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In Vitro Blood–Brain Barrier Models—An Overview of Established Models and New Microfluidic Approaches

Journal of pharmaceutical sciences, 2015-09, Vol.104 (9), p.2727-2746

2015

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Routes for Drug Translocation Across the Blood-Brain Barrier: Exploiting Peptides as Delivery Vectors

Journal of pharmaceutical sciences, 2017-09, Vol.106 (9), p.2326-2334

2017

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Stimulation-induced increases in cerebral blood flow and local capillary vasoconstriction depend on conducted vascular responses

Proceedings of the National Academy of Sciences - PNAS, 2018-06, Vol.115 (25), p.E5796-E5804

2018

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Precapillary sphincters and pericytes at first-order capillaries as key regulators for brain capillary perfusion

Proceedings of the National Academy of Sciences - PNAS, 2021-06, Vol.118 (26)

2021

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Effects of oxygen-glucose deprivation (OGD) on barrier properties and mRNA transcript levels of selected marker proteins in brain endothelial cells/astrocyte co-cultures

PloS one, 2019-08, Vol.14 (8), p.e0221103-e0221103

2019

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Hypoxia increases expression of selected blood-brain barrier transporters GLUT-1, P-gp, SLC7A5 and TFRC, while maintaining barrier integrity, in brain capillary endothelial monolayers

Fluids and barriers of the CNS, 2022-01, Vol.19 (1), p.1-1, Article 1

2022

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Application of a new MDCKII-MDR1 cell model to measure the extent of drug distribution in vitro at equilibrium for prediction of in vivo unbound brain-to-plasma drug distribution

Fluids and barriers of the CNS, 2024-01, Vol.21 (1), p.11-11, Article 11

2024

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Transendothelial Electrical Resistance Measurement across the Blood–Brain Barrier: A Critical Review of Methods

Micromachines (Basel), 2021-06, Vol.12 (6), p.685

2021

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Generation of an iPSC-line (BIONi010C-48) with restored P-glycoprotein functionality following transfection with the human MDR1 gene in the AAVS1 locus

Stem cell research, 2024-04, Vol.76, p.103348-103348, Article 103348

2024

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Characterization of the IPEC-J2 MDR1 (iP-gp) cell line as a tool for identification of P-gp substrates

European journal of pharmaceutical sciences, 2018-01, Vol.112, p.112-121

2018

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Screening novel CNS drug candidates for P-glycoprotein interactions using the cell line iP-gp: In vitro efflux ratios from iP-gp and MDCK-MDR1 monolayers compared to brain distribution data from mice

European journal of pharmaceutics and biopharmaceutics, 2021-12, Vol.169, p.211-219

2021

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The putative proton-coupled organic cation antiporter is involved in uptake of triptans into human brain capillary endothelial cells

Fluids and barriers of the CNS, 2024-05, Vol.21 (1), p.39-39

2024

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The solute carrier SLC7A1 may act as a protein transporter at the blood-brain barrier

European journal of cell biology, 2024-06, Vol.103 (2), p.151406-151406, Article 151406

2024

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Subcellular trafficking and transcytosis efficacy of different receptor types for therapeutic antibody delivery at the blood‒brain barrier

Fluids and barriers of the CNS, 2023-11, Vol.20 (1), p.1-82, Article 82

2023

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Apicobasal transferrin receptor localization and trafficking in brain capillary endothelial cells

Fluids and barriers of the CNS, 2023-01, Vol.20 (1), p.2-2, Article 2

2023

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In vitro blood–brain barrier permeability predictions for GABAA receptor modulating piperine analogs

European journal of pharmaceutics and biopharmaceutics, 2016-06, Vol.103, p.118-126

2016

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An Electrically Tight In Vitro Blood–Brain Barrier Model Displays Net Brain-to-Blood Efflux of Substrates for the ABC Transporters, P-gp, Bcrp and Mrp-1

The AAPS journal, 2014-09, Vol.16 (5), p.1046-1055

2014

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Correction to: Apicobasal transferrin receptor localization and trafficking in brain capillary endothelial cells

Fluids and barriers of the CNS, 2023-06, Vol.20 (1), p.48-48, Article 48

2023

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Characterization of an iPSC-based barrier model for blood-brain barrier investigations using the SBAD0201 stem cell line

Fluids and barriers of the CNS, 2023-12, Vol.20 (1), p.96-96, Article 96

2023

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Comparison of drug transporter gene expression and functionality in Caco-2 cells from 10 different laboratories

European journal of pharmaceutical sciences, 2008-12, Vol.35 (5), p.383-396

2008

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Glutamate Efflux at the Blood–Brain Barrier: Cellular Mechanisms and Potential Clinical Relevance

Archives of medical research, 2014-11, Vol.45 (8), p.639-645

2014

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Bidirectional apical–basal traffic of the cation-independent mannose-6-phosphate receptor in brain endothelial cells

Journal of cerebral blood flow and metabolism, 2017-07, Vol.37 (7), p.2598-2613

2017

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A Critical View on In Vitro Analysis of P-glycoprotein (P-gp) Transport Kinetics

Journal of pharmaceutical sciences, 2017-09, Vol.106 (9), p.2257-2264

2017

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Characterization of the L-glutamate clearance pathways across the blood–brain barrier and the effect of astrocytes in an in vitro blood–brain barrier model

Journal of cerebral blood flow and metabolism, 2017-12, Vol.37 (12), p.3744-3758

2017

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IPEC-J2 rMdr1a, a New Cell Line with Functional Expression of Rat P-glycoprotein Encoded by Rat Mdr1a for Drug Screening Purposes

Pharmaceutics, 2020-07, Vol.12 (7), p.673

2020

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In Vitro Blood–Brain Barrier Models—An Overview of Established Models and New Microfluidic Approaches

Routes for Drug Translocation Across the Blood-Brain Barrier: Exploiting Peptides as Delivery Vectors

Stimulation-induced increases in cerebral blood flow and local capillary vasoconstriction depend on conducted vascular responses

Precapillary sphincters and pericytes at first-order capillaries as key regulators for brain capillary perfusion

Effects of oxygen-glucose deprivation (OGD) on barrier properties and mRNA transcript levels of selected marker proteins in brain endothelial cells/astrocyte co-cultures

Hypoxia increases expression of selected blood-brain barrier transporters GLUT-1, P-gp, SLC7A5 and TFRC, while maintaining barrier integrity, in brain capillary endothelial monolayers

Application of a new MDCKII-MDR1 cell model to measure the extent of drug distribution in vitro at equilibrium for prediction of in vivo unbound brain-to-plasma drug distribution

Transendothelial Electrical Resistance Measurement across the Blood–Brain Barrier: A Critical Review of Methods

Generation of an iPSC-line (BIONi010C-48) with restored P-glycoprotein functionality following transfection with the human MDR1 gene in the AAVS1 locus

Characterization of the IPEC-J2 MDR1 (iP-gp) cell line as a tool for identification of P-gp substrates

Screening novel CNS drug candidates for P-glycoprotein interactions using the cell line iP-gp: In vitro efflux ratios from iP-gp and MDCK-MDR1 monolayers compared to brain distribution data from mice

The putative proton-coupled organic cation antiporter is involved in uptake of triptans into human brain capillary endothelial cells

The solute carrier SLC7A1 may act as a protein transporter at the blood-brain barrier

Subcellular trafficking and transcytosis efficacy of different receptor types for therapeutic antibody delivery at the blood‒brain barrier

Apicobasal transferrin receptor localization and trafficking in brain capillary endothelial cells

In vitro blood–brain barrier permeability predictions for GABAA receptor modulating piperine analogs

An Electrically Tight In Vitro Blood–Brain Barrier Model Displays Net Brain-to-Blood Efflux of Substrates for the ABC Transporters, P-gp, Bcrp and Mrp-1

Correction to: Apicobasal transferrin receptor localization and trafficking in brain capillary endothelial cells

Characterization of an iPSC-based barrier model for blood-brain barrier investigations using the SBAD0201 stem cell line

Comparison of drug transporter gene expression and functionality in Caco-2 cells from 10 different laboratories

Glutamate Efflux at the Blood–Brain Barrier: Cellular Mechanisms and Potential Clinical Relevance

Bidirectional apical–basal traffic of the cation-independent mannose-6-phosphate receptor in brain endothelial cells

A Critical View on In Vitro Analysis of P-glycoprotein (P-gp) Transport Kinetics

Characterization of the L-glutamate clearance pathways across the blood–brain barrier and the effect of astrocytes in an in vitro blood–brain barrier model

IPEC-J2 rMdr1a, a New Cell Line with Functional Expression of Rat P-glycoprotein Encoded by Rat Mdr1a for Drug Screening Purposes

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