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Complementary Actions of Inhibitors of Angiopoietin-2 and VEGF on Tumor Angiogenesis and Growth

Cancer research (Chicago, Ill.), 2010-03, Vol.70 (6), p.2213-2223

2010

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Contrasting Actions of Selective Inhibitors of Angiopoietin-1 and Angiopoietin-2 on the Normalization of Tumor Blood Vessels

The American journal of pathology, 2009-11, Vol.175 (5), p.2159-2170

2009

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Evolution of a Highly Selective and Potent 2-(Pyridin-2-yl)-1,3,5-triazine Tie-2 Kinase Inhibitor

Journal of medicinal chemistry, 2007-02, Vol.50 (4), p.611-626

2007

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Keratinocyte growth factor protects mice from chemotherapy and radiation-induced gastrointestinal injury and mortality

Cancer research (Chicago, Ill.), 1998-03, Vol.58 (5), p.933-939

1998

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The Antiproliferative Activity of c-myb and c-myc Antisense Oligonucleotides in Smooth Muscle Cells is Caused by a Nonantisense Mechanism

Proceedings of the National Academy of Sciences - PNAS, 1995-04, Vol.92 (9), p.4051-4055

1995

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Stimulatory Effects of B7-Related Protein-1 on Cellular and Humoral Immune Responses in Mice

The Journal of immunology (1950), 2001-05, Vol.166 (9), p.5578-5584

2001

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AMG 706, an oral, multikinase inhibitor that selectively targets vascular endothelial growth factor, platelet-derived growth factor, and kit receptors, potently inhibits angiogenesis and induces regression in tumor xenografts

Cancer research (Chicago, Ill.), 2006-09, Vol.66 (17), p.8715-8721

2006

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AMG 386, a selective angiopoietin 1/2-neutralizing peptibody, inhibits angiogenesis in models of ocular neovascular diseases

Investigative ophthalmology & visual science, 2012-04, Vol.53 (4), p.2170-2180

2012

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Abstract 1022: Development and preclinical testing of AMG 780, a fully human antibody targeting angiopoietin 1 (Ang1) and angiopoietin 2 (Ang2)

Cancer research (Chicago, Ill.), 2014-10, Vol.74 (19_Supplement), p.1022-1022

2014

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Abstract 5089: Combined treatment of trebananib (AMG 386) with panitumumab in preclinical tumor models

Cancer research (Chicago, Ill.), 2013-04, Vol.73 (8_Supplement), p.5089-5089

2013

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Regulation of brain capillary endothelial thrombomodulin mRNA expression

Stroke (1970), 1996-12, Vol.27 (12), p.2304-2311

1996

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Abstract A182: U3–1287 (AMG 888), a fully human anti-HER3 mAb, demonstrates in vitro and in vivo efficacy in the FaDu model of human squamous cell carcinoma of the head and neck (SCCHN)

Molecular cancer therapeutics, 2011-11, Vol.10 (11_Supplement), p.A182-A182

2011

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Pyridyl-pyrimidine benzimidazole derivatives as potent, selective, and orally bioavailable inhibitors of Tie-2 kinase

Bioorganic & medicinal chemistry letters, 2009-01, Vol.19 (2), p.424-427

2009

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Astrocyte Growth Stimulation by a Soluble Factor Produced by Cerebral Endothelial Cellsin vitro

Journal of neuropathology and experimental neurology, 1990-11, Vol.49 (6), p.539-549

1990

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Evaluation of indazole-based compounds as a new class of potent KDR/VEGFR-2 inhibitors

Bioorganic & medicinal chemistry, 2008-09, Vol.18 (17), p.4844-4848

2008

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Discovery of N-phenyl nicotinamides as potent inhibitors of Kdr

Bioorganic & medicinal chemistry letters, 2007-11, Vol.17 (21), p.6003-6008

2007

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Alkynylpyrimidine Amide Derivatives as Potent, Selective, and Orally Active Inhibitors of Tie-2 Kinase

Journal of medicinal chemistry, 2007-02, Vol.50 (4), p.627-640

2007

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Detection of platelet-derived growth factor (PDGF)-AA in actively healing human wounds treated with recombinant PDGF-BB and absence of PDGF in chronic nonhealing wounds

The Journal of clinical investigation, 1995-09, Vol.96 (3), p.1336-1350

1995

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Uptake of Glucose Analogues into Cultured Cerebral Microvessel Endothelium

Journal of neuropathology and experimental neurology, 1985-09, Vol.44 (5), p.445-458

1985

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Spontaneous Spongy Degeneration of the Mouse Brain

Journal of neuropathology and experimental neurology, 1984-03, Vol.43 (2), p.118-130

1984

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Expression of mRNA for Glial Fibrillary Acidic Protein after Experimental Cerebral Injury

Journal of neuropathology and experimental neurology, 1992-09, Vol.51 (5), p.560-565

1992

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Choline Uptake by Cerebral Capillary Endothelial Cells in Culture

Journal of neurochemistry, 1990-05, Vol.54 (5), p.1467-1473

1990

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Complementary Actions of Inhibitors of Angiopoietin-2 and VEGF on Tumor Angiogenesis and Growth

Contrasting Actions of Selective Inhibitors of Angiopoietin-1 and Angiopoietin-2 on the Normalization of Tumor Blood Vessels

Context-dependent role of angiopoietin-1 inhibition in the suppression of angiogenesis and tumor growth: implications for AMG 386, an angiopoietin-1/2-neutralizing peptibody

Evolution of a Highly Selective and Potent 2-(Pyridin-2-yl)-1,3,5-triazine Tie-2 Kinase Inhibitor

Keratinocyte growth factor protects mice from chemotherapy and radiation-induced gastrointestinal injury and mortality

The Antiproliferative Activity of c-myb and c-myc Antisense Oligonucleotides in Smooth Muscle Cells is Caused by a Nonantisense Mechanism

Stimulatory Effects of B7-Related Protein-1 on Cellular and Humoral Immune Responses in Mice

AMG 706, an oral, multikinase inhibitor that selectively targets vascular endothelial growth factor, platelet-derived growth factor, and kit receptors, potently inhibits angiogenesis and induces regression in tumor xenografts

AMG 386, a selective angiopoietin 1/2-neutralizing peptibody, inhibits angiogenesis in models of ocular neovascular diseases

Abstract 1022: Development and preclinical testing of AMG 780, a fully human antibody targeting angiopoietin 1 (Ang1) and angiopoietin 2 (Ang2)

Abstract 5089: Combined treatment of trebananib (AMG 386) with panitumumab in preclinical tumor models

Regulation of brain capillary endothelial thrombomodulin mRNA expression

Abstract A182: U3–1287 (AMG 888), a fully human anti-HER3 mAb, demonstrates in vitro and in vivo efficacy in the FaDu model of human squamous cell carcinoma of the head and neck (SCCHN)

Naphthamides as Novel and Potent Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitors: Design, Synthesis, and Evaluation

Pyridyl-pyrimidine benzimidazole derivatives as potent, selective, and orally bioavailable inhibitors of Tie-2 kinase

Astrocyte Growth Stimulation by a Soluble Factor Produced by Cerebral Endothelial Cellsin vitro

Evaluation of indazole-based compounds as a new class of potent KDR/VEGFR-2 inhibitors

Evaluation of a Series of Naphthamides as Potent, Orally Active Vascular Endothelial Growth Factor Receptor-2 Tyrosine Kinase Inhibitors

Discovery of N-phenyl nicotinamides as potent inhibitors of Kdr

Alkynylpyrimidine Amide Derivatives as Potent, Selective, and Orally Active Inhibitors of Tie-2 Kinase

Detection of platelet-derived growth factor (PDGF)-AA in actively healing human wounds treated with recombinant PDGF-BB and absence of PDGF in chronic nonhealing wounds

Uptake of Glucose Analogues into Cultured Cerebral Microvessel Endothelium

Spontaneous Spongy Degeneration of the Mouse Brain

Expression of mRNA for Glial Fibrillary Acidic Protein after Experimental Cerebral Injury

Choline Uptake by Cerebral Capillary Endothelial Cells in Culture

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