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Predicting Drug Concentration‐Time Profiles in Multiple CNS Compartments Using a Comprehensive Physiologically‐Based Pharmacokinetic Model

CPT: pharmacometrics and systems pharmacology, 2017-11, Vol.6 (11), p.765-777

2017

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A novel chemogenomics analysis of G protein-coupled receptors (GPCRs) and their ligands: a potential strategy for receptor de-orphanization

BMC bioinformatics, 2010-06, Vol.11 (1), p.316-316, Article 316

2010

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Internalization and desensitization of adenosine receptors

Purinergic signalling, 2008-03, Vol.4 (1), p.21-37

2008

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Prediction of human CNS pharmacokinetics using a physiologically-based pharmacokinetic modeling approach

European journal of pharmaceutical sciences, 2018-01, Vol.112, p.168-179

2018

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A two-entropies analysis to identify functional positions in the transmembrane region of class A G protein-coupled receptors

Proteins, structure, function, and bioinformatics, 2006-06, Vol.63 (4), p.1018-1030

2006

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ZM241385, DPCPX, MRS1706 are inverse agonists with different relative intrinsic efficacies on constitutively active mutants of the human adenosine A2B receptor

The Journal of pharmacology and experimental therapeutics, 2007-02, Vol.320 (2), p.637

2007

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Project management of life-science research projects: project characteristics, challenges and training needs

Drug discovery today, 2011-02, Vol.16 (3), p.93-98

Beukers, Margot W.

2011

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2-Amino-6-furan-2-yl-4-substituted Nicotinonitriles as A2A Adenosine Receptor Antagonists

Journal of medicinal chemistry, 2008-08, Vol.51 (15), p.4449-4455

2008

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Random Mutagenesis of the Human Adenosine A2B Receptor Followed by Growth Selection in Yeast. Identification of Constitutively Active and Gain of Function Mutations

Molecular pharmacology, 2004-03, Vol.65 (3), p.702

2004

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The endocannabinoid 2-arachidonylglycerol is a negative allosteric modulator of the human A3 adenosine receptor

Biochemical pharmacology, 2010-01, Vol.79 (1), p.48-56

2010

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GPCR structure and activation: an essential role for the first extracellular loop in activating the adenosine A₂B receptor

The FASEB journal, 2011-02, Vol.25 (2), p.632-643

2011

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A Series of Ligands Displaying a Remarkable Agonistic−Antagonistic Profile at the Adenosine A1 Receptor

Journal of medicinal chemistry, 2005-03, Vol.48 (6), p.2045-2053

2005

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A Prospective Cross-Screening Study on G-Protein-Coupled Receptors: Lessons Learned in Virtual Compound Library Design

Journal of medicinal chemistry, 2012-06, Vol.55 (11), p.5311-5325

2012

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Structure-affinity relationships of adenosine A2B receptor ligands

Medicinal research reviews, 2006-09, Vol.26 (5), p.667-698

2006

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Characterization of [3H]LUF5834: A novel non-ribose high-affinity agonist radioligand for the adenosine A1 receptor

Biochemical pharmacology, 2010-10, Vol.80 (8), p.1180-1189

2010

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2,4,6-Trisubstituted Pyrimidines as a New Class of Selective Adenosine A1 Receptor Antagonists

Journal of medicinal chemistry, 2004-12, Vol.47 (26), p.6529-6540

2004

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Techniques: how to boost GPCR mutagenesis studies using yeast

Trends in pharmacological sciences (Regular ed.), 2005-10, Vol.26 (10), p.533-539

2005

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A new generation of adenosine receptor antagonists: From di- to trisubstituted aminopyrimidines

Bioorganic & medicinal chemistry, 2008-03, Vol.16 (6), p.2741-2752

2008

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Synthesis and use of FSCPX, an irreversible adenosine A1 antagonist, as a 'Receptor knock-down' tool

Bioorganic & medicinal chemistry letters, 2001-03, Vol.11 (6), p.815-818

2001

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tGRAP, the G-protein coupled receptors mutant database

Nucleic acids research, 2002-01, Vol.30 (1), p.361

2002

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Allosteric modulators affect the internalization of human adenosine A1 receptors

European journal of pharmacology, 2005-10, Vol.522 (1-3), p.1-8

2005

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The endocannabinoid 2-arachidonylglycerol is a negative allosteric modulator of the human A adenosine receptor

Biochemical pharmacology, 2010-01, Vol.79 (1)

2010

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Modulation of agonist responses at the A1 adenosine receptor by an irreversible antagonist, receptor-G protein uncoupling and by the G protein activation state

Biochemical pharmacology, 2002-10, Vol.64 (8), p.1251-1265

2002

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New, Non-Adenosine, High-Potency Agonists for the Human Adenosine A 2B Receptor with an Improved Selectivity Profile Compared to the Reference Agonist N -Ethylcarboxamidoadenosine

Journal of medicinal chemistry, 2004-07, Vol.47 (15), p.3707-3709

2004

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New, Non-Adenosine, High-Potency Agonists for the Human Adenosine A2B Receptor with an Improved Selectivity Profile Compared to the Reference Agonist N-Ethylcarboxamidoadenosine

Journal of medicinal chemistry, 2004-07, Vol.47 (15), p.3707-3709

2004

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Predicting Drug Concentration‐Time Profiles in Multiple CNS Compartments Using a Comprehensive Physiologically‐Based Pharmacokinetic Model

A novel chemogenomics analysis of G protein-coupled receptors (GPCRs) and their ligands: a potential strategy for receptor de-orphanization

Internalization and desensitization of adenosine receptors

Prediction of human CNS pharmacokinetics using a physiologically-based pharmacokinetic modeling approach

A two-entropies analysis to identify functional positions in the transmembrane region of class A G protein-coupled receptors

ZM241385, DPCPX, MRS1706 are inverse agonists with different relative intrinsic efficacies on constitutively active mutants of the human adenosine A2B receptor

Project management of life-science research projects: project characteristics, challenges and training needs

2-Amino-6-furan-2-yl-4-substituted Nicotinonitriles as A2A Adenosine Receptor Antagonists

Random Mutagenesis of the Human Adenosine A2B Receptor Followed by Growth Selection in Yeast. Identification of Constitutively Active and Gain of Function Mutations

The endocannabinoid 2-arachidonylglycerol is a negative allosteric modulator of the human A3 adenosine receptor

GPCR structure and activation: an essential role for the first extracellular loop in activating the adenosine A₂B receptor

A Series of Ligands Displaying a Remarkable Agonistic−Antagonistic Profile at the Adenosine A1 Receptor

A Prospective Cross-Screening Study on G-Protein-Coupled Receptors: Lessons Learned in Virtual Compound Library Design

Structure-affinity relationships of adenosine A2B receptor ligands

Characterization of [3H]LUF5834: A novel non-ribose high-affinity agonist radioligand for the adenosine A1 receptor

2,4,6-Trisubstituted Pyrimidines as a New Class of Selective Adenosine A1 Receptor Antagonists

Techniques: how to boost GPCR mutagenesis studies using yeast

A new generation of adenosine receptor antagonists: From di- to trisubstituted aminopyrimidines

Synthesis and use of FSCPX, an irreversible adenosine A1 antagonist, as a 'Receptor knock-down' tool

tGRAP, the G-protein coupled receptors mutant database

Allosteric modulators affect the internalization of human adenosine A1 receptors

The endocannabinoid 2-arachidonylglycerol is a negative allosteric modulator of the human A adenosine receptor

Modulation of agonist responses at the A1 adenosine receptor by an irreversible antagonist, receptor-G protein uncoupling and by the G protein activation state

New, Non-Adenosine, High-Potency Agonists for the Human Adenosine A 2B Receptor with an Improved Selectivity Profile Compared to the Reference Agonist N -Ethylcarboxamidoadenosine

New, Non-Adenosine, High-Potency Agonists for the Human Adenosine A2B Receptor with an Improved Selectivity Profile Compared to the Reference Agonist N-Ethylcarboxamidoadenosine

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