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Identification of a Series of Tricyclic Natural Products as Potent Broad-Spectrum Inhibitors of Metallo-β-Lactamases

Antimicrobial Agents and Chemotherapy, 2002-06, Vol.46 (6), p.1880-1886

2002

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Crystal Structure of the IMP-1 Metallo β-Lactamase from Pseudomonas aeruginosa and Its Complex with a Mercaptocarboxylate Inhibitor: Binding Determinants of a Potent, Broad-Spectrum Inhibitor

Biochemistry (Easton), 2000-04, Vol.39 (15), p.4288-4298

2000

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Crystal Structure of the Zinc-Dependent β-Lactamase from Bacillus cereus at 1.9 Å Resolution: Binuclear Active Site with Features of a Mononuclear Enzyme

Biochemistry (Easton), 1998-09, Vol.37 (36), p.12404-12411

1998

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SAR of biphenyl carboxamide ligands of the human melanin-concentrating hormone receptor 1 (MCH R1): Discovery of antagonist SB-568849

Bioorganic & medicinal chemistry letters, 2006-09, Vol.16 (18), p.4865-4871

2006

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Thiocarbonyl-based 1,3-dipolarophiles for the synthesis of C(2)-unsubstituted penems

Pure and applied chemistry, 2005-12, Vol.77 (12), p.2033-2040

2005

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S-Alkyl Dithioformates as 1,3-Dipolarophiles. Generation of C(2)-Unsubstituted Penems

Organic letters, 2004-08, Vol.6 (16), p.2781-2783

2004

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beta-lactamase epidemiology and the utility of established and novel beta-lactamase inhibitors

Expert opinion on investigational drugs, 2000-02, Vol.9 (2), p.247-261

2000

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Characterization of Monomeric L1 Metallo-β-lactamase and the Role of the N-terminal Extension in Negative Cooperativity and Antibiotic Hydrolysis

The Journal of biological chemistry, 2002-07, Vol.277 (27), p.24744-24752

2002

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Inhibition of metallo-β-lactamases by a series of thiol ester derivatives of mercaptophenylacetic acid

FEMS microbiology letters, 1997-12, Vol.157 (1), p.171-175

1997

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NOVEL C-3 CYCLIC ETHER CEPHALOSPORINS AND THEIR ORALLY ABSORBED PRODRUG ESTERS

The Journal of Antibiotics, 1994/02/25, Vol.47(2), pp.253-256

1994

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Inhibition of metallo-β-lactamases by a series of thiol ester derivatives of mercaptophenylacetic acid

FEMS microbiology letters, 1997-12, Vol.157 (1), p.171-175

1997

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Olivanic acid analogues. Part 11. Ozonolysis of α-ethylideneazetidinones: ozonide fragmentation to α-amino acid-N-carboxyanhydrides

J. Chem. Soc., Perkin Trans. 1, 1992 (13), p.1577-1581

1992

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Perkin communications. Stereochemistry of substituted 1-alkoxybicyclo[2.2.2]octenes; Diels–Alder synthesis versus Tandem-Michael strategy

J. Chem. Soc., Perkin Trans. 1, 1991 (3), p.651-653

1991

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Olivanic acid analogues. Part 8. Halogenation and sulphenylation reactions leading selectively to cis-carbapenem precursors; stereospecific synthesis of (±)-6-epithienamycin

J. Chem. Soc., Perkin Trans. 1, 1991 (1), p.29-35

1991

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Synthesis of the 3-acetoxy-7-oxo-1-azabicyclo [3.2.0] hept-2-ene-2-carboxylate system

Tetrahedron letters, 1986, Vol.27 (49), p.6001-6004

1986

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Characterization of Monomeric L1 Metallo-Î²-lactamase and the Role of the N-terminal Extension in Negative Cooperativity and Antibiotic Hydrolysis

The Journal of biological chemistry, 2002-07, Vol.277 (27), p.24744

2002

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Olivanic acid analogues. Part 6. Biomimetic synthesis of (±)-PS-5, (±)-6-Epi-PS-5, and (±)-benzyl MM22381

J. Chem. Soc., Perkin Trans. 1, 1990 (6), p.1793-1801

1990

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The regioselectivity of cycloaddition reactions between diazomethane and 3-vinylcephalosporins

Journal of the Chemical Society, Perkin Transactions 1, 1991 (6), p.1361

1991

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Olivanic acid analogues. Part 5. Synthesis of 3-alkylthio and 3-alkylsulphinyl analogues via Michael addition of thiols to 3-unsubstituted 1-azabicyclo[3.2.0]hept-2-ene-2-carboxylates. X-Ray molecular structure of (2RS,3RS,5SR)-benzyl 3-ethylthio-7-oxo-1-azabicyclo[3.2.0]heptane-2-carboxylate and (2RS,3SR,5SR,6RS,1′RS)- and (2RS,3SR,5RS,6SR,1′SR)-benzyl 3-chloro-6-(1-hydroxyethyl)-7-oxo-3-[(SR)-phenylsulphinyl]-1-azabicyclo[3.2.0]heptane-2-carboxylate

J. Chem. Soc., Perkin Trans. 1, 1990 (6), p.1541-1553

1990

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Olivanic acid analogues. Part 10. X-Ray crystallographic study of the stereochemistry of some 7-heteroatom-substituted 7-acetyl-8-oxo-3-oxa-1-azabicyclo[4.2.0]octane-2-spirocyclohexanes: functional group control of the stereoselectivity of their reduction products using borohydride reagents

Journal of the Chemical Society, Perkin Transactions 1, 1992 (11), p.1305

1992

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Olivanic acid analogues. Part 7. Lead tetra-acetate oxidation of 3-alkylthio-7-oxo-1-azabicyclo[3.2.0]heptane-2-carboxylates

Journal of the Chemical Society, Perkin Transactions 1, 1990 (9), p.2553

1990

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Olivanic acid analogues. Part 2. Total synthesis of some C(6)-substituted 7-oxo-1 -azabicyclo[3.2.0] hept-2-ene-2-carboxylates

Journal of the Chemical Society, Perkin Transactions 1, 1985, p.2219

1985

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Olivanic acid analogues. Part 4. Cycloaddition reactions of p-nitrobenzyl 7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate, and synthesis of the 8-oxo-1-azatricyclo[4.2.0.02,4]octane-2-carboxylate system

Journal of the Chemical Society, Perkin Transactions 1, 1986, p.973

1986

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6-Spirocyclopropyl penems

Tetrahedron letters, 1993-03, Vol.34 (11), p.1799-1802

1993

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Synthesis of conformationally restricted analogues of the tryptophanyl tRNA synthetase inhibitor indolmycin

Tetrahedron letters, 1996-04, Vol.37 (17), p.3067-3070

1996

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Identification of a Series of Tricyclic Natural Products as Potent Broad-Spectrum Inhibitors of Metallo-β-Lactamases

Crystal Structure of the IMP-1 Metallo β-Lactamase from Pseudomonas aeruginosa and Its Complex with a Mercaptocarboxylate Inhibitor: Binding Determinants of a Potent, Broad-Spectrum Inhibitor

Crystal Structure of the Zinc-Dependent β-Lactamase from Bacillus cereus at 1.9 Å Resolution: Binuclear Active Site with Features of a Mononuclear Enzyme

SAR of biphenyl carboxamide ligands of the human melanin-concentrating hormone receptor 1 (MCH R1): Discovery of antagonist SB-568849

Thiocarbonyl-based 1,3-dipolarophiles for the synthesis of C(2)-unsubstituted penems

S-Alkyl Dithioformates as 1,3-Dipolarophiles. Generation of C(2)-Unsubstituted Penems

beta-lactamase epidemiology and the utility of established and novel beta-lactamase inhibitors

Characterization of Monomeric L1 Metallo-β-lactamase and the Role of the N-terminal Extension in Negative Cooperativity and Antibiotic Hydrolysis

Inhibition of metallo-β-lactamases by a series of thiol ester derivatives of mercaptophenylacetic acid

NOVEL C-3 CYCLIC ETHER CEPHALOSPORINS AND THEIR ORALLY ABSORBED PRODRUG ESTERS

Inhibition of metallo-β-lactamases by a series of thiol ester derivatives of mercaptophenylacetic acid

Olivanic acid analogues. Part 11. Ozonolysis of α-ethylideneazetidinones: ozonide fragmentation to α-amino acid-N-carboxyanhydrides

Perkin communications. Stereochemistry of substituted 1-alkoxybicyclo[2.2.2]octenes; Diels–Alder synthesis versus Tandem-Michael strategy

Olivanic acid analogues. Part 8. Halogenation and sulphenylation reactions leading selectively to cis-carbapenem precursors; stereospecific synthesis of (±)-6-epithienamycin

Synthesis of the 3-acetoxy-7-oxo-1-azabicyclo [3.2.0] hept-2-ene-2-carboxylate system

Characterization of Monomeric L1 Metallo-Î²-lactamase and the Role of the N-terminal Extension in Negative Cooperativity and Antibiotic Hydrolysis

Olivanic acid analogues. Part 6. Biomimetic synthesis of (±)-PS-5, (±)-6-Epi-PS-5, and (±)-benzyl MM22381

The regioselectivity of cycloaddition reactions between diazomethane and 3-vinylcephalosporins

Olivanic acid analogues. Part 10. X-Ray crystallographic study of the stereochemistry of some 7-heteroatom-substituted 7-acetyl-8-oxo-3-oxa-1-azabicyclo[4.2.0]octane-2-spirocyclohexanes: functional group control of the stereoselectivity of their reduction products using borohydride reagents

Olivanic acid analogues. Part 7. Lead tetra-acetate oxidation of 3-alkylthio-7-oxo-1-azabicyclo[3.2.0]heptane-2-carboxylates

Olivanic acid analogues. Part 2. Total synthesis of some C(6)-substituted 7-oxo-1 -azabicyclo[3.2.0] hept-2-ene-2-carboxylates

Olivanic acid analogues. Part 4. Cycloaddition reactions of p-nitrobenzyl 7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate, and synthesis of the 8-oxo-1-azatricyclo[4.2.0.02,4]octane-2-carboxylate system

6-Spirocyclopropyl penems

Synthesis of conformationally restricted analogues of the tryptophanyl tRNA synthetase inhibitor indolmycin

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