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Inhibition of the late sodium current as a potential cardioprotective principle: effects of the late sodium current inhibitor ranolazine

Heart (British Cardiac Society), 2006-07, Vol.92 (suppl 4), p.iv6-iv14

2006

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The novel CaMKII inhibitor GS-680 reduces diastolic SR Ca leak and prevents CaMKII-dependent pro-arrhythmic activity

Journal of molecular and cellular cardiology, 2018-05, Vol.118, p.159-168

2018

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Mechanisms of ranolazine's dual protection against atrial and ventricular fibrillation

Europace (London, England), 2013-03, Vol.15 (3), p.317-324

2013

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Inhibition of late sodium current to reduce electrical and mechanical dysfunction of ischaemic myocardium

British journal of pharmacology, 2008-03, Vol.153 (6), p.1128-1132

2008

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Augmentation of late sodium current unmasks the proarrhythmic effects of amiodarone

Cardiovascular research, 2008-02, Vol.77 (3), p.481-488

2008

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Effect of ranolazine on glycaemic control in patients with type 2 diabetes treated with either glimepiride or metformin

Diabetes, obesity & metabolism, 2016-05, Vol.18 (5), p.463-474

2016

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Increased Nav 1.5 channel late current underlies prolongation of action potential duration of ventricular myocytes from aged guinea pigs

Heart rhythm, 2013-11, Vol.10 (11), p.1748-1749

2013

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Ranolazine: Ion‐channel‐blocking actions and in vivo electrophysiological effects

British journal of pharmacology, 2004-08, Vol.142 (8), p.1300-1308

2004

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Robust anti‐arrhythmic efficacy of verapamil and flunarizine against dofetilide‐induced TdP arrhythmias is based upon a shared and a different mode of action

British journal of pharmacology, 2010-09, Vol.161 (1), p.162-175

2010

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Paradoxical Prolongation of QT Interval During Exercise in Patients with Hypertrophic Cardiomyopathy

Heart rhythm, 2013-11, Vol.10 (11), p.1752-1752

2013

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Late Sodium Current Is an Intrinsic Regulator of Cardiac Repolarization—A Quantitative Assessment

Heart rhythm, 2012-11, Vol.9 (11), p.1909-1909

2012

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Fast delivery of flecainide via the pulmonary (bolus) or intravenous (rapid infusion) routes reduces atrial fibrillation conversion dose and minimizes negative inotropic burden

European heart journal, 2020-11, Vol.41 (Supplement_2)

2020

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Selective Inhibition of Endogenous Late Na+ Current Stabilizes Cardiac Repolarization and Prevents Arrhythmogenicity

Heart rhythm, 2013-11, Vol.10 (11), p.1744-1744

2013

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Ionic basis of the electrophysiological actions of adenosine on cardiomyocytes

The FASEB journal, 1995-03, Vol.9 (5), p.359-365

1995

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Ranolazine Causes Atrial-Selective Electrophysiological Effects and Suppresses the Induction of Atrial Fibrillation in a Canine Model of Heart Failure

Heart rhythm, 2012-11, Vol.9 (11), p.1914-1914

2012

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Ranolazine and Dofetilide Effectively Suppress Acute Atrial Fibrillation in Isolated Sheep Hearts

Heart rhythm, 2013-11, Vol.10 (11), p.1746-1746

2013

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P3810Hysteresis between pharmacokinetics and changes in QRS complex duration following flecainide administered via oral inhalation or IV infusion

European heart journal, 2018-08, Vol.39 (suppl_1)

2018

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Comparison of the antilipolytic effects of an A₁ adenosine receptor partial agonist in normal and diabetic rats

Diabetes, obesity & metabolism, 2009-02, Vol.11 (2), p.95-101

2009

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GS967, By Blocking the Late Sodium Current (INaL ), Has Strong Action Potential–Stabilizing Properties in Isolated Remodeled Ventricular Canine Cells

Heart rhythm, 2013-11, Vol.10 (11), p.1742-1742

2013

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Inhibition of late (sustained/ persistent) sodium current: a potential drug target to reduce intracellular sodium-dependent calcium overload and its detrimental effects on cardiomyocyte function

European heart journal supplements, 2004-12, Vol.6, p.I3-I7

2004

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Role of Increased Ca2+ /Calmodulin-Dependent Protein Kinase II and Late Na+ Current in the Diastolic Dysfunction and Electrical Instability of Human Hypertrophic Cardiomyopathy

Heart rhythm, 2011-11, Vol.8 (11), p.1821-1821

2011

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Block of peripheral nerve sodium channels by Ranolazine

The journal of pain, 2009-04, Vol.10 (4), p.S33-S33

2009

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Effects of dipyridamole on coronary collateralization and myocardial perfusion in patients with ischaemic cardiomyopathy

European heart journal, 2001-07, Vol.22 (14), p.1205-1213

2001

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Effects of Ranolazine on Paroxysmal and Persistent Atrial Fibrillation in Isolated Sheep Hearts

Heart rhythm, 2012-11, Vol.9 (11), p.1915-1915

2012

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Cardiac electrophysiology of adenosine : basic and clinical concepts

Circulation (New York, N.Y.), 1991-05, Vol.83 (5), p.1499-1509

1991

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Inhibition of the late sodium current as a potential cardioprotective principle: effects of the late sodium current inhibitor ranolazine

The novel CaMKII inhibitor GS-680 reduces diastolic SR Ca leak and prevents CaMKII-dependent pro-arrhythmic activity

Mechanisms of ranolazine's dual protection against atrial and ventricular fibrillation

Inhibition of late sodium current to reduce electrical and mechanical dysfunction of ischaemic myocardium

Augmentation of late sodium current unmasks the proarrhythmic effects of amiodarone

Effect of ranolazine on glycaemic control in patients with type 2 diabetes treated with either glimepiride or metformin

Increased Nav 1.5 channel late current underlies prolongation of action potential duration of ventricular myocytes from aged guinea pigs

Ranolazine: Ion‐channel‐blocking actions and in vivo electrophysiological effects

Robust anti‐arrhythmic efficacy of verapamil and flunarizine against dofetilide‐induced TdP arrhythmias is based upon a shared and a different mode of action

Paradoxical Prolongation of QT Interval During Exercise in Patients with Hypertrophic Cardiomyopathy

Late Sodium Current Is an Intrinsic Regulator of Cardiac Repolarization—A Quantitative Assessment

Fast delivery of flecainide via the pulmonary (bolus) or intravenous (rapid infusion) routes reduces atrial fibrillation conversion dose and minimizes negative inotropic burden

Selective Inhibition of Endogenous Late Na+ Current Stabilizes Cardiac Repolarization and Prevents Arrhythmogenicity

Ionic basis of the electrophysiological actions of adenosine on cardiomyocytes

Ranolazine Causes Atrial-Selective Electrophysiological Effects and Suppresses the Induction of Atrial Fibrillation in a Canine Model of Heart Failure

Ranolazine and Dofetilide Effectively Suppress Acute Atrial Fibrillation in Isolated Sheep Hearts

P3810Hysteresis between pharmacokinetics and changes in QRS complex duration following flecainide administered via oral inhalation or IV infusion

Comparison of the antilipolytic effects of an A₁ adenosine receptor partial agonist in normal and diabetic rats

GS967, By Blocking the Late Sodium Current (INaL ), Has Strong Action Potential–Stabilizing Properties in Isolated Remodeled Ventricular Canine Cells

Inhibition of late (sustained/ persistent) sodium current: a potential drug target to reduce intracellular sodium-dependent calcium overload and its detrimental effects on cardiomyocyte function

Role of Increased Ca2+ /Calmodulin-Dependent Protein Kinase II and Late Na+ Current in the Diastolic Dysfunction and Electrical Instability of Human Hypertrophic Cardiomyopathy

Block of peripheral nerve sodium channels by Ranolazine

Effects of dipyridamole on coronary collateralization and myocardial perfusion in patients with ischaemic cardiomyopathy

Effects of Ranolazine on Paroxysmal and Persistent Atrial Fibrillation in Isolated Sheep Hearts

Cardiac electrophysiology of adenosine : basic and clinical concepts

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