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Advances in therapeutic peptides targeting G protein-coupled receptors

Nature reviews. Drug discovery, 2020-06, Vol.19 (6), p.389-413

2020

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Crystal structure of the GLP-1 receptor bound to a peptide agonist

Nature (London), 2017-06, Vol.546 (7657), p.254-258

2017

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Extra-helical binding site of a glucagon receptor antagonist

Nature (London), 2016-05, Vol.533 (7602), p.274-277

2016

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Acetylcholine prioritises direct synaptic inputs from entorhinal cortex to CA1 by differential modulation of feedforward inhibitory circuits

Nature communications, 2021-09, Vol.12 (1), p.5475-5475, Article 5475

2021

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Author Correction: Acetylcholine prioritises direct synaptic inputs from entorhinal cortex to CA1 by differential modulation of feedforward inhibitory circuits

Nature communications, 2021-12, Vol.12 (1), p.7265-7265, Article 7265

2021

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Glucagon-Like Peptide-1 and Its Class B G Protein-Coupled Receptors: A Long March to Therapeutic Successes

Pharmacological reviews, 2016-10, Vol.68 (4), p.954-1013

2016

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Differential signaling by splice variants of the human free fatty acid receptor GPR120

Molecular pharmacology, 2012-05, Vol.81 (5), p.631-642

2012

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Expanding the apelin receptor pharmacological toolbox using novel fluorescent ligands

Frontiers in endocrinology (Lausanne), 2023-03, Vol.14, p.1139121-1139121

2023

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Identification, Optimization, and Pharmacology of Acylurea GHS-R1a Inverse Agonists

Journal of medicinal chemistry, 2014-07, Vol.57 (14), p.6128-6140

2014

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Structures of G protein-coupled receptors reveal new opportunities for drug discovery

Drug discovery today, 2015-11, Vol.20 (11), p.1355-1364

2015

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Short Chain Fatty Acids Enhance Expression and Activity of the Umami Taste Receptor in Enteroendocrine Cells via a Gαi/o Pathway

Frontiers in nutrition (Lausanne), 2020-10, Vol.7, p.568991-568991

2020

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Regional characterisation of TRPV1 and TRPA1 signalling in the mouse colon mucosa

European journal of pharmacology, 2023-09, Vol.954, p.175897-175897, Article 175897

2023

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Cholinergic muscarinic M 1 and M 4 receptors as therapeutic targets for cognitive, behavioural, and psychological symptoms in psychiatric and neurological disorders

Drug discovery today, 2019-12, Vol.24 (12), p.2307

2019

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An integrated approach to fragment-based lead generation: philosophy, strategy and case studies from AstraZeneca's drug discovery programmes

Current topics in medicinal chemistry, 2007-08, Vol.7 (16), p.1600

2007

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Roles of GPR41 and GPR43 in leptin secretory responses of murine adipocytes to short chain fatty acids

FEBS letters, 2010-06, Vol.584 (11), p.2381-2386

2010

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A novel somatostatin receptor ligand for human ACTH - and GH -secreting pituitary adenomas

European journal of endocrinology, 2024-01, Vol.190 (1), p.K8

2024

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In vitro metabolism of synthetic Elabela/Toddler (ELA-32) peptide in human plasma and kidney homogenates analyzed with mass spectrometry and validation of endogenous peptide quantification in tissues by ELISA

Peptides (New York, N.Y. : 1980), 2021-11, Vol.145, p.170642-170642, Article 170642

2021

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Identification of a novel allosteric GLP-1R antagonist HTL26119 using structure-based drug design

Bioorganic & medicinal chemistry letters, 2019-10, Vol.29 (20), p.126611-126611, Article 126611

2019

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Indazole-6-phenylcyclopropylcarboxylic Acids as Selective GPR120 Agonists with in Vivo Efficacy

Journal of medicinal chemistry, 2017-04, Vol.60 (7), p.3187-3197

2017

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A phase 1b/2a multicenter study of the safety and preliminary pharmacodynamic effects of selective muscarinic M 1 receptor agonist HTL0018318 in patients with mild-to-moderate Alzheimer's disease

Alzheimer's & dementia : translational research & clinical interventions, 2022, Vol.8 (1), p.e12273

2022

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Corrigendum: Crystal structure of the GLP-1 receptor bound to a peptide agonist

Nature (London), 2017-08, Vol.548 (7665), p.122-122

2017

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Drug discovery opportunities and challenges at g protein coupled receptors for long chain free Fatty acids

Frontiers in endocrinology (Lausanne), 2012, Vol.2, p.112-112

2012

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Gastrointestinal and metabolic function in the MPTP-treated macaque model of Parkinson's disease

Heliyon, 2020-12, Vol.6 (12), p.e05771-e05771, Article e05771

2020

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Cholinergic muscarinic M1 and M4 receptors as therapeutic targets for cognitive, behavioural, and psychological symptoms in psychiatric and neurological disorders

Drug discovery today, 2019-12, Vol.24 (12), p.2307-2314

2019

Volltextzugriff (PDF)

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Advances in therapeutic peptides targeting G protein-coupled receptors

Crystal structure of the GLP-1 receptor bound to a peptide agonist

Extra-helical binding site of a glucagon receptor antagonist

Acetylcholine prioritises direct synaptic inputs from entorhinal cortex to CA1 by differential modulation of feedforward inhibitory circuits

Author Correction: Acetylcholine prioritises direct synaptic inputs from entorhinal cortex to CA1 by differential modulation of feedforward inhibitory circuits

Glucagon-Like Peptide-1 and Its Class B G Protein-Coupled Receptors: A Long March to Therapeutic Successes

Differential signaling by splice variants of the human free fatty acid receptor GPR120

Expanding the apelin receptor pharmacological toolbox using novel fluorescent ligands

Identification, Optimization, and Pharmacology of Acylurea GHS-R1a Inverse Agonists

Structures of G protein-coupled receptors reveal new opportunities for drug discovery

Short Chain Fatty Acids Enhance Expression and Activity of the Umami Taste Receptor in Enteroendocrine Cells via a Gαi/o Pathway

Regional characterisation of TRPV1 and TRPA1 signalling in the mouse colon mucosa

Cholinergic muscarinic M 1 and M 4 receptors as therapeutic targets for cognitive, behavioural, and psychological symptoms in psychiatric and neurological disorders

An integrated approach to fragment-based lead generation: philosophy, strategy and case studies from AstraZeneca's drug discovery programmes

Roles of GPR41 and GPR43 in leptin secretory responses of murine adipocytes to short chain fatty acids

A novel somatostatin receptor ligand for human ACTH - and GH -secreting pituitary adenomas

In vitro metabolism of synthetic Elabela/Toddler (ELA-32) peptide in human plasma and kidney homogenates analyzed with mass spectrometry and validation of endogenous peptide quantification in tissues by ELISA

Identification of a novel allosteric GLP-1R antagonist HTL26119 using structure-based drug design

Indazole-6-phenylcyclopropylcarboxylic Acids as Selective GPR120 Agonists with in Vivo Efficacy

A phase 1b/2a multicenter study of the safety and preliminary pharmacodynamic effects of selective muscarinic M 1 receptor agonist HTL0018318 in patients with mild-to-moderate Alzheimer's disease

Corrigendum: Crystal structure of the GLP-1 receptor bound to a peptide agonist

Drug discovery opportunities and challenges at g protein coupled receptors for long chain free Fatty acids

Gastrointestinal and metabolic function in the MPTP-treated macaque model of Parkinson's disease

Cholinergic muscarinic M1 and M4 receptors as therapeutic targets for cognitive, behavioural, and psychological symptoms in psychiatric and neurological disorders

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