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Discovery of a Potent and Orally Active Hedgehog Pathway Antagonist (IPI-926)

Journal of medicinal chemistry, 2009-07, Vol.52 (14), p.4400-4418

2009

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Semisynthetic Cyclopamine Analogues as Potent and Orally Bioavailable Hedgehog Pathway Antagonists

Journal of medicinal chemistry, 2008-11, Vol.51 (21), p.6646-6649

2008

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Discovery of ecopladib, an indole inhibitor of cytosolic phospholipase A2α

Journal of medicinal chemistry, 2007-03, Vol.50 (6), p.1380-1400

2007

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Discovery of Ecopladib, an Indole Inhibitor of Cytosolic Phospholipase Α2α

Journal of medicinal chemistry, 2007-03, Vol.50 (6), p.1380-1400

2007

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Inhibition of Cytosolic Phospholipase A2α: Hit to Lead Optimization

Journal of medicinal chemistry, 2006-01, Vol.49 (1), p.135-158

2006

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A Novel and Efficient Synthesis of a Highly Active Analogue of clasto-Lactacystin β-Lactone

Journal of the American Chemical Society, 1999-11, Vol.121 (43), p.9967-9976

1999

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Benzenesulfonamide indole inhibitors of cytosolic phospholipase A2α : Optimization of in vitro potency and rat pharmacokinetics for oral efficacy

Bioorganic & medicinal chemistry, 2008-02, Vol.16 (3), p.1345-1358

2008

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Thermodynamic characterization of cytosolic phospholipase A2 alpha inhibitors

Analytical biochemistry, 2008-12, Vol.383 (2), p.217-225

2008

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Novel non-nucleoside inhibitors of HIV-1 reverse transcriptase. 2. Tricyclic pyridobenzoxazepinones and dibenzoxazepinones

Journal of medicinal chemistry, 1992-05, Vol.35 (10), p.1887-1897

1992

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Thermodynamic characterization of cytosolic phospholipase A 2 alpha inhibitors

Analytical biochemistry, 2008, Vol.383 (2), p.217-225

2008

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Benzenesulfonamide indole inhibitors of cytosolic phospholipase A 2α: Optimization of in vitro potency and rat pharmacokinetics for oral efficacy

Bioorganic & medicinal chemistry, 2008, Vol.16 (3), p.1345-1358

2008

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Discovery of Ecopladib, an indole inhibitor of cytosolic phospholipase A2alpha

Journal of medicinal chemistry, 2007-03, Vol.50 (6), p.1380-1400

2007

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Discovery of Ecopladib, an Indole Inhibitor of Cytosolic Phospholipase Α 2 α

Journal of medicinal chemistry, 2007-03, Vol.50 (6), p.1380-1400

2007

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Inhibition of cytosolic phospholipase A2alpha: hit to lead optimization

Journal of medicinal chemistry, 2006-01, Vol.49 (1), p.135-158

2006

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Inhibition of Cytosolic Phospholipase A 2 α: Hit to Lead Optimization

Journal of medicinal chemistry, 2006-01, Vol.49 (1), p.135-158

2006

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Novel non-nucleoside inhibitors of HIV-1 reverse transcriptase. 1. Tricyclic pyridobenzo- and dipyridodiazepinones

Journal of medicinal chemistry, 1991-07, Vol.34 (7), p.2231-2241

1991

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Benzenesulfonamide indole inhibitors of cytosolic phospholipase A2alpha: optimization of in vitro potency and rat pharmacokinetics for oral efficacy

Bioorganic & medicinal chemistry, 2008-02, Vol.16 (3), p.1345

2008

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A general stereocontrolled synthesis of cis-2,3 disubstituted pyrrolidines and piperidines

Tetrahedron letters, 1993-09, Vol.34 (39), p.6205-6208

1993

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ChemInform Abstract: A Novel and Efficient Synthesis of a Highly Active Analogue of clasto-Lactacystin β-Lactone

ChemInform, 2000-02, Vol.31 (6), p.no-no

2000

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Potent and selective inhibitors of the proteasome: Dipeptidyl boronic acids

Bioorganic & medicinal chemistry letters, 1998-02, Vol.8 (4), p.333-338

1998

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Differential induction of c-Jun and Fos-like proteins in rat hippocampus and dorsal striatum after training in two water maze tasks

Neurobiology of learning and memory, 2005-09, Vol.84 (2), p.75-84

2005

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Discovery of a Potent and Orally Active Hedgehog Pathway Antagonist (IPI-926)

Small molecule inhibition of group I p21-activated kinases in breast cancer induces apoptosis and potentiates the activity of microtubule stabilizing agents

Semisynthetic Cyclopamine Analogues as Potent and Orally Bioavailable Hedgehog Pathway Antagonists

Indole Cytosolic Phospholipase A2 α Inhibitors: Discovery and in Vitro and in Vivo Characterization of 4-{3-[5-Chloro-2-(2-{[(3,4-dichlorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylmethyl)-1H-indol-3-yl]propyl}benzoic Acid, Efipladib

Discovery of ecopladib, an indole inhibitor of cytosolic phospholipase A2α

Discovery of Ecopladib, an Indole Inhibitor of Cytosolic Phospholipase Α2α

Inhibition of Cytosolic Phospholipase A2α: Hit to Lead Optimization

A Novel and Efficient Synthesis of a Highly Active Analogue of clasto-Lactacystin β-Lactone

Benzenesulfonamide indole inhibitors of cytosolic phospholipase A2α : Optimization of in vitro potency and rat pharmacokinetics for oral efficacy

Thermodynamic characterization of cytosolic phospholipase A2 alpha inhibitors

Novel non-nucleoside inhibitors of HIV-1 reverse transcriptase. 2. Tricyclic pyridobenzoxazepinones and dibenzoxazepinones

Thermodynamic characterization of cytosolic phospholipase A 2 alpha inhibitors

Indole Cytosolic Phospholipase A 2 α Inhibitors: Discovery and in Vitro and in Vivo Characterization of 4-{3-[5-Chloro-2-(2-{[(3,4-dichlorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylmethyl)-1 H -indol-3-yl]propyl}benzoic Acid, Efipladib

Benzenesulfonamide indole inhibitors of cytosolic phospholipase A 2α: Optimization of in vitro potency and rat pharmacokinetics for oral efficacy

Discovery of Ecopladib, an indole inhibitor of cytosolic phospholipase A2alpha

Indole Cytosolic Phospholipase A2 α Inhibitors : Discovery and in Vitro and in Vivo Characterization of 4-{3-[5-Chloro-2-(2-{[(3,4-dichlorobenzyl)sulfonyl]amino}ethyl)-l-(diphenylmethyl)-1H-indol-3-yl]propyl}benzoic Acid, Efipladib

Discovery of Ecopladib, an Indole Inhibitor of Cytosolic Phospholipase Α 2 α

Inhibition of cytosolic phospholipase A2alpha: hit to lead optimization

Inhibition of Cytosolic Phospholipase A 2 α: Hit to Lead Optimization

Novel non-nucleoside inhibitors of HIV-1 reverse transcriptase. 1. Tricyclic pyridobenzo- and dipyridodiazepinones

Benzenesulfonamide indole inhibitors of cytosolic phospholipase A2alpha: optimization of in vitro potency and rat pharmacokinetics for oral efficacy

A general stereocontrolled synthesis of cis-2,3 disubstituted pyrrolidines and piperidines

ChemInform Abstract: A Novel and Efficient Synthesis of a Highly Active Analogue of clasto-Lactacystin β-Lactone

Potent and selective inhibitors of the proteasome: Dipeptidyl boronic acids

Differential induction of c-Jun and Fos-like proteins in rat hippocampus and dorsal striatum after training in two water maze tasks

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