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The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis

Nature communications, 2019-01, Vol.10 (1), p.6-6, Article 6

2019

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Systematic analysis of protein turnover in primary cells

Nature communications, 2018-02, Vol.9 (1), p.689-10, Article 689

2018

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Identifying drug targets in tissues and whole blood with thermal-shift profiling

Nature biotechnology, 2020-03, Vol.38 (3), p.303-308

2020

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Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes

Nature biotechnology, 2011-03, Vol.29 (3), p.255-265

2011

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Chemical Proteomics Reveals Ferrochelatase as a Common Off-target of Kinase Inhibitors

ACS chemical biology, 2016-05, Vol.11 (5), p.1245-1254

2016

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Network integration of thermal proteome profiling with multi-omics data decodes PARP inhibition

Molecular systems biology, 2024-04, Vol.20 (4), p.458-474

2024

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Author Correction: The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis

Nature communications, 2020-09, Vol.11 (1), p.4680-4680, Article 4680

2020

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Discovery of GSK8612, a Highly Selective and Potent TBK1 Inhibitor

ACS medicinal chemistry letters, 2019-05, Vol.10 (5), p.780-785

2019

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Picornavirus IRESes and the poly(A) tail jointly promote cap-independent translation in a mammalian cell-free system

RNA (Cambridge), 2000-12, Vol.6 (12), p.1781-1790, Article S1355838200001679

2000

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Enhancement of IRES-Mediated Translation of the c- myc and BiP mRNAs by the Poly(A) Tail Is Independent of Intact eIF4G and PABP

Molecular cell, 2004-09, Vol.15 (6), p.925-935

2004

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Drug Target Identification in Tissues by Thermal Proteome Profiling

Annual review of pharmacology and toxicology, 2022-01, Vol.62, p.465

2022

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Recent progress in small molecule TBK1 inhibitors: a patent review (2015- 2020)

Expert opinion on therapeutic patents, 2021-09, Vol.31 (9), p.785-794

2021

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Catalytic in vivo protein knockdown by small-molecule PROTACs

Nature chemical biology, 2015-08, Vol.11 (8), p.611

2015

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Multiplexed Proteome Dynamics Profiling Reveals Mechanisms Controlling Protein Homeostasis

Cell, 2018-03, Vol.173 (1), p.260-274.e25

2018

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A Modular Probe Strategy for Drug Localization, Target Identification and Target Occupancy Measurement on Single Cell Level

ACS chemical biology, 2016-09, Vol.11 (9), p.2541-2550

2016

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An integrated multiomic and quantitative label-free microscopy-based approach to study pro-fibrotic signalling in ex vivo human precision-cut lung slices

The European respiratory journal, 2021-07, Vol.58 (1), p.2000221

2021

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A selective inhibitor reveals PI3Kγ dependence of T(H)17 cell differentiation

Nature chemical biology, 2012-04, Vol.8 (6), p.576

2012

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Characterization of Apo‐Form Selective Inhibition of Indoleamine 2,3‐Dioxygenase

Chembiochem : a European journal of chemical biology, 2021-02, Vol.22 (3), p.516-522

2021

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amTCO, a new trans-cyclooctene derivative to study drug-target interactions in cells

Chemical communications (Cambridge, England), 2021-02, Vol.57 (14), p.1814-1817

2021

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A physical and functional map of the human TNF-α/NF-κB signal transduction pathway

Nature cell biology, 2004-02, Vol.6 (2), p.97-105

2004

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SAR studies around a series of triazolopyridines as potent and selective PI3Kγ inhibitors

Bioorganic & medicinal chemistry letters, 2012-08, Vol.22 (16), p.5257-5263

2012

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Optimization of Orally Bioavailable PI3Kδ Inhibitors and Identification of Vps34 as a Key Selectivity Target

Journal of medicinal chemistry, 2020-01, Vol.63 (2), p.638-655

2020

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Discovery of 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-(tert-butyl)pyridine-3-sulfonamide (CZC24758), as a potent, orally bioavailable and selective inhibitor of PI3K for the treatment of inflammatory disease

Bioorganic & medicinal chemistry letters, 2012-07, Vol.22 (14), p.4613-4618

2012

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Abstract 6647: Dostarlimab shows dose-dependent immune activation of the tumor microenvironment in a patient-derived NSCLC explant model similar to pembrolizumab

Cancer research (Chicago, Ill.), 2023-04, Vol.83 (7_Supplement), p.6647-6647

2023

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The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis

Systematic analysis of protein turnover in primary cells

Identifying drug targets in tissues and whole blood with thermal-shift profiling

Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes

Chemical Proteomics Reveals Ferrochelatase as a Common Off-target of Kinase Inhibitors

Network integration of thermal proteome profiling with multi-omics data decodes PARP inhibition

Author Correction: The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis

Discovery of GSK8612, a Highly Selective and Potent TBK1 Inhibitor

Picornavirus IRESes and the poly(A) tail jointly promote cap-independent translation in a mammalian cell-free system

Enhancement of IRES-Mediated Translation of the c- myc and BiP mRNAs by the Poly(A) Tail Is Independent of Intact eIF4G and PABP

Drug Target Identification in Tissues by Thermal Proteome Profiling

Recent progress in small molecule TBK1 inhibitors: a patent review (2015- 2020)

Design of amidobenzimidazole STING receptor agonists with systemic activity

Catalytic in vivo protein knockdown by small-molecule PROTACs

Multiplexed Proteome Dynamics Profiling Reveals Mechanisms Controlling Protein Homeostasis

A Modular Probe Strategy for Drug Localization, Target Identification and Target Occupancy Measurement on Single Cell Level

An integrated multiomic and quantitative label-free microscopy-based approach to study pro-fibrotic signalling in ex vivo human precision-cut lung slices

A selective inhibitor reveals PI3Kγ dependence of T(H)17 cell differentiation

Characterization of Apo‐Form Selective Inhibition of Indoleamine 2,3‐Dioxygenase

amTCO, a new trans-cyclooctene derivative to study drug-target interactions in cells

A physical and functional map of the human TNF-α/NF-κB signal transduction pathway

SAR studies around a series of triazolopyridines as potent and selective PI3Kγ inhibitors

Optimization of Orally Bioavailable PI3Kδ Inhibitors and Identification of Vps34 as a Key Selectivity Target

Discovery of 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-(tert-butyl)pyridine-3-sulfonamide (CZC24758), as a potent, orally bioavailable and selective inhibitor of PI3K for the treatment of inflammatory disease

Abstract 6647: Dostarlimab shows dose-dependent immune activation of the tumor microenvironment in a patient-derived NSCLC explant model similar to pembrolizumab

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