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Exploiting Enzymatic Dynamic Reductive Kinetic Resolution (DYRKR) in Stereocontrolled Synthesis

Advanced synthesis & catalysis, 2015-05, Vol.357 (8), p.1619-1632

2015

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Mix-and-inject XFEL crystallography reveals gated conformational dynamics during enzyme catalysis

Proceedings of the National Academy of Sciences - PNAS, 2019-12, Vol.116 (51), p.25634-25640

2019

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Author Correction: Integrative network analyses of transcriptomics data reveal potential drug targets for acute radiation syndrome

Scientific reports, 2021-03, Vol.11 (1), p.7057-7057, Article 7057

2021

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General Linker Diversification Approach to Bivalent Ligand Assembly: Generation of an Array of Ligands for the Cation-Independent Mannose 6-Phosphate Receptor

Organic letters, 2017-08, Vol.19 (16), p.4267-4270

2017

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Human Serine Racemase: Key Residues/Active Site Motifs and Their Relation to Enzyme Function

Frontiers in molecular biosciences, 2019-03, Vol.6, p.8-8

2019

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Following an ISES Lead: The First Examples of Asymmetric Ni(0)-Mediated Allylic Amination

Organic letters, 2004-08, Vol.6 (16), p.2661-2664

2004

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Rapid Entry into Biologically Relevant α,α-Difluoroalkylphosphonates Bearing Allyl Protection–Deblocking under Ru(II)/(IV)-Catalysis

Organic letters, 2019-12, Vol.21 (24), p.9846-9851

2019

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Use of fluorinated functionality in enzyme inhibitor development: Mechanistic and analytical advantages

Journal of fluorine chemistry, 2008-09, Vol.129 (9), p.731-742

2008

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Rapid Enantioselective and Diastereoconvergent Hybrid Organic/Biocatalytic Entry into the Oseltamivir Core

Journal of organic chemistry, 2021-05, Vol.86 (9), p.6494-6503

2021

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“Zipped Synthesis” by Cross-Metathesis Provides a Cystathionine β‑Synthase Inhibitor that Attenuates Cellular H2S Levels and Reduces Neuronal Infarction in a Rat Ischemic Stroke Model

ACS central science, 2016-04, Vol.2 (4), p.242-252

2016

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"Cassette" In Situ Enzymatic Screening Identifies Complementary Chiral Scaffolds for Hydrolytic Kinetic Resolution Across a Range of Epoxides

Angewandte Chemie International Edition, 2007-01, Vol.46 (37), p.7010-7014

2007

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Combining a Clostridial Enzyme Exhibiting Unusual Active Site Plasticity with a Remarkably Facile Sigmatropic Rearrangement: Rapid, Stereocontrolled Entry into Densely Functionalized Fluorinated Phosphonates for Chemical Biology

Journal of the American Chemical Society, 2015-03, Vol.137 (10), p.3600-3609

2015

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Synthesis and Deployment of an Elusive Fluorovinyl Cation Equivalent: Access to Quaternary α‑(1′-Fluoro)vinyl Amino Acids as Potential PLP Enzyme Inactivators

Journal of the American Chemical Society, 2017-10, Vol.139 (40), p.14077-14089

2017

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Use of a Robust Dehydrogenase from an Archael Hyperthermophile in Asymmetric Catalysis−Dynamic Reductive Kinetic Resolution Entry into (S)-Profens

Journal of the American Chemical Society, 2010-05, Vol.132 (17), p.5930-5931

2010

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A Review of Radiation-Induced Alterations of Multi-Omic Profiles, Radiation Injury Biomarkers, and Countermeasures

Radiation research, 2023-01, Vol.199 (1), p.89

2023

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Biomacromolecule-Assisted Screening for Reaction Discovery and Catalyst Optimization

Chemical reviews, 2022-08, Vol.122 (16), p.13800-13880

2022

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Information-Rich, Dual-Function 13C/2H‑Isotopic Crosstalk NMR Assay for Human Serine Racemase (hSR) Provides a PLP-Enzyme “Partitioning Fingerprint” and Reveals Disparate Chemotypes for hSR Inhibition

Journal of the American Chemical Society, 2023-02, Vol.145 (5), p.3158-3174

2023

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Integrative network analyses of transcriptomics data reveal potential drug targets for acute radiation syndrome

Scientific reports, 2021-03, Vol.11 (1), p.5585-5585, Article 5585

2021

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Crystal Structures of Cystathionine β‑Synthase from Saccharomyces cerevisiae: One Enzymatic Step at a Time

Biochemistry (Easton), 2018-06, Vol.57 (22), p.3134-3145

2018

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Information-Rich, Dual-Function 13 C/ 2 H-Isotopic Crosstalk NMR Assay for Human Serine Racemase (hSR) Provides a PLP-Enzyme "Partitioning Fingerprint" and Reveals Disparate Chemotypes for hSR Inhibition

Journal of the American Chemical Society, 2023-02, Vol.145 (5), p.3158-3174

2023

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Human serine racemase structure/activity relationship studies provide mechanistic insight and point to position 84 as a hot spot for β-elimination function

The Journal of biological chemistry, 2017-08, Vol.292 (34), p.13986-14002

2017

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Enantioselective, Ketoreductase-Based Entry into Pharmaceutical Building Blocks: Ethanol as Tunable Nicotinamide Reductant

Organic letters, 2009-01, Vol.11 (2), p.305-308

2009

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Mono- and Bivalent Ligands Bearing Mannose 6-Phosphate (M6P) Surrogates: Targeting the M6P/Insulin-Like Growth Factor II Receptor

Organic letters, 2004-12, Vol.6 (26), p.4921-4924

2004

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Enzyme-Assisted Asymmetric Total Synthesis of (−)-Podophyllotoxin and (−)-Picropodophyllin

Journal of organic chemistry, 2000-02, Vol.65 (3), p.847-860

2000

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A set of phosphatase-inert “molecular rulers” to probe for bivalent mannose 6-phosphate ligand–receptor interactions

Bioorganic & medicinal chemistry, 2008-05, Vol.18 (10), p.3085-3089

2008

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Exploiting Enzymatic Dynamic Reductive Kinetic Resolution (DYRKR) in Stereocontrolled Synthesis

Mix-and-inject XFEL crystallography reveals gated conformational dynamics during enzyme catalysis

Author Correction: Integrative network analyses of transcriptomics data reveal potential drug targets for acute radiation syndrome

General Linker Diversification Approach to Bivalent Ligand Assembly: Generation of an Array of Ligands for the Cation-Independent Mannose 6-Phosphate Receptor

Human Serine Racemase: Key Residues/Active Site Motifs and Their Relation to Enzyme Function

Following an ISES Lead: The First Examples of Asymmetric Ni(0)-Mediated Allylic Amination

Rapid Entry into Biologically Relevant α,α-Difluoroalkylphosphonates Bearing Allyl Protection–Deblocking under Ru(II)/(IV)-Catalysis

Use of fluorinated functionality in enzyme inhibitor development: Mechanistic and analytical advantages

Rapid Enantioselective and Diastereoconvergent Hybrid Organic/Biocatalytic Entry into the Oseltamivir Core

“Zipped Synthesis” by Cross-Metathesis Provides a Cystathionine β‑Synthase Inhibitor that Attenuates Cellular H2S Levels and Reduces Neuronal Infarction in a Rat Ischemic Stroke Model

"Cassette" In Situ Enzymatic Screening Identifies Complementary Chiral Scaffolds for Hydrolytic Kinetic Resolution Across a Range of Epoxides

Combining a Clostridial Enzyme Exhibiting Unusual Active Site Plasticity with a Remarkably Facile Sigmatropic Rearrangement: Rapid, Stereocontrolled Entry into Densely Functionalized Fluorinated Phosphonates for Chemical Biology

Synthesis and Deployment of an Elusive Fluorovinyl Cation Equivalent: Access to Quaternary α‑(1′-Fluoro)vinyl Amino Acids as Potential PLP Enzyme Inactivators

Use of a Robust Dehydrogenase from an Archael Hyperthermophile in Asymmetric Catalysis−Dynamic Reductive Kinetic Resolution Entry into (S)-Profens

A Review of Radiation-Induced Alterations of Multi-Omic Profiles, Radiation Injury Biomarkers, and Countermeasures

Biomacromolecule-Assisted Screening for Reaction Discovery and Catalyst Optimization

Information-Rich, Dual-Function 13C/2H‑Isotopic Crosstalk NMR Assay for Human Serine Racemase (hSR) Provides a PLP-Enzyme “Partitioning Fingerprint” and Reveals Disparate Chemotypes for hSR Inhibition

Integrative network analyses of transcriptomics data reveal potential drug targets for acute radiation syndrome

Crystal Structures of Cystathionine β‑Synthase from Saccharomyces cerevisiae: One Enzymatic Step at a Time

Information-Rich, Dual-Function 13 C/ 2 H-Isotopic Crosstalk NMR Assay for Human Serine Racemase (hSR) Provides a PLP-Enzyme "Partitioning Fingerprint" and Reveals Disparate Chemotypes for hSR Inhibition

Human serine racemase structure/activity relationship studies provide mechanistic insight and point to position 84 as a hot spot for β-elimination function

Enantioselective, Ketoreductase-Based Entry into Pharmaceutical Building Blocks: Ethanol as Tunable Nicotinamide Reductant

Mono- and Bivalent Ligands Bearing Mannose 6-Phosphate (M6P) Surrogates: Targeting the M6P/Insulin-Like Growth Factor II Receptor

Enzyme-Assisted Asymmetric Total Synthesis of (−)-Podophyllotoxin and (−)-Picropodophyllin

A set of phosphatase-inert “molecular rulers” to probe for bivalent mannose 6-phosphate ligand–receptor interactions

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