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In vitro and in vivo induction of fetal hemoglobin with a reversible and selective DNMT1 inhibitor

Haematologica (Roma), 2021-07, Vol.106 (7), p.1979-1987

2021

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Extended pharmacodynamic responses observed upon PROTAC-mediated degradation of RIPK2

Communications biology, 2020-03, Vol.3 (1), p.140, Article 140

2020

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The PROTACtable genome

Nature reviews. Drug discovery, 2021-10, Vol.20 (10), p.789-797

2021

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Selective CDK6 degradation mediated by cereblon, VHL, and novel IAP-recruiting PROTACs

Bioorganic & medicinal chemistry letters, 2020-05, Vol.30 (9), p.127106-127106, Article 127106

2020

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The therapeutic potential of PROTACs

Expert opinion on therapeutic patents, 2021, Vol.31 (1), p.1-24

2021

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Discovery and Characterisation of Highly Cooperative FAK‐Degrading PROTACs

Angewandte Chemie International Edition, 2021-10, Vol.60 (43), p.23327-23334

International ed. in English, 2021

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Stereochemistry of the Core Structure of the Mycolactones

Journal of the American Chemical Society, 2001-05, Vol.123 (21), p.5128-5129

2001

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Structural Insights into PROTAC-Mediated Degradation of Bcl-xL

ACS chemical biology, 2020-09, Vol.15 (9), p.2316-2323

2020

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Challenges and opportunities for in vivo PROTAC delivery

Future medicinal chemistry, 2022-01, Vol.14 (3), p.119-121

2022

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A hit deconstruction approach for the discovery of fetal hemoglobin inducers

Bioorganic & medicinal chemistry letters, 2018-12, Vol.28 (23-24), p.3676-3680

2018

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Total Synthesis of the Mycolactones

Organic letters, 2002-02, Vol.4 (4), p.647-650

2002

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Total synthesis of mycolactones A and B

Tetrahedron, 2007-06, Vol.63 (26), p.5739-5753

2007

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A Phenotypic Approach for the Identification of New Molecules for Targeted Protein Degradation Applications

SLAS discovery, 2021-08, Vol.26 (7), p.885-895

2021

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Discovery and Characterisation of Highly Cooperative FAK‐Degrading PROTACs

Angewandte Chemie, 2021-10, Vol.133 (43), p.23515-23522

2021

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P1536Does free thyroxine (fT4) predict risk of atherosclerotic cardiovascular disease (ASCVD)?

European heart journal, 2019-10, Vol.40 (Supplement_1)

2019

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Fragment-Based Discovery of 6‑Azaindazoles As Inhibitors of Bacterial DNA Ligase

ACS medicinal chemistry letters, 2013-12, Vol.4 (12), p.1208-1212

2013

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Design, Synthesis, and Evaluation of a Pyrrolinone−Peptide Hybrid Ligand for the Class II MHC Protein HLA-DR1

Journal of the American Chemical Society, 1998-12, Vol.120 (48), p.12704-12705

1998

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Design and Synthesis of a Competent Pyrrolinone−Peptide Hybrid Ligand for the Class II Major Histocompatibility Complex Protein HLA-DR1

Journal of the American Chemical Society, 1999-10, Vol.121 (40), p.9286-9298

1999

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Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia

Nature cancer, 2021-10, Vol.2 (10), p.1002-1017

2021

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The Crystal Structure of a Pyrrolinone−Peptide Hybrid Ligand Bound to the Human Class II MHC Protein HLA-DR1

Journal of the American Chemical Society, 2000-09, Vol.122 (35), p.8370-8375

2000

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An immunologically anomolous parathyroid hormone variant causing hyperparathyroidism

Clinical endocrinology (Oxford), 2001-09, Vol.55 (3), p.417-420

2001

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Population Pharmacokinetics of Didanosine in Patients with Human Immunodeficiency Virus Infection

The Journal of infectious diseases, 1996-01, Vol.173 (1), p.273-273

1996

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A second-generation synthesis of scalemic 3,5,5-trisubstituted pyrrolin-4-ones: Incorporation of functionalized amino acid side-chains

Tetrahedron letters, 1997-06, Vol.38 (22), p.3809-3812

1997

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Body image, eating disorders, and the relationship to adolescent media use

The Pediatric clinics of North America, 2012-06, Vol.59 (3), p.693-704

2012

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An immunologically anomolous parathyroid hormone variant causing hyperparathroidism

Clinical endocrinology (Oxford), 2001-09, Vol.55 (3), p.417

2001

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In vitro and in vivo induction of fetal hemoglobin with a reversible and selective DNMT1 inhibitor

Extended pharmacodynamic responses observed upon PROTAC-mediated degradation of RIPK2

The PROTACtable genome

Selective CDK6 degradation mediated by cereblon, VHL, and novel IAP-recruiting PROTACs

The therapeutic potential of PROTACs

Discovery and Characterisation of Highly Cooperative FAK‐Degrading PROTACs

Stereochemistry of the Core Structure of the Mycolactones

Structural Insights into PROTAC-Mediated Degradation of Bcl-xL

Challenges and opportunities for in vivo PROTAC delivery

A hit deconstruction approach for the discovery of fetal hemoglobin inducers

Total Synthesis of the Mycolactones

Total synthesis of mycolactones A and B

A Phenotypic Approach for the Identification of New Molecules for Targeted Protein Degradation Applications

Discovery and Characterisation of Highly Cooperative FAK‐Degrading PROTACs

P1536Does free thyroxine (fT4) predict risk of atherosclerotic cardiovascular disease (ASCVD)?

Fragment-Based Discovery of 6‑Azaindazoles As Inhibitors of Bacterial DNA Ligase

Design, Synthesis, and Evaluation of a Pyrrolinone−Peptide Hybrid Ligand for the Class II MHC Protein HLA-DR1

Design and Synthesis of a Competent Pyrrolinone−Peptide Hybrid Ligand for the Class II Major Histocompatibility Complex Protein HLA-DR1

Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia

The Crystal Structure of a Pyrrolinone−Peptide Hybrid Ligand Bound to the Human Class II MHC Protein HLA-DR1

An immunologically anomolous parathyroid hormone variant causing hyperparathyroidism

Population Pharmacokinetics of Didanosine in Patients with Human Immunodeficiency Virus Infection

A second-generation synthesis of scalemic 3,5,5-trisubstituted pyrrolin-4-ones: Incorporation of functionalized amino acid side-chains

Body image, eating disorders, and the relationship to adolescent media use

An immunologically anomolous parathyroid hormone variant causing hyperparathroidism

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