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Targeting protein prenylation for cancer therapy

Nature reviews. Cancer, 2011-11, Vol.11 (11), p.775-791

2011

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Advances of small molecule targeting of kinases

Current opinion in chemical biology, 2017-08, Vol.39, p.126-132

2017

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Dual Targeting of WEE1 and PLK1 by AZD1775 Elicits Single Agent Cellular Anticancer Activity

ACS chemical biology, 2017-07, Vol.12 (7), p.1883-1892

2017

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Potent Dual BET Bromodomain-Kinase Inhibitors as Value-Added Multitargeted Chemical Probes and Cancer Therapeutics

Molecular cancer therapeutics, 2017-06, Vol.16 (6), p.1054-1067

2017

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Measurement of protein farnesylation and geranylgeranylation in vitro, in cultured cells and in biopsies, and the effects of prenyl transferase inhibitors

Nature protocols, 2011-10, Vol.6 (11), p.1775-1791

2011

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Discovery of a novel proteasome inhibitor selective for cancer cells over non-transformed cells

Cell cycle (Georgetown, Tex.), 2009-06, Vol.8 (12), p.1940-1951

2009

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Marinopyrrole derivatives with sulfide spacers as selective disruptors of Mcl-1 binding to pro-apoptotic protein Bim

Marine drugs, 2014-07, Vol.12 (8), p.4311-4325

2014

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Protein phosphatase 1α-mediated stimulation of apoptosis is associated with dephosphorylation of the retinoblastoma protein

Oncogene, 2001-09, Vol.20 (43), p.6111-6122

2001

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Bivalent BET Bromodomain Inhibitors Confer Increased Potency and Selectivity for BRDT via Protein Conformational Plasticity

Journal of medicinal chemistry, 2022-08, Vol.65 (15), p.10441-10458

2022

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Structural Basis of Wee Kinases Functionality and Inactivation by Diverse Small Molecule Inhibitors

Journal of medicinal chemistry, 2017-09, Vol.60 (18), p.7863-7875

2017

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Differential BET Bromodomain Inhibition by Dihydropteridinone and Pyrimidodiazepinone Kinase Inhibitors

Journal of medicinal chemistry, 2021-11, Vol.64 (21), p.15772-15786

2021

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Acetyl-lysine Binding Site of Bromodomain-Containing Protein 4 (BRD4) Interacts with Diverse Kinase Inhibitors

ACS chemical biology, 2014-05, Vol.9 (5), p.1160-1171

2014

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Molecular Basis for the N‑Terminal Bromodomain-and-Extra-Terminal-Family Selectivity of a Dual Kinase–Bromodomain Inhibitor

Journal of medicinal chemistry, 2018-10, Vol.61 (20), p.9316-9334

2018

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Blockade of Protein Geranylgeranylation Inhibits Cdk2-Dependent p27Kip1 Phosphorylation on Thr187 and Accumulates p27Kip1 in the Nucleus: Implications for Breast Cancer Therapy

Molecular and Cellular Biology, 2009-04, Vol.29 (8), p.2254-2263

2009

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Abstract 2153: Kinome inhibitor screen identifies kinase inhibitors that inhibit selectively the survival of mutant K-Ras-dependent human cancer cells

Cancer research (Chicago, Ill.), 2015-08, Vol.75 (15_Supplement), p.2153-2153

2015

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The Akt activation inhibitor TCN-P inhibits Akt phosphorylation by binding to the PH domain of Akt and blocking its recruitment to the plasma membrane

Cell death and differentiation, 2010-11, Vol.17 (11), p.1795-1804

2010

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Targeting the BRD4-HOXB13 Coregulated Transcriptional Networks with Bromodomain-Kinase Inhibitors to Suppress Metastatic Castration-Resistant Prostate Cancer

Molecular cancer therapeutics, 2018-12, Vol.17 (12), p.2796-2810

2018

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The BH3 α-Helical Mimic BH3-M6 Disrupts Bcl-XL, Bcl-2, and MCL-1 Protein-Protein Interactions with Bax, Bak, Bad, or Bim and Induces Apoptosis in a Bax- and Bim-dependent Manner

The Journal of biological chemistry, 2011-03, Vol.286 (11), p.9382-9392

2011

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BET Bromodomain Inhibitors with One-Step Synthesis Discovered from Virtual Screen

Journal of medicinal chemistry, 2017-06, Vol.60 (12), p.4805-4817

2017

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Abstract 4522: Akt2 and acid ceramidase cooperate to induce malignant transformation

Cancer research (Chicago, Ill.), 2014-10, Vol.74 (19_Supplement), p.4522-4522

2014

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Single Molecule Dual JAK2-BET Inhibition As an MPN Therapeutic

Blood, 2015-12, Vol.126 (23), p.2826-2826

2015

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Targeting the BRD4-HOXB13 Co-regulated Transcriptional Networks with Bromodomain-Kinase Inhibitors to Suppress Metastatic Castration-Resistant Prostate Cancer

Molecular cancer therapeutics, 2018-09, Vol.17 (12), p.2796-2810

2018

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Potent dual BET bromodomain-kinase inhibitors as value added multi-targeted chemical probes and cancer therapeutics

Molecular cancer therapeutics, 2017-03, Vol.16 (6), p.1054-1067

2017

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Abstract 3643: Targeting the acetyl-lysine binding site of BRD4 with dual nanomolar BET-JAK2 inhibitors: A new anticancer therapeutic strategy

Cancer research (Chicago, Ill.), 2015-08, Vol.75 (15_Supplement), p.3643-3643

2015

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Correction to BET Bromodomain Inhibitors with One-Step Synthesis Discovered from Virtual Screen

Journal of medicinal chemistry, 2017-07, Vol.60 (14), p.6458-6458

2017

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Targeting protein prenylation for cancer therapy

Advances of small molecule targeting of kinases

Dual Targeting of WEE1 and PLK1 by AZD1775 Elicits Single Agent Cellular Anticancer Activity

Potent Dual BET Bromodomain-Kinase Inhibitors as Value-Added Multitargeted Chemical Probes and Cancer Therapeutics

Measurement of protein farnesylation and geranylgeranylation in vitro, in cultured cells and in biopsies, and the effects of prenyl transferase inhibitors

Discovery of a novel proteasome inhibitor selective for cancer cells over non-transformed cells

Marinopyrrole derivatives with sulfide spacers as selective disruptors of Mcl-1 binding to pro-apoptotic protein Bim

Protein phosphatase 1α-mediated stimulation of apoptosis is associated with dephosphorylation of the retinoblastoma protein

Bivalent BET Bromodomain Inhibitors Confer Increased Potency and Selectivity for BRDT via Protein Conformational Plasticity

Structural Basis of Wee Kinases Functionality and Inactivation by Diverse Small Molecule Inhibitors

Differential BET Bromodomain Inhibition by Dihydropteridinone and Pyrimidodiazepinone Kinase Inhibitors

Acetyl-lysine Binding Site of Bromodomain-Containing Protein 4 (BRD4) Interacts with Diverse Kinase Inhibitors

Molecular Basis for the N‑Terminal Bromodomain-and-Extra-Terminal-Family Selectivity of a Dual Kinase–Bromodomain Inhibitor

Blockade of Protein Geranylgeranylation Inhibits Cdk2-Dependent p27Kip1 Phosphorylation on Thr187 and Accumulates p27Kip1 in the Nucleus: Implications for Breast Cancer Therapy

Abstract 2153: Kinome inhibitor screen identifies kinase inhibitors that inhibit selectively the survival of mutant K-Ras-dependent human cancer cells

The Akt activation inhibitor TCN-P inhibits Akt phosphorylation by binding to the PH domain of Akt and blocking its recruitment to the plasma membrane

Targeting the BRD4-HOXB13 Coregulated Transcriptional Networks with Bromodomain-Kinase Inhibitors to Suppress Metastatic Castration-Resistant Prostate Cancer

The BH3 α-Helical Mimic BH3-M6 Disrupts Bcl-XL, Bcl-2, and MCL-1 Protein-Protein Interactions with Bax, Bak, Bad, or Bim and Induces Apoptosis in a Bax- and Bim-dependent Manner

BET Bromodomain Inhibitors with One-Step Synthesis Discovered from Virtual Screen

Abstract 4522: Akt2 and acid ceramidase cooperate to induce malignant transformation

Single Molecule Dual JAK2-BET Inhibition As an MPN Therapeutic

Targeting the BRD4-HOXB13 Co-regulated Transcriptional Networks with Bromodomain-Kinase Inhibitors to Suppress Metastatic Castration-Resistant Prostate Cancer

Potent dual BET bromodomain-kinase inhibitors as value added multi-targeted chemical probes and cancer therapeutics

Abstract 3643: Targeting the acetyl-lysine binding site of BRD4 with dual nanomolar BET-JAK2 inhibitors: A new anticancer therapeutic strategy

Correction to BET Bromodomain Inhibitors with One-Step Synthesis Discovered from Virtual Screen

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