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Organs-on-chips: into the next decade

Nature reviews. Drug discovery, 2021-05, Vol.20 (5), p.345-361

2021

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Perturbation of microRNAs in rat heart during chronic doxorubicin treatment

PloS one, 2012-07, Vol.7 (7), p.e40395

2012

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Workshop Report: FDA Workshop on Improving Cardiotoxicity Assessment With Human-Relevant Platforms

Circulation research, 2019-10, Vol.125 (9), p.855-867

2019

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A Structured Approach to Optimizing Animal Model Selection for Human Translation: The Animal Model Quality Assessment

ILAR journal, 2021-12, Vol.62 (1-2), p.66-76

2021

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Cancer Hazard Evaluations for Contemporary Needs: Highlights From New National Toxicology Program Evaluations and Methodological Advancements

JNCI : Journal of the National Cancer Institute, 2022-11, Vol.114 (11), p.1441-1448

2022

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Enabling novel paradigms: a biological questions-based approach to human chemical hazard and drug safety assessment

Toxicological sciences, 2024-02, Vol.198 (1), p.4-13

2024

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Microphysiological Systems: A Pathologist's Perspective

Veterinary pathology, 2020-05, Vol.57 (3), p.358

2020

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Key Characteristics of Cardiovascular Toxicants

Environmental health perspectives, 2021-09, Vol.129 (9), p.95001

2021

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Challenging the status quo: a framework for mechanistic and human-relevant cardiovascular safety screening

Frontiers in toxicology, 2024-03, Vol.6, p.1352783-1352783

2024

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Navigating tissue chips from development to dissemination: A pharmaceutical industry perspective

Experimental biology and medicine (Maywood, N.J.), 2017-10, Vol.242 (16), p.1579-1585

2017

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Current challenges in the evaluation of cardiac safety during drug development: Translational medicine meets the Critical Path Initiative

The American heart journal, 2009-09, Vol.158 (3), p.317-326

2009

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Digitalization of toxicology: improving preclinical to clinical translation

Frontiers in toxicology, 2024-03, Vol.6, p.1377542-1377542

2024

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Considerations for an In Vitro, Cell-Based Testing Platform for Detection of Drug-Induced Inotropic Effects in Early Drug Development. Part 2: Designing and Fabricating Microsystems for Assaying Cardiac Contractility With Physiological Relevance Using Human iPSC-Cardiomyocytes

Frontiers in pharmacology, 2019-08, Vol.10, p.934-934

2019

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National Toxicology Program Position Statement on Informed (“Nonblinded”) Analysis in Toxicologic Pathology Evaluation

Toxicologic pathology, 2019-10, Vol.47 (7), p.887-890

2019

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NIEHS: Making a Mark on Translational Research Science

Environmental health perspectives, 2018-08, Vol.126 (8), p.081001-081001

2018

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Adipsin, a Biomarker of Gastrointestinal Toxicity Mediated by a Functional γ-Secretase Inhibitor

The Journal of biological chemistry, 2003-11, Vol.278 (46), p.46107-46116

2003

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The Distinguished Legacy of Linda S. Birnbaum, an Environmental Health Champion

Environmental health perspectives, 2019-10, Vol.127 (10), p.101001

2019

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Considerations for an In Vitro , Cell-Based Testing Platform for Detection of Adverse Drug-Induced Inotropic Effects in Early Drug Development. Part 1: General Considerations for Development of Novel Testing Platforms

Frontiers in pharmacology, 2019-08, Vol.10, p.884-884

2019

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Non-proliferative and Proliferative Lesions of the Cardiovascular System of the Rat and Mouse

Journal of Toxicologic Pathology, 2016, Vol.29(3_Suppl), pp.1S-47S

2016

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Enhancing quality of life as a goal for anticancer therapeutics

Science translational medicine, 2016-06, Vol.8 (344), p.344ed9

2016

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High-Throughput Screening to Identify Chemical Cardiotoxic Potential

Chemical research in toxicology, 2021-02, Vol.34 (2), p.566-583

2021

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A translational approach to detecting drug-induced cardiac injury with cardiac troponins: Consensus and recommendations from the Cardiac Troponins Biomarker Working Group of the Health and Environmental Sciences Institute

The American heart journal, 2009-07, Vol.158 (1), p.21-29

2009

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Technological Advances in Cardiovascular Safety Assessment Decrease Preclinical Animal Use and Improve Clinical Relevance

ILAR journal, 2016-12, Vol.57 (2), p.120-132

2016

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Hepatic and glucagon-like peptide-1-mediated reversal of diabetes by glucagon receptor antisense oligonucleotide inhibitors

The Journal of clinical investigation, 2004-06, Vol.113 (11), p.1571-1581

2004

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A Novel Mouse Model to Analyze Non-Genomic ERα Physiological Actions

Journal of the Endocrine Society, 2022-09, Vol.6 (9), p.bvac109

2022

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Organs-on-chips: into the next decade

Perturbation of microRNAs in rat heart during chronic doxorubicin treatment

Workshop Report: FDA Workshop on Improving Cardiotoxicity Assessment With Human-Relevant Platforms

A Structured Approach to Optimizing Animal Model Selection for Human Translation: The Animal Model Quality Assessment

Cancer Hazard Evaluations for Contemporary Needs: Highlights From New National Toxicology Program Evaluations and Methodological Advancements

Enabling novel paradigms: a biological questions-based approach to human chemical hazard and drug safety assessment

Microphysiological Systems: A Pathologist's Perspective

Key Characteristics of Cardiovascular Toxicants

Challenging the status quo: a framework for mechanistic and human-relevant cardiovascular safety screening

Navigating tissue chips from development to dissemination: A pharmaceutical industry perspective

Current challenges in the evaluation of cardiac safety during drug development: Translational medicine meets the Critical Path Initiative

Digitalization of toxicology: improving preclinical to clinical translation

Considerations for an In Vitro, Cell-Based Testing Platform for Detection of Drug-Induced Inotropic Effects in Early Drug Development. Part 2: Designing and Fabricating Microsystems for Assaying Cardiac Contractility With Physiological Relevance Using Human iPSC-Cardiomyocytes

National Toxicology Program Position Statement on Informed (“Nonblinded”) Analysis in Toxicologic Pathology Evaluation

NIEHS: Making a Mark on Translational Research Science

Adipsin, a Biomarker of Gastrointestinal Toxicity Mediated by a Functional γ-Secretase Inhibitor

The Distinguished Legacy of Linda S. Birnbaum, an Environmental Health Champion

Considerations for an In Vitro , Cell-Based Testing Platform for Detection of Adverse Drug-Induced Inotropic Effects in Early Drug Development. Part 1: General Considerations for Development of Novel Testing Platforms

Non-proliferative and Proliferative Lesions of the Cardiovascular System of the Rat and Mouse

Enhancing quality of life as a goal for anticancer therapeutics

High-Throughput Screening to Identify Chemical Cardiotoxic Potential

A translational approach to detecting drug-induced cardiac injury with cardiac troponins: Consensus and recommendations from the Cardiac Troponins Biomarker Working Group of the Health and Environmental Sciences Institute

Technological Advances in Cardiovascular Safety Assessment Decrease Preclinical Animal Use and Improve Clinical Relevance

Hepatic and glucagon-like peptide-1-mediated reversal of diabetes by glucagon receptor antisense oligonucleotide inhibitors

A Novel Mouse Model to Analyze Non-Genomic ERα Physiological Actions

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