of new antimalarial chemotypes through chemical methodology and library development

Proceedings of the National Academy of Sciences - PNAS, 2011-04, Vol.108 (17), p.6775-6780

2011

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Divergent, C–C Bond Forming Macrocyclizations Using Modular Sulfonylhydrazone and Derived Substrates

Journal of organic chemistry, 2021-12, Vol.86 (23), p.16485-16510

2021

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Socioeconomic Disadvantage and Distance to Pediatric Critical Care

Pediatric critical care medicine, 2021-12, Vol.22 (12), p.1033

2021

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Amidino-Rocaglates: A Potent Class of eIF4A Inhibitors

Heat Shock Factor 1-dependent extracellular matrix remodeling mediates the transition from chronic intestinal inflammation to colon cancer

BRCA mutational status shapes the stromal microenvironment of pancreatic cancer linking clusterin expression in cancer associated fibroblasts with HSF1 signaling

eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma

An oxindole efflux inhibitor potentiates azoles and impairs virulence in the fungal pathogen Candida auris

The MYCN 5′ UTR as a therapeutic target in neuroblastoma

Translation Inhibition by Rocaglates Activates a Species-Specific Cell Death Program in the Emerging Fungal Pathogen Candida auris

Rocaglates Induce Gain-of-Function Alterations to eIF4A and eIF4F

Identification of structurally re-engineered rocaglates as inhibitors against hepatitis E virus replication

Targeting translation initiation by synthetic rocaglates for treating MYC-driven lymphomas

Rocaglates as dual-targeting agents for experimental cerebral malaria

Inhibiting the oncogenic translation program is an effective therapeutic strategy in multiple myeloma

Condensation tendency and planar isotropic actin gradient induce radial alignment in confined monolayers

A chemical screen identifies structurally diverse metal chelators with activity against the fungal pathogen Candida albicans

Asymmetric Dearomatization/Cyclization Enables Access to Polycyclic Chemotypes

Oxo-aglaiastatin-Mediated Inhibition of Translation Initiation

Janus nanoparticles: reaction dynamics and NOESY characterization

A Novel Class of Small Molecule Compounds that Inhibit Hepatitis C Virus Infection by Targeting the Prohibitin-CRaf Pathway

Channeling macrophage polarization by rocaglates increases macrophage resistance to Mycobacterium tuberculosis

Neighborhood cohesion and psychological distress across race and sexual orientation

Defining and navigating macrocycle chemical space

Design and Synthesis of Fungal-Selective Resorcylate Aminopyrazole Hsp90 Inhibitors

Discovery of new antimalarial chemotypes through chemical methodology and library development

Divergent, C–C Bond Forming Macrocyclizations Using Modular Sulfonylhydrazone and Derived Substrates

Socioeconomic Disadvantage and Distance to Pediatric Critical Care

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