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Mutations in hereditary phosphoglucomutase 1 deficiency map to key regions of enzyme structure and function

Journal of inherited metabolic disease, 2015-03, Vol.38 (2), p.243-256

Beamer, Lesa J.

2015

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Discovery of a small-molecule inhibitor and cellular probe of Keap1–Nrf2 protein–protein interaction

Bioorganic & medicinal chemistry letters, 2013-05, Vol.23 (10), p.3039-3043

2013

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Sequence-structure relationships, expression profiles, and disease-associated mutations in the paralogs of phosphoglucomutase 1

PloS one, 2017-08, Vol.12 (8), p.e0183563-e0183563

2017

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Enzyme dysfunction at atomic resolution: Disease-associated variants of human phosphoglucomutase-1

Biochimie, 2021-04, Vol.183, p.44-48

Beamer, Lesa J.

2021

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Optimization of fluorescently labeled Nrf2 peptide probes and the development of a fluorescence polarization assay for the discovery of inhibitors of Keap1-Nrf2 interaction

Journal of biomolecular screening, 2012-04, Vol.17 (4), p.435-447

2012

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Phosphorylation in the Catalytic Cleft Stabilizes and Attracts Domains of a Phosphohexomutase

Biophysical journal, 2015-01, Vol.108 (2), p.325-337

2015

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Crystal Structure of the Kelch Domain of Human Keap1

The Journal of biological chemistry, 2004-12, Vol.279 (52), p.54750-54758

2004

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Crystal Structure of Bacillus anthracis Phosphoglucosamine Mutase, an Enzyme in the Peptidoglycan Biosynthetic Pathway

Journal of Bacteriology, 2011-08, Vol.193 (16), p.4081-4087

2011

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A coevolutionary residue network at the site of a functionally important conformational change in a phosphohexomutase enzyme family

PloS one, 2012-06, Vol.7 (6), p.e38114

2012

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Multiple Ligand-Bound States of a Phosphohexomutase Revealed by Principal Component Analysis of NMR Peak Shifts

Scientific reports, 2017-07, Vol.7 (1), p.5343-11, Article 5343

2017

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A Hotspot for Disease-Associated Variants of Human PGM1 Is Associated with Impaired Ligand Binding and Loop Dynamics

Structure (London), 2018-10, Vol.26 (10), p.1337-1345.e3

2018

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Data on the phosphorylation state of the catalytic serine of enzymes in the α-D-phosphohexomutase superfamily

Data in brief, 2017-02, Vol.10 (C), p.398-405

2017

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Synthesis, Derivatization, and Structural Analysis of Phosphorylated Mono‑, Di‑, and Trifluorinated d‑Gluco-heptuloses by Glucokinase: Tunable Phosphoglucomutase Inhibition

ACS omega, 2019-04, Vol.4 (4), p.7029-7037

2019

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Structural and dynamical description of the enzymatic reaction of a phosphohexomutase

Structural dynamics (Melville, N.Y.), 2019-03, Vol.6 (2), p.024703-024703

2019

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Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling

The EMBO journal, 2006-08, Vol.25 (15), p.3605-3617

2006

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Structural and functional analysis of two SHMT8 variants associated with soybean cyst nematode resistance

The FEBS journal, 2024-01, Vol.291 (2), p.323-337

2024

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Compromised Catalysis and Potential Folding Defects in in Vitro Studies of Missense Mutants Associated with Hereditary Phosphoglucomutase 1 Deficiency

The Journal of biological chemistry, 2014-11, Vol.289 (46), p.32010-32019

2014

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Crystal Structure of Human BPI and Two Bound Phospholipids at 2.4 Angstrom Resolution

Science (American Association for the Advancement of Science), 1997-06, Vol.276 (5320), p.1861-1864

1997

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Biology, Mechanism, and Structure of Enzymes in the α-d-Phosphohexomutase Superfamily

Advances in protein chemistry and structural biology, 2017, Vol.109, p.265

2017

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Impaired folate binding of serine hydroxymethyltransferase 8 from soybean underlies resistance to the soybean cyst nematode

The Journal of biological chemistry, 2020-03, Vol.295 (11), p.3708-3718

2020

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Phosphorylation-Dependent Effects on the Structural Flexibility of Phosphoglucosamine Mutase from Bacillus anthracis

ACS omega, 2017-11, Vol.2 (11), p.8445-8452

2017

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Induced Structural Disorder as a Molecular Mechanism for Enzyme Dysfunction in Phosphoglucomutase 1 Deficiency

Journal of molecular biology, 2016-04, Vol.428 (8), p.1493-1505

2016

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Development of a Homogeneous Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) Assay for the Inhibition of Keap1–Nrf2 Protein–Protein Interaction

SLAS discovery, 2021-01, Vol.26 (1), p.100-112

2021

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Inhibitory Evaluation of αPMM/PGM from Pseudomonas aeruginosa: Chemical Synthesis, Enzyme Kinetics, and Protein Crystallographic Study

Journal of organic chemistry, 2019-08, Vol.84 (15), p.9627-9636

2019

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Mutations in hereditary phosphoglucomutase 1 deficiency map to key regions of enzyme structure and function

Discovery of a small-molecule inhibitor and cellular probe of Keap1–Nrf2 protein–protein interaction

Sequence-structure relationships, expression profiles, and disease-associated mutations in the paralogs of phosphoglucomutase 1

Enzyme dysfunction at atomic resolution: Disease-associated variants of human phosphoglucomutase-1

Optimization of fluorescently labeled Nrf2 peptide probes and the development of a fluorescence polarization assay for the discovery of inhibitors of Keap1-Nrf2 interaction

Phosphorylation in the Catalytic Cleft Stabilizes and Attracts Domains of a Phosphohexomutase

Crystal Structure of the Kelch Domain of Human Keap1

Defining the Phenotype and Assessing Severity in Phosphoglucomutase-1 Deficiency

Crystal Structure of Bacillus anthracis Phosphoglucosamine Mutase, an Enzyme in the Peptidoglycan Biosynthetic Pathway

A coevolutionary residue network at the site of a functionally important conformational change in a phosphohexomutase enzyme family

Multiple Ligand-Bound States of a Phosphohexomutase Revealed by Principal Component Analysis of NMR Peak Shifts

A Hotspot for Disease-Associated Variants of Human PGM1 Is Associated with Impaired Ligand Binding and Loop Dynamics

Data on the phosphorylation state of the catalytic serine of enzymes in the α-D-phosphohexomutase superfamily

Synthesis, Derivatization, and Structural Analysis of Phosphorylated Mono‑, Di‑, and Trifluorinated d‑Gluco-heptuloses by Glucokinase: Tunable Phosphoglucomutase Inhibition

Structural and dynamical description of the enzymatic reaction of a phosphohexomutase

Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling

Structural and functional analysis of two SHMT8 variants associated with soybean cyst nematode resistance

Compromised Catalysis and Potential Folding Defects in in Vitro Studies of Missense Mutants Associated with Hereditary Phosphoglucomutase 1 Deficiency

Crystal Structure of Human BPI and Two Bound Phospholipids at 2.4 Angstrom Resolution

Biology, Mechanism, and Structure of Enzymes in the α-d-Phosphohexomutase Superfamily

Impaired folate binding of serine hydroxymethyltransferase 8 from soybean underlies resistance to the soybean cyst nematode

Phosphorylation-Dependent Effects on the Structural Flexibility of Phosphoglucosamine Mutase from Bacillus anthracis

Induced Structural Disorder as a Molecular Mechanism for Enzyme Dysfunction in Phosphoglucomutase 1 Deficiency

Development of a Homogeneous Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) Assay for the Inhibition of Keap1–Nrf2 Protein–Protein Interaction

Inhibitory Evaluation of αPMM/PGM from Pseudomonas aeruginosa: Chemical Synthesis, Enzyme Kinetics, and Protein Crystallographic Study

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