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Natural Products in Medicine: Transformational Outcome of Synthetic Chemistry

Journal of medicinal chemistry, 2014-11, Vol.57 (22), p.9292-9308

2014

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trans-1,2-Diaminocyclohexane Derivatives as Chiral Reagents, Scaffolds, and Ligands for Catalysis: Applications in Asymmetric Synthesis and Molecular Recognition

Chemical reviews, 1997-12, Vol.97 (8), p.3161-3196

1997

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Drug discovery in the next decade: innovation needed ASAP

Drug discovery today, 2011-09, Vol.16 (17), p.779-792

Bennani, Youssef L.

2011

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4-(2-[2-(2(R)-Methylpyrrolidin-1-yl)ethyl]benzofuran-5-yl)benzonitrile and Related 2-Aminoethylbenzofuran H3 Receptor Antagonists Potently Enhance Cognition and Attention

Journal of medicinal chemistry, 2005-01, Vol.48 (1), p.38-55

2005

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Drug hunters incorporated! Is there a formula?

Drug discovery today, 2015-01, Vol.20 (1), p.1-2

Bennani, Youssef L.

2015

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Structural Basis of Noscapine Activation for Tubulin Binding

Journal of medicinal chemistry, 2020-08, Vol.63 (15), p.8495-8501

2020

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Rapamycin and Less Immunosuppressive Analogs Are Toxic to Candida albicans and Cryptococcus neoformans via FKBP12-Dependent Inhibition of TOR

Antimicrobial Agents and Chemotherapy, 2001-11, Vol.45 (11), p.3162-3170

2001

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Drug discovery in the next decade: innovation needed ASAP

Drug discovery today, 2012-02, Vol.17, p.S31-S44

Bennani, Youssef L.

2012

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A new class of potent non-imidazole H3 antagonists: 2-aminoethylbenzofurans

Bioorganic & medicinal chemistry letters, 2004-02, Vol.14 (3), p.689-693

2004

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The identification and optimization of a N-hydroxy urea series of flap endonuclease 1 inhibitors

Bioorganic & medicinal chemistry letters, 2005-01, Vol.15 (2), p.277-281

2005

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Two novel and selective nonimidazole H3 receptor antagonists A-304121 and A-317920: II. In vivo behavioral and neurophysiological characterization

The Journal of pharmacology and experimental therapeutics, 2003-06, Vol.305 (3), p.897

2003

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Two novel and selective nonimidazole histamine H3 receptor antagonists A-304121 and A-317920: I. In vitro pharmacological effects

The Journal of pharmacology and experimental therapeutics, 2003-06, Vol.305 (3), p.887

2003

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Effects of histamine H3 receptor ligands GT-2331 and ciproxifan in a repeated acquisition avoidance response in the spontaneously hypertensive rat pup

Behavioural brain research, 2002-04, Vol.131 (1-2), p.151-161

2002

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Pharmacological and behavioral properties of A-349821, a selective and potent human histamine H3 receptor antagonist

Biochemical pharmacology, 2004-09, Vol.68 (5), p.933-945

2004

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Structure–activity relationships of arylbenzofuran H3 receptor antagonists

Bioorganic & medicinal chemistry letters, 2005-05, Vol.15 (10), p.2559-2563

2005

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The osmium-catalyzed asymmetric dihydroxylation: a new ligand class and a process improvement

Journal of organic chemistry, 1992-05, Vol.57 (10), p.2768-2771

1992

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Mtb PKNA/PKNB Dual Inhibition Provides Selectivity Advantages for Inhibitor Design To Minimize Host Kinase Interactions

ACS medicinal chemistry letters, 2017-12, Vol.8 (12), p.1224-1229

2017

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Design of a New Histamine H3 Receptor Antagonist Chemotype: (3aR,6aR)-5-Alkyl-1-aryl-octahydropyrrolo[3,4-b]pyrroles, Synthesis, and Structure−Activity Relationships

Journal of medicinal chemistry, 2009-08, Vol.52 (15), p.4640-4649

2009

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In Vitro and In Vivo Isotope Effects with Hepatitis C Protease Inhibitors: Enhanced Plasma Exposure of Deuterated Telaprevir versus Telaprevir in Rats

Journal of medicinal chemistry, 2009-12, Vol.52 (24), p.7993-8001

2009

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An Efficient Multigram Synthesis of the Potent Histamine H3 Antagonist GT-2331 and the Reassessment of the Absolute Configuration

Journal of organic chemistry, 2004-01, Vol.69 (1), p.192-194

2004

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Synthesis and SAR of aminoalkoxy-biaryl-4-carboxamides: Novel and selective histamine H3 receptor antagonists

Bioorganic & medicinal chemistry letters, 2003-04, Vol.13 (7), p.1325-1328

2003

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Tubulin Binding, Protein-Bound Conformation in Solution, and Antimitotic Cellular Profiling of Noscapine and Its Derivatives

Journal of medicinal chemistry, 2012-03, Vol.55 (5), p.1920-1925

2012

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Discovery of Novel, Orally Bioavailable β‑Amino Acid Azaindole Inhibitors of Influenza PB2

ACS medicinal chemistry letters, 2017-02, Vol.8 (2), p.256-260

2017

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A novel chemotype of kinase inhibitors: Discovery of 3,4-ring fused 7-azaindoles and deazapurines as potent JAK2 inhibitors

Bioorganic & medicinal chemistry letters, 2010, Vol.20 (1), p.153-156

2010

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Natural Products in Medicine: Transformational Outcome of Synthetic Chemistry

trans-1,2-Diaminocyclohexane Derivatives as Chiral Reagents, Scaffolds, and Ligands for Catalysis: Applications in Asymmetric Synthesis and Molecular Recognition

Drug discovery in the next decade: innovation needed ASAP

4-(2-[2-(2(R)-Methylpyrrolidin-1-yl)ethyl]benzofuran-5-yl)benzonitrile and Related 2-Aminoethylbenzofuran H3 Receptor Antagonists Potently Enhance Cognition and Attention

Drug hunters incorporated! Is there a formula?

Structural Basis of Noscapine Activation for Tubulin Binding

Rapamycin and Less Immunosuppressive Analogs Are Toxic to Candida albicans and Cryptococcus neoformans via FKBP12-Dependent Inhibition of TOR

Drug discovery in the next decade: innovation needed ASAP

A new class of potent non-imidazole H3 antagonists: 2-aminoethylbenzofurans

The identification and optimization of a N-hydroxy urea series of flap endonuclease 1 inhibitors

Two novel and selective nonimidazole H3 receptor antagonists A-304121 and A-317920: II. In vivo behavioral and neurophysiological characterization

Two novel and selective nonimidazole histamine H3 receptor antagonists A-304121 and A-317920: I. In vitro pharmacological effects

Effects of histamine H3 receptor ligands GT-2331 and ciproxifan in a repeated acquisition avoidance response in the spontaneously hypertensive rat pup

Pharmacological and behavioral properties of A-349821, a selective and potent human histamine H3 receptor antagonist

Structure–activity relationships of arylbenzofuran H3 receptor antagonists

The osmium-catalyzed asymmetric dihydroxylation: a new ligand class and a process improvement

Mtb PKNA/PKNB Dual Inhibition Provides Selectivity Advantages for Inhibitor Design To Minimize Host Kinase Interactions

Design of a New Histamine H3 Receptor Antagonist Chemotype: (3aR,6aR)-5-Alkyl-1-aryl-octahydropyrrolo[3,4-b]pyrroles, Synthesis, and Structure−Activity Relationships

In Vitro and In Vivo Isotope Effects with Hepatitis C Protease Inhibitors: Enhanced Plasma Exposure of Deuterated Telaprevir versus Telaprevir in Rats

An Efficient Multigram Synthesis of the Potent Histamine H3 Antagonist GT-2331 and the Reassessment of the Absolute Configuration

Synthesis and SAR of aminoalkoxy-biaryl-4-carboxamides: Novel and selective histamine H3 receptor antagonists

Pharmacological properties of ABT-239 [4-(2-{2-[(2R)-2-Methylpyrrolidinyl]ethyl}-benzofuran-5-yl)benzonitrile]: II. Neurophysiological characterization and broad preclinical efficacy in cognition and schizophrenia of a potent and selective histamine H3 receptor antagonist

Tubulin Binding, Protein-Bound Conformation in Solution, and Antimitotic Cellular Profiling of Noscapine and Its Derivatives

Discovery of Novel, Orally Bioavailable β‑Amino Acid Azaindole Inhibitors of Influenza PB2

A novel chemotype of kinase inhibitors: Discovery of 3,4-ring fused 7-azaindoles and deazapurines as potent JAK2 inhibitors

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