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A nanoluciferase SARS-CoV-2 for rapid neutralization testing and screening of anti-infective drugs for COVID-19

Nature communications, 2020-10, Vol.11 (1), p.5214-5214, Article 5214

2020

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Oral prodrug of remdesivir parent GS-441524 is efficacious against SARS-CoV-2 in ferrets

Nature communications, 2021-11, Vol.12 (1), p.6415-6415, Article 6415

2021

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Key Metabolic Enzymes Involved in Remdesivir Activation in Human Lung Cells

Antimicrobial agents and chemotherapy, 2021-08, Vol.65 (9), p.e0060221-e0060221

2021

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Epstein-Barr virus microRNAs are evolutionarily conserved and differentially expressed

PLoS pathogens, 2006-03, Vol.2 (3), p.e23-e23

2006

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Structural basis for substrate selection by the SARS-CoV-2 replicase

Nature (London), 2023-02, Vol.614 (7949), p.781-787

2023

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The Nucleoside/Nucleotide Analogs Tenofovir and Emtricitabine Are Inactive against SARS-CoV-2

Molecules (Basel, Switzerland), 2022-06, Vol.27 (13), p.4212

2022

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Author Correction: A nanoluciferase SARS-CoV-2 for rapid neutralization testing and screening of anti-infective drugs for COVID-19

Nature communications, 2021-06, Vol.12 (1), p.3984-3984, Article 3984

2021

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Spike mutation D614G alters SARS-CoV-2 fitness

Nature (London), 2021-04, Vol.592 (7852), p.116-121

2021

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Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase in Mice

Cell reports (Cambridge), 2020-07, Vol.32 (3), p.107940-107940, Article 107940

2020

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Remdesivir and GS-441524 Retain Antiviral Activity against Delta, Omicron, and Other Emergent SARS-CoV-2 Variants

Antimicrobial agents and chemotherapy, 2022-06, Vol.66 (6), p.e0022222-e0022222

2022

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An atomistic model of the coronavirus replication-transcription complex as a hexamer assembled around nsp15

The Journal of biological chemistry, 2021-10, Vol.297 (4), p.101218-101218, Article 101218

2021

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Vaccine Protection against Simian Immunodeficiency Virus in Monkeys Using Recombinant Gamma-2 Herpesvirus

Journal of Virology, 2011-12, Vol.85 (23), p.12708-12720

2011

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Efficient incorporation and template-dependent polymerase inhibition are major determinants for the broad-spectrum antiviral activity of remdesivir

The Journal of biological chemistry, 2022-02, Vol.298 (2), p.101529-101529, Article 101529

2022

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A robust SARS-CoV-2 replication model in primary human epithelial cells at the air liquid interface to assess antiviral agents

Antiviral research, 2021-08, Vol.192, p.105122-105122, Article 105122

2021

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Therapeutic treatment with an oral prodrug of the remdesivir parental nucleoside is protective against SARS-CoV-2 pathogenesis in mice

Science translational medicine, 2022-05, Vol.14 (643), p.eabm3410

2022

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Inhaled remdesivir reduces viral burden in a nonhuman primate model of SARS-CoV-2 infection

Science translational medicine, 2022-02, Vol.14 (633), p.eabl8282

2022

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Mechanism and spectrum of inhibition of a 4′-cyano modified nucleotide analog against diverse RNA polymerases of prototypic respiratory RNA viruses

The Journal of biological chemistry, 2024-08, Vol.300 (8), p.107514, Article 107514

2024

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Oral administration of obeldesivir protects nonhuman primates against Sudan ebolavirus

Science (American Association for the Advancement of Science), 2024-03, Vol.383 (6688), p.eadk6176-eadk6176

2024

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Efficient Incorporation and Template‐Dependent Polymerase Inhibition are Major Determinants for the Broad‐Spectrum Antiviral Activity of Remdesivir

The FASEB journal, 2022-05, Vol.36 (S1), p.n/a

2022

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Extreme Dependence of gH and gL Expression on ORF57 and Association with Highly Unusual Codon Usage in Rhesus Monkey Rhadinovirus

Journal of Virology, 2008-07, Vol.82 (14), p.7231-7237

2008

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Intravenous delivery of GS-441524 is efficacious in the African green monkey model of SARS-CoV-2 infection

Antiviral research, 2022-07, Vol.203, p.105329-105329, Article 105329

2022

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Discovery of GS-7682, a Novel 4′-Cyano-Modified C‑Nucleoside Prodrug with Broad Activity against Pneumo- and Picornaviruses and Efficacy in RSV-Infected African Green Monkeys

Journal of medicinal chemistry, 2024-08, Vol.67 (15), p.12945-12968

2024

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A nanoluciferase SARS-CoV-2 for rapid neutralization testing and screening of anti-infective drugs for COVID-19

Oral prodrug of remdesivir parent GS-441524 is efficacious against SARS-CoV-2 in ferrets

Key Metabolic Enzymes Involved in Remdesivir Activation in Human Lung Cells

Epstein-Barr virus microRNAs are evolutionarily conserved and differentially expressed

Structural basis for substrate selection by the SARS-CoV-2 replicase

The Nucleoside/Nucleotide Analogs Tenofovir and Emtricitabine Are Inactive against SARS-CoV-2

Author Correction: A nanoluciferase SARS-CoV-2 for rapid neutralization testing and screening of anti-infective drugs for COVID-19

Spike mutation D614G alters SARS-CoV-2 fitness

Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase in Mice

Remdesivir and GS-441524 Retain Antiviral Activity against Delta, Omicron, and Other Emergent SARS-CoV-2 Variants

An atomistic model of the coronavirus replication-transcription complex as a hexamer assembled around nsp15

Vaccine Protection against Simian Immunodeficiency Virus in Monkeys Using Recombinant Gamma-2 Herpesvirus

Efficient incorporation and template-dependent polymerase inhibition are major determinants for the broad-spectrum antiviral activity of remdesivir

A robust SARS-CoV-2 replication model in primary human epithelial cells at the air liquid interface to assess antiviral agents

Therapeutic treatment with an oral prodrug of the remdesivir parental nucleoside is protective against SARS-CoV-2 pathogenesis in mice

Prodrugs of a 1′-CN-4-Aza-7,9-dideazaadenosine C‑Nucleoside Leading to the Discovery of Remdesivir (GS-5734) as a Potent Inhibitor of Respiratory Syncytial Virus with Efficacy in the African Green Monkey Model of RSV

Inhaled remdesivir reduces viral burden in a nonhuman primate model of SARS-CoV-2 infection

Mechanism and spectrum of inhibition of a 4′-cyano modified nucleotide analog against diverse RNA polymerases of prototypic respiratory RNA viruses

Discovery of GS-5245 (Obeldesivir), an Oral Prodrug of Nucleoside GS-441524 That Exhibits Antiviral Efficacy in SARS-CoV-2-Infected African Green Monkeys

Oral administration of obeldesivir protects nonhuman primates against Sudan ebolavirus

Efficient Incorporation and Template‐Dependent Polymerase Inhibition are Major Determinants for the Broad‐Spectrum Antiviral Activity of Remdesivir

Extreme Dependence of gH and gL Expression on ORF57 and Association with Highly Unusual Codon Usage in Rhesus Monkey Rhadinovirus

Intravenous delivery of GS-441524 is efficacious in the African green monkey model of SARS-CoV-2 infection

Discovery of GS-7682, a Novel 4′-Cyano-Modified C‑Nucleoside Prodrug with Broad Activity against Pneumo- and Picornaviruses and Efficacy in RSV-Infected African Green Monkeys

The oral nucleoside prodrug GS-5245 is efficacious against SARS-CoV-2 and other endemic, epidemic, and enzootic coronaviruses

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