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Methodological issues in microdialysis sampling for pharmacokinetic studies

Advanced drug delivery reviews, 2000-12, Vol.45 (2), p.125-148

2000

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Assessment of active transport of HIV protease inhibitors in various cell lines and the in vitro blood-brain barrier

AIDS (London), 2001-03, Vol.15 (4), p.483-491

2001

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PK/PD Modelling and Beyond: Impact on Drug Development

Pharmaceutical research, 2008-12, Vol.25 (12), p.2720-2722

Breimer, Douwe D.

2008

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Specificity of doxorubicin versus rhodamine-123 in assessing P-glycoprotein functionality in the LLC-PK1, LLC-PK1:MDR1 and Caco-2 cell lines

European journal of pharmaceutical sciences, 2000-09, Vol.11 (3), p.207-214

2000

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BBB transport and P-glycoprotein functionality using MDR1A (-/-) and wild-type mice. Total brain versus microdialysis concentration profiles of rhodamine-123

Pharmaceutical research, 1998-11, Vol.15 (11), p.1657-1665

1998

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Brain penetration and in vivo recovery of NMDA receptor antagonists amantadine and memantine : A quantitative microdialysis study

Pharmaceutical research, 1999-05, Vol.16 (5), p.637-642

1999

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Mobility rethought

Nature (London), 2011-02, Vol.470 (7335), p.565-565

2011

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Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier

The Journal of clinical investigation, 2000-02, Vol.105 (3), p.279-285

2000

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The influence of cytokines on the integrity of the blood-brain barrier in vitro

Journal of neuroimmunology, 1996, Vol.64 (1), p.37-43

1996

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Pharmacology in The Netherlands: past, present and future

Trends in pharmacological sciences (Regular ed.), 2008-04, Vol.29 (4), p.167-169

2008

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Grapefruit juice and cimetidine inhibit stereoselective metabolism of nitrendipine in humans

Clinical pharmacology and therapeutics, 1991-10, Vol.50 (4), p.394-403

1991

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Effects of the Mucoadhesive Polymer Polycarbophil on the Intestinal Absorption of a Peptide Drug in the Rat

Journal of pharmacy and pharmacology, 1992-05, Vol.44 (5), p.402-407

1992

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Pharmacological investigations on lipopolysaccharide-induced permeability changes in the blood–brain barrier in vitro

Microvascular research, 2003, Vol.65 (1), p.24-31

2003

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Microdialysis for pharmacokinetic analysis of drug transport to the brain

Advanced drug delivery reviews, 1999-04, Vol.36 (2), p.211-227

1999

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Glucocorticoid and type I interferon interactions at the blood-brain barrier: relevance for drug therapies for multiple sclerosis

Neuroreport, 2001-07, Vol.12 (10), p.2189-2193

2001

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Pharmacokinetic-pharmacodynamic modeling of the central nervous system effects of midazolam and its main metabolite α-hydroxymidazolam in healthy volunteers

Clinical pharmacology and therapeutics, 1992-06, Vol.51 (6), p.715-728

1992

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Future training needs in the pharmaceutical sciences: Academia – Industry

European journal of pharmaceutical sciences, 2001-02, Vol.12 (4), p.347-352

Breimer, Douwe D.

2001

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Methodological considerations of intracerebral microdialysis in pharmacokinetic studies on drug transport across the blood–brain barrier

Brain Research Reviews, 1997-09, Vol.25 (1), p.27-49

1997

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Active efflux of the 5-HT1A receptor agonist flesinoxan via P-glycoprotein at the blood-brain barrier

European journal of pharmaceutical sciences, 2001-08, Vol.14 (1), p.81-86

2001

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P-glycoprotein inhibition leads to enhanced disruptive effects by anti-microtubule cytostatics at the in vitro blood-brain barrier

Pharmaceutical research, 2001-05, Vol.18 (5), p.587-592

2001

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In vitro and in vivo transport of zidovudine (AZT) across the blood-brain barrier and the effect of transport inhibitors

Pharmaceutical research, 1994-02, Vol.11 (2), p.324-330

1994

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Hora est: On dissertations. [Catalogue of an exhibition in Leiden University Library, December, 8, 2005 - February 4, 2006]

2005

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A comparison of the sensitivities of adaptive tracking, eye movement analysis, and visual analog lines to the effects of incremental doses of temazepam in healthy volunteers

Clinical pharmacology and therapeutics, 1991-08, Vol.50 (2), p.172-180

1991

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The blood-brain barrier in neuroinflammatory diseases

Pharmacological reviews, 1997-06, Vol.49 (2), p.143

1997

Volltextzugriff (PDF)

Glucocorticoid and type 1 interferon interactions at the blood–brain barrier: relevance for drug therapies for multiple sclerosis

Neuroreport, 2001-07, Vol.12 (10), p.2189-2193

2001

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Methodological issues in microdialysis sampling for pharmacokinetic studies

Assessment of active transport of HIV protease inhibitors in various cell lines and the in vitro blood-brain barrier

PK/PD Modelling and Beyond: Impact on Drug Development

Specificity of doxorubicin versus rhodamine-123 in assessing P-glycoprotein functionality in the LLC-PK1, LLC-PK1:MDR1 and Caco-2 cell lines

BBB transport and P-glycoprotein functionality using MDR1A (-/-) and wild-type mice. Total brain versus microdialysis concentration profiles of rhodamine-123

Brain penetration and in vivo recovery of NMDA receptor antagonists amantadine and memantine : A quantitative microdialysis study

Mobility rethought

Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier

The influence of cytokines on the integrity of the blood-brain barrier in vitro

Pharmacology in The Netherlands: past, present and future

Grapefruit juice and cimetidine inhibit stereoselective metabolism of nitrendipine in humans

Effects of the Mucoadhesive Polymer Polycarbophil on the Intestinal Absorption of a Peptide Drug in the Rat

Pharmacological investigations on lipopolysaccharide-induced permeability changes in the blood–brain barrier in vitro

Microdialysis for pharmacokinetic analysis of drug transport to the brain

Glucocorticoid and type I interferon interactions at the blood-brain barrier: relevance for drug therapies for multiple sclerosis

Pharmacokinetic-pharmacodynamic modeling of the central nervous system effects of midazolam and its main metabolite α-hydroxymidazolam in healthy volunteers

Future training needs in the pharmaceutical sciences: Academia – Industry

Methodological considerations of intracerebral microdialysis in pharmacokinetic studies on drug transport across the blood–brain barrier

Active efflux of the 5-HT1A receptor agonist flesinoxan via P-glycoprotein at the blood-brain barrier

P-glycoprotein inhibition leads to enhanced disruptive effects by anti-microtubule cytostatics at the in vitro blood-brain barrier

In vitro and in vivo transport of zidovudine (AZT) across the blood-brain barrier and the effect of transport inhibitors

Hora est: On dissertations. [Catalogue of an exhibition in Leiden University Library, December, 8, 2005 - February 4, 2006]

A comparison of the sensitivities of adaptive tracking, eye movement analysis, and visual analog lines to the effects of incremental doses of temazepam in healthy volunteers

The blood-brain barrier in neuroinflammatory diseases

Glucocorticoid and type 1 interferon interactions at the blood–brain barrier: relevance for drug therapies for multiple sclerosis

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