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A Subset of Human Bromodomains Recognizes Butyryllysine and Crotonyllysine Histone Peptide Modifications

Structure (London), 2015-10, Vol.23 (10), p.1801-1814

2015

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Identification of (R)‑N‑((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)‑1H‑indole-3-carboxamide (CPI-1205), a Potent and Selective Inhibitor of Histone Methyltransferase EZH2, Suitable for Phase I Clinical Trials for B‑Cell Lymphomas

Journal of medicinal chemistry, 2016-11, Vol.59 (21), p.9928-9941

2016

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Discovery of 1H‑Pyrazol-3(2H)‑ones as Potent and Selective Inhibitors of Protein Kinase R‑like Endoplasmic Reticulum Kinase (PERK)

Journal of medicinal chemistry, 2015-02, Vol.58 (3), p.1426-1441

2015

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Structure-Based Design of Novel Class II c-Met Inhibitors: 2. SAR and Kinase Selectivity Profiles of the Pyrazolone Series

Journal of medicinal chemistry, 2012-03, Vol.55 (5), p.1868-1897

2012

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c-Met Inhibitors with Novel Binding Mode Show Activity against Several Hereditary Papillary Renal Cell Carcinoma-related Mutations

The Journal of biological chemistry, 2008-02, Vol.283 (5), p.2675-2683

2008

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Discovery and Optimization of Triazolopyridazines as Potent and Selective Inhibitors of the c-Met Kinase

Journal of medicinal chemistry, 2008-05, Vol.51 (10), p.2879-2882

2008

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Discovery of Potent and Selective 8‑Fluorotriazolopyridine c‑Met Inhibitors

Journal of medicinal chemistry, 2015-03, Vol.58 (5), p.2417-2430

2015

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c-Met inhibitors with different binding modes: Two is better than one

Cell cycle (Georgetown, Tex.), 2008-05, Vol.7 (9), p.1157-1160

2008

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GNE-064: A Potent, Selective, and Orally Bioavailable Chemical Probe for the Bromodomains of SMARCA2 and SMARCA4 and the Fifth Bromodomain of PBRM1

Journal of medicinal chemistry, 2022-08, Vol.65 (16), p.11177-11186

2022

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From concept to reality: the long road to c-Met and RON receptor tyrosine kinase inhibitors for the treatment of cancer

Anti-cancer agents in medicinal chemistry, 2009-02, Vol.9 (2), p.221-229

2009

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Structure-Based Design of Novel Class II c-Met Inhibitors: 1. Identification of Pyrazolone-Based Derivatives

Journal of medicinal chemistry, 2012-03, Vol.55 (5), p.1858-1867

2012

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Regulatory T Cell Modulation by CBP/EP300 Bromodomain Inhibition

The Journal of biological chemistry, 2016-06, Vol.291 (25), p.13014-13027

2016

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Identification of potent, selective KDM5 inhibitors

Bioorganic & medicinal chemistry letters, 2016-09, Vol.26 (17), p.4350-4354

2016

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Design and Synthesis of Styrenylcyclopropylamine LSD1 Inhibitors

ACS medicinal chemistry letters, 2020-06, Vol.11 (6), p.1213-1220

2020

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Discovery of a Potent, Selective, and Orally Bioavailable c-Met Inhibitor: 1-(2-Hydroxy-2-methylpropyl)-N-(5-(7-methoxyquinolin-4-yloxy)pyridin-2-yl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide (AMG 458)

Journal of medicinal chemistry, 2008-07, Vol.51 (13), p.3688-3691

2008

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DNA unwinding produced by site-specific intrastrand cross-links of the antitumor drug cis-diamminedichloroplatinum(II)

Biochemistry (Easton), 1991-08, Vol.30 (32), p.8026-8035

1991

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Design, Synthesis, and Biological Evaluation of Potent c-Met Inhibitors

Journal of medicinal chemistry, 2008-09, Vol.51 (18), p.5766-5779

2008

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Application of synthetic siderite (FeCO3) to the soil is capable of alleviating iron chlorosis in olive trees

Scientia horticulturae, 2012-05, Vol.138, p.17-23

2012

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The Discovery of VX-745: A Novel and Selective p38α Kinase Inhibitor

ACS medicinal chemistry letters, 2011-10, Vol.2 (10), p.758-763

2011

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Discovery and optimization of potent and selective triazolopyridazine series of c-Met inhibitors

Bioorganic & medicinal chemistry letters, 2009-11, Vol.19 (22), p.6307-6312

2009

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Correction to Discovery of Potent and Selective 8‑Fluorotriazolopyridine c‑Met Inhibitors

Journal of medicinal chemistry, 2015-05, Vol.58 (9), p.4087-4087

2015

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Discovery and optimization of a potent and selective triazolopyridinone series of c-Met inhibitors

Bioorganic & medicinal chemistry letters, 2012-06, Vol.22 (12), p.4089-4093

2012

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Bending studies of DNA site-specifically modified by cisplatin, trans-diamminedichloroplatinum(II) and cis-[Pt(NH 3) 2 ( N3-cytosine) Cl]

Biophysical chemistry, 1990-04, Vol.35 (2), p.179-188

1990

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Crystal structure of the RAG1 dimerization domain reveals multiple zinc-binding motifs including a novel zinc binuclear cluster

Nature structural biology, 1997-07, Vol.4 (7), p.586-591

1997

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A Subset of Human Bromodomains Recognizes Butyryllysine and Crotonyllysine Histone Peptide Modifications

Discovery of 1H‑Pyrazol-3(2H)‑ones as Potent and Selective Inhibitors of Protein Kinase R‑like Endoplasmic Reticulum Kinase (PERK)

Structure-Based Design of Novel Class II c-Met Inhibitors: 2. SAR and Kinase Selectivity Profiles of the Pyrazolone Series

c-Met Inhibitors with Novel Binding Mode Show Activity against Several Hereditary Papillary Renal Cell Carcinoma-related Mutations

Discovery and Optimization of Triazolopyridazines as Potent and Selective Inhibitors of the c-Met Kinase

Discovery of Potent and Selective 8‑Fluorotriazolopyridine c‑Met Inhibitors

c-Met inhibitors with different binding modes: Two is better than one

GNE-064: A Potent, Selective, and Orally Bioavailable Chemical Probe for the Bromodomains of SMARCA2 and SMARCA4 and the Fifth Bromodomain of PBRM1

From concept to reality: the long road to c-Met and RON receptor tyrosine kinase inhibitors for the treatment of cancer

Structure-Based Design of Novel Class II c-Met Inhibitors: 1. Identification of Pyrazolone-Based Derivatives

Regulatory T Cell Modulation by CBP/EP300 Bromodomain Inhibition

Identification of potent, selective KDM5 inhibitors

Discovery of (R)‑6-(1-(8-Fluoro-6-(1-methyl‑1H‑pyrazol-4-yl)-[1,2,4]triazolo[4,3‑a]pyridin-3-yl)ethyl)-3-(2-methoxyethoxy)-1,6-naphthyridin-5(6H)‑one (AMG 337), a Potent and Selective Inhibitor of MET with High Unbound Target Coverage and Robust In Vivo Antitumor Activity

Design and Synthesis of Styrenylcyclopropylamine LSD1 Inhibitors

Discovery of a Potent, Selective, and Orally Bioavailable c-Met Inhibitor: 1-(2-Hydroxy-2-methylpropyl)-N-(5-(7-methoxyquinolin-4-yloxy)pyridin-2-yl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide (AMG 458)

DNA unwinding produced by site-specific intrastrand cross-links of the antitumor drug cis-diamminedichloroplatinum(II)

Design, Synthesis, and Biological Evaluation of Potent c-Met Inhibitors

Application of synthetic siderite (FeCO3) to the soil is capable of alleviating iron chlorosis in olive trees

The Discovery of VX-745: A Novel and Selective p38α Kinase Inhibitor

Discovery and optimization of potent and selective triazolopyridazine series of c-Met inhibitors

Correction to Discovery of Potent and Selective 8‑Fluorotriazolopyridine c‑Met Inhibitors

Discovery and optimization of a potent and selective triazolopyridinone series of c-Met inhibitors

Bending studies of DNA site-specifically modified by cisplatin, trans-diamminedichloroplatinum(II) and cis-[Pt(NH 3) 2 ( N3-cytosine) Cl]

Crystal structure of the RAG1 dimerization domain reveals multiple zinc-binding motifs including a novel zinc binuclear cluster

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