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Why the Dose Matters: Assessing the Health Risk of Exposure to Toxicants

Boelsterli, Urs A.

1, 2023

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Mechanisms of isoniazid-induced idiosyncratic liver injury: Emerging role of mitochondrial stress

Journal of gastroenterology and hepatology, 2014-04, Vol.29 (4), p.678-687

2014

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Multiple NSAID-induced hits injure the small intestine: underlying mechanisms and novel strategies

Toxicological sciences, 2013-02, Vol.131 (2), p.654-667

2013

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Acetaminophen overdose‐induced liver injury in mice is mediated by peroxynitrite independently of the cyclophilin D‐regulated permeability transition

Hepatology (Baltimore, Md.), 2011-09, Vol.54 (3), p.969-978

2011

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Mitochondrial abnormalities—A link to idiosyncratic drug hepatotoxicity?

Toxicology and applied pharmacology, 2007-04, Vol.220 (1), p.92-107

2007

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Understanding and modulating mammalian-microbial communication for improved human health

Annual review of pharmacology and toxicology, 2014-01, Vol.54 (1), p.559-580

2014

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NSAID acyl glucuronides and enteropathy

Current drug metabolism, 2011-03, Vol.12 (3), p.245-252

2011

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Bypassing the compromised mitochondrial electron transport with methylene blue alleviates efavirenz/isoniazid-induced oxidant stress and mitochondria-mediated cell death in mouse hepatocytes

Redox biology, 2014, Vol.2 (C), p.599-609

2014

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Isoniazid-induced cell death is precipitated by underlying mitochondrial complex I dysfunction in mouse hepatocytes

Free radical biology & medicine, 2013-12, Vol.65, p.584-594

2013

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Mitochondrial protection by the JNK inhibitor leflunomide rescues mice from acetaminophen‐induced liver injury

Hepatology (Baltimore, Md.), 2007-02, Vol.45 (2), p.412-421

2007

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Mechanisms of cell death pathway activation following drug-induced inhibition of mitochondrial complex I

Redox biology, 2015-04, Vol.4 (C), p.279-288

2015

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Protection from diclofenac-induced small intestinal injury by the JNK inhibitor SP600125 in a mouse model of NSAID-associated enteropathy

American journal of physiology: Gastrointestinal and liver physiology, 2009-11, Vol.297 (5), p.G990-G998

2009

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Integrative Toxicoproteomics Implicates Impaired Mitochondrial Glutathione Import as an Off-Target Effect of Troglitazone

Journal of proteome research, 2013-06, Vol.12 (6), p.2933-2945

2013

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Underlying mitochondrial dysfunction triggers flutamide-induced oxidative liver injury in a mouse model of idiosyncratic drug toxicity

Toxicology and applied pharmacology, 2009-07, Vol.238 (2), p.150-159

2009

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Pharmacologic Targeting or Genetic Deletion of Mitochondrial Cyclophilin D Protects from NSAID-Induced Small Intestinal Ulceration in Mice

Toxicological sciences, 2010-11, Vol.118 (1), p.276-285

2010

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The Mitochondrial Superoxide/Thioredoxin-2/Ask1 Signaling Pathway is Critically Involved in Troglitazone-Induced Cell Injury to Human Hepatocytes

Toxicological sciences, 2008-02, Vol.101 (2), p.341-349

2008

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Pharmacologic targeting of bacterial β-glucuronidase alleviates nonsteroidal anti-inflammatory drug-induced enteropathy in mice

The Journal of pharmacology and experimental therapeutics, 2012-05, Vol.341 (2), p.447-454

2012

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Troglitazone-induced hepatic mitochondrial proteome expression dynamics in heterozygous Sod2 +/− mice: Two-stage oxidative injury

Toxicology and applied pharmacology, 2008-08, Vol.231 (1), p.43-51

2008

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Bacterial β-glucuronidase inhibition protects mice against enteropathy induced by indomethacin, ketoprofen or diclofenac: mode of action and pharmacokinetics

Xenobiotica, 2014-01, Vol.44 (1), p.28-35

2014

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Targeting mitochondria with methylene blue protects mice against acetaminophen‐induced liver injury

Hepatology (Baltimore, Md.), 2015-01, Vol.61 (1), p.326-336

2015

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Diclofenac-induced liver injury: a paradigm of idiosyncratic drug toxicity

Toxicology and Applied Pharmacology, 2003-11, Vol.192 (3), p.307-322

Boelsterli, Urs A

2003

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ANIMAL MODELS OF HUMAN DISEASE IN DRUG SAFETY ASSESSMENT

The Journal of Toxicological Sciences, 2003, Vol.28(3), pp.109-121

Boelsterli, Urs A.

2003

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Leflunomide or A77 1726 protect from acetaminophen-induced cell injury through inhibition of JNK-mediated mitochondrial permeability transition in immortalized human hepatocytes

Toxicology and applied pharmacology, 2006-11, Vol.217 (1), p.125-133

2006

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Proteomics profiling of hepatic mitochondria in heterozygous Sod2+/− mice, an animal model of discreet mitochondrial oxidative stress

Proteomics (Weinheim), 2008-02, Vol.8 (3), p.555-568

2008

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Troglitazone-Induced Hepatic Necrosis in an Animal Model of Silent Genetic Mitochondrial Abnormalities

Toxicological sciences, 2007-05, Vol.97 (1), p.205-213

2007

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Why the Dose Matters: Assessing the Health Risk of Exposure to Toxicants

Mechanisms of isoniazid-induced idiosyncratic liver injury: Emerging role of mitochondrial stress

Multiple NSAID-induced hits injure the small intestine: underlying mechanisms and novel strategies

Acetaminophen overdose‐induced liver injury in mice is mediated by peroxynitrite independently of the cyclophilin D‐regulated permeability transition

Mitochondrial abnormalities—A link to idiosyncratic drug hepatotoxicity?

Understanding and modulating mammalian-microbial communication for improved human health

NSAID acyl glucuronides and enteropathy

Bypassing the compromised mitochondrial electron transport with methylene blue alleviates efavirenz/isoniazid-induced oxidant stress and mitochondria-mediated cell death in mouse hepatocytes

Isoniazid-induced cell death is precipitated by underlying mitochondrial complex I dysfunction in mouse hepatocytes

Mitochondrial protection by the JNK inhibitor leflunomide rescues mice from acetaminophen‐induced liver injury

Mechanisms of cell death pathway activation following drug-induced inhibition of mitochondrial complex I

Protection from diclofenac-induced small intestinal injury by the JNK inhibitor SP600125 in a mouse model of NSAID-associated enteropathy

Integrative Toxicoproteomics Implicates Impaired Mitochondrial Glutathione Import as an Off-Target Effect of Troglitazone

Underlying mitochondrial dysfunction triggers flutamide-induced oxidative liver injury in a mouse model of idiosyncratic drug toxicity

Pharmacologic Targeting or Genetic Deletion of Mitochondrial Cyclophilin D Protects from NSAID-Induced Small Intestinal Ulceration in Mice

The Mitochondrial Superoxide/Thioredoxin-2/Ask1 Signaling Pathway is Critically Involved in Troglitazone-Induced Cell Injury to Human Hepatocytes

Pharmacologic targeting of bacterial β-glucuronidase alleviates nonsteroidal anti-inflammatory drug-induced enteropathy in mice

Troglitazone-induced hepatic mitochondrial proteome expression dynamics in heterozygous Sod2 +/− mice: Two-stage oxidative injury

Bacterial β-glucuronidase inhibition protects mice against enteropathy induced by indomethacin, ketoprofen or diclofenac: mode of action and pharmacokinetics

Targeting mitochondria with methylene blue protects mice against acetaminophen‐induced liver injury

Diclofenac-induced liver injury: a paradigm of idiosyncratic drug toxicity

ANIMAL MODELS OF HUMAN DISEASE IN DRUG SAFETY ASSESSMENT

Leflunomide or A77 1726 protect from acetaminophen-induced cell injury through inhibition of JNK-mediated mitochondrial permeability transition in immortalized human hepatocytes

Proteomics profiling of hepatic mitochondria in heterozygous Sod2+/− mice, an animal model of discreet mitochondrial oxidative stress

Troglitazone-Induced Hepatic Necrosis in an Animal Model of Silent Genetic Mitochondrial Abnormalities

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