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Novel Vanilloid Receptor-1 Antagonists: 2. Structure−Activity Relationships of 4-Oxopyrimidines Leading to the Selection of a Clinical Candidate

Journal of medicinal chemistry, 2007-07, Vol.50 (15), p.3515-3527

2007

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Synthesis and structure–activity relationships of dual PI3K/mTOR inhibitors based on a 4-amino-6-methyl-1,3,5-triazine sulfonamide scaffold

Bioorganic & medicinal chemistry letters, 2012-09, Vol.22 (17), p.5714-5720

2012

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Discovery of Potent, Orally Available Vanilloid Receptor-1 Antagonists. Structure−Activity Relationship of N-Aryl Cinnamides

Journal of medicinal chemistry, 2005-01, Vol.48 (1), p.71-90

2005

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Design of Potent, Orally Available Antagonists of the Transient Receptor Potential Vanilloid 1. Structure−Activity Relationships of 2-Piperazin-1-yl-1H-benzimidazoles

Journal of medicinal chemistry, 2006-06, Vol.49 (12), p.3719-3742

2006

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Structure-Based Design of a Novel Series of Potent, Selective Inhibitors of the Class I Phosphatidylinositol 3-Kinases

Journal of medicinal chemistry, 2012-06, Vol.55 (11), p.5188-5219

2012

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Novel Vanilloid Receptor-1 Antagonists: 1. Conformationally Restricted Analogues of trans-Cinnamides

Journal of medicinal chemistry, 2007-07, Vol.50 (15), p.3497-3514

2007

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Correction to Selective Class I Phosphoinositide 3‑Kinase Inhibitors: Optimization of a Series of Pyridyltriazines Leading to the Identification of a Clinical Candidate, AMG 511

Journal of medicinal chemistry, 2012-10, Vol.55 (20), p.8975-8975

2012

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Substituted aryl pyrimidines as potent and soluble TRPV1 antagonists

Bioorganic & medicinal chemistry, 2008-09, Vol.18 (18), p.5118-5122

2008

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Highly Enantioselective Phase Transfer Catalyzed Alkylation of a 3-Oxygenated Propionic Ester Equivalent; Applications and Mechanism

Journal of the American Chemical Society, 1998-12, Vol.120 (49), p.13000-13001

1998

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Enantioselective Total Synthesis of Aspidophytine

Journal of the American Chemical Society, 1999-07, Vol.121 (28), p.6771-6772

1999

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Synthesis and evaluation of thiazole carboxamides as vanilloid receptor 1 (TRPV1) antagonists

Bioorganic & medicinal chemistry letters, 2005-12, Vol.15 (23), p.5211-5217

2005

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Melanocortin subtype-4 receptor agonists containing a piperazine core with substituted aryl sulfonamides

Bioorganic & medicinal chemistry letters, 2005-03, Vol.15 (6), p.1623-1627

2005

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New, practical and effective sources of fluoride ion for desilylation to form carbon anions

Tetrahedron letters, 1999-03, Vol.40 (11), p.2065-2068

1999

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The imidazo[1,2-a]pyridine ring system as a scaffold for potent dual phosphoinositide-3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitors

Bioorganic & medicinal chemistry letters, 2015-10, Vol.25 (19), p.4136-4142

2015

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Fused Piperidines as a Novel Class of Potent and Orally Available Transient Receptor Potential Melastatin Type 8 (TRPM8) Antagonists

Journal of medicinal chemistry, 2012-02, Vol.55 (4), p.1593-1611

2012

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Phospshoinositide 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Dual Inhibitors: Discovery and Structure–Activity Relationships of a Series of Quinoline and Quinoxaline Derivatives

Journal of medicinal chemistry, 2011-07, Vol.54 (13), p.4735-4751

2011

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Optimization of Potency and Pharmacokinetic Properties of Tetrahydroisoquinoline Transient Receptor Potential Melastatin 8 (TRPM8) Antagonists

Journal of medicinal chemistry, 2014-04, Vol.57 (7), p.2989-3004

2014

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Small Molecule Disruptors of the Glucokinase–Glucokinase Regulatory Protein Interaction: 5. A Novel Aryl Sulfone Series, Optimization Through Conformational Analysis

Journal of medicinal chemistry, 2015-06, Vol.58 (11), p.4462-4482

2015

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Synthese von Heterocyclen durch Tandem-reaktionen: Beckmann-Umlagerungen/Allylsilan-Cyclisierungen

Angewandte Chemie, 1991-06, Vol.103 (6), p.727-728

1991

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Synthesis of Heterocycles by Tandem Reactions: Beckmann Rearrangements/Allylsilane Cyclizations

Angewandte Chemie (International ed.), 1991-06, Vol.30 (6), p.687-688

1991

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A facile and efficient method for macrolactamization

Tetrahedron letters, 1990, Vol.31 (15), p.2161-2164

1990

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Design of Potent, Orally Available Antagonists of the Transient Receptor Potential Vanilloid 1. Structure−Activity Relationships of 2-Piperazin-1-yl-1 H -benzimidazoles

Journal of medicinal chemistry, 2006-06, Vol.49 (12), p.3719-3742

2006

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Synthesis and X-ray crystal structure of (−)-calicheamicinone

Tetrahedron, 1999-03, Vol.55 (11), p.3277-3290

1999

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Synthesis of (±)-Calicheamicinone by Two Methods

Journal of the American Chemical Society, 1998-10, Vol.120 (40), p.10332-10349

1998

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Selective Class I Phosphoinositide 3‑Kinase Inhibitors: Optimization of a Series of Pyridyltriazines Leading to the Identification of a Clinical Candidate, AMG 511

Novel Vanilloid Receptor-1 Antagonists: 2. Structure−Activity Relationships of 4-Oxopyrimidines Leading to the Selection of a Clinical Candidate

Synthesis and structure–activity relationships of dual PI3K/mTOR inhibitors based on a 4-amino-6-methyl-1,3,5-triazine sulfonamide scaffold

Discovery of Potent, Orally Available Vanilloid Receptor-1 Antagonists. Structure−Activity Relationship of N-Aryl Cinnamides

Design of Potent, Orally Available Antagonists of the Transient Receptor Potential Vanilloid 1. Structure−Activity Relationships of 2-Piperazin-1-yl-1H-benzimidazoles

Structure-Based Design of a Novel Series of Potent, Selective Inhibitors of the Class I Phosphatidylinositol 3-Kinases

Novel Vanilloid Receptor-1 Antagonists: 1. Conformationally Restricted Analogues of trans-Cinnamides

Correction to Selective Class I Phosphoinositide 3‑Kinase Inhibitors: Optimization of a Series of Pyridyltriazines Leading to the Identification of a Clinical Candidate, AMG 511

Substituted aryl pyrimidines as potent and soluble TRPV1 antagonists

Highly Enantioselective Phase Transfer Catalyzed Alkylation of a 3-Oxygenated Propionic Ester Equivalent; Applications and Mechanism

Enantioselective Total Synthesis of Aspidophytine

Synthesis and evaluation of thiazole carboxamides as vanilloid receptor 1 (TRPV1) antagonists

Melanocortin subtype-4 receptor agonists containing a piperazine core with substituted aryl sulfonamides

New, practical and effective sources of fluoride ion for desilylation to form carbon anions

The imidazo[1,2-a]pyridine ring system as a scaffold for potent dual phosphoinositide-3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitors

Fused Piperidines as a Novel Class of Potent and Orally Available Transient Receptor Potential Melastatin Type 8 (TRPM8) Antagonists

Phospshoinositide 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Dual Inhibitors: Discovery and Structure–Activity Relationships of a Series of Quinoline and Quinoxaline Derivatives

Optimization of Potency and Pharmacokinetic Properties of Tetrahydroisoquinoline Transient Receptor Potential Melastatin 8 (TRPM8) Antagonists

Small Molecule Disruptors of the Glucokinase–Glucokinase Regulatory Protein Interaction: 5. A Novel Aryl Sulfone Series, Optimization Through Conformational Analysis

Synthese von Heterocyclen durch Tandem-reaktionen: Beckmann-Umlagerungen/Allylsilan-Cyclisierungen

Synthesis of Heterocycles by Tandem Reactions: Beckmann Rearrangements/Allylsilane Cyclizations

A facile and efficient method for macrolactamization

Design of Potent, Orally Available Antagonists of the Transient Receptor Potential Vanilloid 1. Structure−Activity Relationships of 2-Piperazin-1-yl-1 H -benzimidazoles

Synthesis and X-ray crystal structure of (−)-calicheamicinone

Synthesis of (±)-Calicheamicinone by Two Methods

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