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A novel dual glucagon‐like peptide and glucagon receptor agonist SAR425899: Results of randomized, placebo‐controlled first‐in‐human and first‐in‐patient trials

Diabetes, obesity & metabolism, 2019-01, Vol.21 (1), p.120-128

2019

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Design of Novel Exendin-Based Dual Glucagon-like Peptide 1 (GLP-1)/Glucagon Receptor Agonists

Journal of medicinal chemistry, 2017-05, Vol.60 (10), p.4293-4303

2017

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Running on mixed fuel‐dual agonistic approach of GLP‐1 and GCG receptors leads to beneficial impact on body weight and blood glucose control: A comparative study between mice and non‐human primates

Diabetes, obesity & metabolism, 2018-08, Vol.20 (8), p.1836-1851

2018

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Team Players or Opponents: Coadministration of Selective Glucagon and GLP-1 Receptor Agonists in Obese Diabetic Monkeys

Endocrinology (Philadelphia), 2018-08, Vol.159 (8), p.3105-3119

2018

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Imaging of the Glucose-Dependent Insulinotropic Polypeptide Receptor Using a Novel Radiolabeled Peptide Rationally Designed Based on Endogenous GIP and Synthetic Exendin-4 Sequences

Pharmaceuticals (Basel, Switzerland), 2023-01, Vol.16 (1), p.61

2023

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First-in-class positron emission tomography tracer for the glucagon receptor

EJNMMI research, 2019-02, Vol.9 (1), p.17-13, Article 17

2019

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Automated GMP-Compliant Production of [68Ga]Ga-DO3A-Tuna-2 for PET Microdosing Studies of the Glucagon Receptor in Humans

Pharmaceuticals (Basel, Switzerland), 2020-07, Vol.13 (8), p.176

2020

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Studies on the Synthesis of Apoptolidin A. 1. Synthesis of the C(1)−C(11) Fragment

Journal of organic chemistry, 2008-02, Vol.73 (3), p.1031-1035

2008

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Occupancy of Glucagon Like Peptide-1 receptor by Tirzepatide and SAR441255 measured with [68Ga]Ga-DO3A-exendin-4/PET in vivo

Nuclear medicine and biology, 2023-11, Vol.126-127, p.108662, Article 108662

2023

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Introduction of a fatty acid chain modification to prolong circulatory half-life of a radioligand towards glucose-dependent insulinotropic polypeptide receptor

Nuclear medicine and biology, 2024-01, Vol.128-129, p.108876, Article 108876

2024

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[68Ga]Ga-DOTA-GIP1234 for PET imaging of glucose-dependent insulinotropic polypeptide receptor (GIPR)

Nuclear medicine and biology, 2023-11, Vol.126-127, p.108656, Article 108656

2023

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Synthesis of Biaryls by Intramolecular Radical Aryl Migration from Silicon to Carbon

Organic letters, 2000-04, Vol.2 (7), p.985-988

2000

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Radical aryl migration reactions

Tetrahedron, 2001-11, Vol.57 (48), p.9649-9667

2001

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Dual Glucagon-like Peptide 1 (GLP-1)/Glucagon Receptor Agonists Specifically Optimized for Multidose Formulations

Journal of medicinal chemistry, 2018-07, Vol.61 (13), p.5580-5593

2018

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Drug Occupancy Assessment at the Glucose-Dependent Insulinotropic Polypeptide Receptor by Positron Emission Tomography

Diabetes (New York, N.Y.), 2021-04, Vol.70 (4), p.842-853

2021

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Peptide Optimization at the Drug Discovery-Development Interface: Tailoring of Physicochemical Properties Toward Specific Formulation Requirements

Journal of pharmaceutical sciences, 2019-04, Vol.108 (4), p.1404-1414

2019

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Glucagon Like Peptide-1 receptor imaging in individuals with Type 2 Diabetes

Journal of Nuclear Medicine, 2021-09, p.jnumed.121.262506

2021

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Glucagonlike Peptide-1 Receptor Imaging in Individuals with Type 2 Diabetes

The Journal of nuclear medicine (1978), 2022-05, Vol.63 (5), p.794-800

2022

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Incretin combination therapy for the treatment of non‐alcoholic steatohepatitis

Diabetes, obesity & metabolism, 2020-08, Vol.22 (8), p.1328-1338

2020

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Imaging of the Glucagon Receptor in Subjects with Type 2 Diabetes

Journal of Nuclear Medicine, 2021-06, Vol.62 (6), p.833-838

2021

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Assessment of glucagon receptor occupancy by Positron Emission Tomography in non-human primates

Scientific reports, 2019-10, Vol.9 (1), p.14960, Article 14960

2019

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Weight Loss Outcomes with Species-Specific Dual GLP-1R/GCGR Agonists in Animal Models

Diabetes (New York, N.Y.), 2018-07, Vol.67 (Supplement_1)

2018

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European Medicinal Chemistry Leaders in Industry (EMCL) – On the Status and Future of Medicinal Chemistry Research in Europe

ChemMedChem, 2023-07, Vol.18 (13), p.e202300127-n/a

2023

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Correction to Design of Novel Exendin-Based Dual Glucagon-like Peptide 1 (GLP-1)/Glucagon Receptor Agonist

Journal of medicinal chemistry, 2017-07, Vol.60 (13), p.5941-5941

2017

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A novel dual glucagon‐like peptide and glucagon receptor agonist SAR425899: Results of randomized, placebo‐controlled first‐in‐human and first‐in‐patient trials

Design of Novel Exendin-Based Dual Glucagon-like Peptide 1 (GLP-1)/Glucagon Receptor Agonists

Running on mixed fuel‐dual agonistic approach of GLP‐1 and GCG receptors leads to beneficial impact on body weight and blood glucose control: A comparative study between mice and non‐human primates

Team Players or Opponents: Coadministration of Selective Glucagon and GLP-1 Receptor Agonists in Obese Diabetic Monkeys

Imaging of the Glucose-Dependent Insulinotropic Polypeptide Receptor Using a Novel Radiolabeled Peptide Rationally Designed Based on Endogenous GIP and Synthetic Exendin-4 Sequences

First-in-class positron emission tomography tracer for the glucagon receptor

Automated GMP-Compliant Production of [68Ga]Ga-DO3A-Tuna-2 for PET Microdosing Studies of the Glucagon Receptor in Humans

Studies on the Synthesis of Apoptolidin A. 1. Synthesis of the C(1)−C(11) Fragment

Occupancy of Glucagon Like Peptide-1 receptor by Tirzepatide and SAR441255 measured with [68Ga]Ga-DO3A-exendin-4/PET in vivo

Effects on weight loss and glycemic control with SAR441255, a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist

Introduction of a fatty acid chain modification to prolong circulatory half-life of a radioligand towards glucose-dependent insulinotropic polypeptide receptor

[68Ga]Ga-DOTA-GIP1234 for PET imaging of glucose-dependent insulinotropic polypeptide receptor (GIPR)

Synthesis of Biaryls by Intramolecular Radical Aryl Migration from Silicon to Carbon

Radical aryl migration reactions

Dual Glucagon-like Peptide 1 (GLP-1)/Glucagon Receptor Agonists Specifically Optimized for Multidose Formulations

Drug Occupancy Assessment at the Glucose-Dependent Insulinotropic Polypeptide Receptor by Positron Emission Tomography

Peptide Optimization at the Drug Discovery-Development Interface: Tailoring of Physicochemical Properties Toward Specific Formulation Requirements

Glucagon Like Peptide-1 receptor imaging in individuals with Type 2 Diabetes

Glucagonlike Peptide-1 Receptor Imaging in Individuals with Type 2 Diabetes

Incretin combination therapy for the treatment of non‐alcoholic steatohepatitis

Imaging of the Glucagon Receptor in Subjects with Type 2 Diabetes

Assessment of glucagon receptor occupancy by Positron Emission Tomography in non-human primates

Weight Loss Outcomes with Species-Specific Dual GLP-1R/GCGR Agonists in Animal Models

European Medicinal Chemistry Leaders in Industry (EMCL) – On the Status and Future of Medicinal Chemistry Research in Europe

Correction to Design of Novel Exendin-Based Dual Glucagon-like Peptide 1 (GLP-1)/Glucagon Receptor Agonist

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