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Identification of Novel Potential Antibiotics against Staphylococcus Using Structure-Based Drug Screening Targeting Dihydrofolate Reductase

Journal of chemical information and modeling, 2014-04, Vol.54 (4), p.1242-1253

2014

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Evaluation of New Dihydrophthalazine-Appended 2,4-Diaminopyrimidines against Bacillus anthracis: Improved Syntheses Using a New Pincer Complex

Molecules (Basel, Switzerland), 2015-04, Vol.20 (4), p.7222-7244

2015

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Crystal Structure of Bacillus anthracis Dihydrofolate Reductase with the Dihydrophthalazine-Based Trimethoprim Derivative RAB1 Provides a Structural Explanation of Potency and Selectivity

Antimicrobial Agents and Chemotherapy, 2009-07, Vol.53 (7), p.3065-3073

2009

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Synthesis and biological evaluation of 2,4-diaminopyrimidine-based antifolate drugs against Bacillus anthracis

Molecules (Basel, Switzerland), 2014-03, Vol.19 (3), p.3231-3246

2014

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In Vitro Efficacy of New Antifolates against Trimethoprim-Resistant Bacillus anthracis

Antimicrobial Agents and Chemotherapy, 2007-12, Vol.51 (12), p.4447-4452

2007

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Functional Cloning of Bacillus anthracis Dihydrofolate Reductase and Confirmation of Natural Resistance to Trimethoprim

Antimicrobial Agents and Chemotherapy, 2004-12, Vol.48 (12), p.4643-4649

2004

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Use of Microsphere Technology for Targeted Delivery of Rifampin to Mycobacterium tuberculosis-Infected Macrophages

Antimicrobial Agents and Chemotherapy, 1998-10, Vol.42 (10), p.2682-2689

1998

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Antimycobacterial Activities of 2,4-Diamino-5-Deazapteridine Derivatives and Effects on Mycobacterial Dihydrofolate Reductase

Antimicrobial Agents and Chemotherapy, 2000-10, Vol.44 (10), p.2784-2793

2000

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Synthesis and biological activity of substituted 2,4-diaminopyrimidines that inhibit Bacillus anthracis

European journal of medicinal chemistry, 2012-08, Vol.54, p.387-396

2012

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Treatment of Tuberculosis Using a Combination of Sustained-Release Rifampin-Loaded Microspheres and Oral Dosing with Isoniazid

Antimicrobial Agents and Chemotherapy, 2001-06, Vol.45 (6), p.1637-1644

2001

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Modified 2,4-diaminopyrimidine-based dihydrofolate reductase inhibitors as potential drug scaffolds against Bacillus anthracis

Bioorganic & medicinal chemistry, 2015-01, Vol.23 (1), p.203-211

2015

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The Structure and Competitive Substrate Inhibition of Dihydrofolate Reductase from Enterococcus faecalis Reveal Restrictions to Cofactor Docking

Biochemistry (Easton), 2014-02, Vol.53 (7), p.1228-1238

2014

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Newly developed colorimetric drug screening assay for Bacillus anthracis

International journal of antimicrobial agents, 2006-02, Vol.27 (2), p.178-180

2006

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Anti-HIV natural product (+)-calanolide A is active against both drug-susceptible and drug-resistant strains of Mycobacterium tuberculosis

Bioorganic & medicinal chemistry, 2004-03, Vol.12 (5), p.1199-1207

2004

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Structure–activity relationship for enantiomers of potent inhibitors of B. anthracis dihydrofolate reductase

Biochimica et biophysica acta, 2013-01, Vol.1834 (1), p.46-52

2013

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Examination of intrinsic sulfonamide resistance in Bacillus anthracis: A novel assay for dihydropteroate synthase

Biochimica et biophysica acta, 2008-05, Vol.1780 (5), p.848-853

2008

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Establishment of a method for evaluating intracellular antibiotic efficacy in Brucella abortus-infected Mono Mac 6 monocytes

Journal of antimicrobial chemotherapy, 2008-01, Vol.61 (1), p.128-134

2008

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Microsphere technology for chemotherapy of mycobacterial infections

Current pharmaceutical design, 2004-01, Vol.10 (26), p.3275

Barrow, William W

2004

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Antimycobacterial activity of 2-methyl-adenosine

Journal of antimicrobial chemotherapy, 2003-11, Vol.52 (5), p.801-808

2003

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Comparative Study of the Frech Catalyst with Two Conventional Catalysts in the Heck Synthesis of 2,4-Diaminopyrimidine-based Antibiotics

Organic preparations and procedures international, 2013-01, Vol.45 (1), p.66-71

2013

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High-throughput screening of a diversity collection using biodefense category A and B priority pathogens

Journal of biomolecular screening, 2012-08, Vol.17 (7), p.946-956

2012

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Inside Cover: Inhibition of Bacterial Dihydrofolate Reductase by 6-Alkyl-2,4-diaminopyrimidines (ChemMedChem 11/2012)

ChemMedChem, 2012-11, Vol.7 (11), p.1866-1866

2012

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Classifying compound mechanism of action for linking whole cell phenotypes to molecular targets

Journal of molecular recognition, 2012-04, Vol.25 (4), p.216-223

2012

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Microwave-assisted Heck Synthesis of Substituted 2,4-Diaminopyrimidine-based Antibiotics

Organic preparations and procedures international, 2012-01, Vol.44 (3), p.281-287

2012

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Approaches to Iodinated Derivatives of Vanillin and Isovanillin

Organic preparations and procedures international, 2012-01, Vol.44 (2), p.146-152

2012

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Identification of Novel Potential Antibiotics against Staphylococcus Using Structure-Based Drug Screening Targeting Dihydrofolate Reductase

Evaluation of New Dihydrophthalazine-Appended 2,4-Diaminopyrimidines against Bacillus anthracis: Improved Syntheses Using a New Pincer Complex

Crystal Structure of Bacillus anthracis Dihydrofolate Reductase with the Dihydrophthalazine-Based Trimethoprim Derivative RAB1 Provides a Structural Explanation of Potency and Selectivity

Synthesis and biological evaluation of 2,4-diaminopyrimidine-based antifolate drugs against Bacillus anthracis

In Vitro Efficacy of New Antifolates against Trimethoprim-Resistant Bacillus anthracis

Functional Cloning of Bacillus anthracis Dihydrofolate Reductase and Confirmation of Natural Resistance to Trimethoprim

Use of Microsphere Technology for Targeted Delivery of Rifampin to Mycobacterium tuberculosis-Infected Macrophages

Antimycobacterial Activities of 2,4-Diamino-5-Deazapteridine Derivatives and Effects on Mycobacterial Dihydrofolate Reductase

Synthesis and biological activity of substituted 2,4-diaminopyrimidines that inhibit Bacillus anthracis

Treatment of Tuberculosis Using a Combination of Sustained-Release Rifampin-Loaded Microspheres and Oral Dosing with Isoniazid

Modified 2,4-diaminopyrimidine-based dihydrofolate reductase inhibitors as potential drug scaffolds against Bacillus anthracis

The Structure and Competitive Substrate Inhibition of Dihydrofolate Reductase from Enterococcus faecalis Reveal Restrictions to Cofactor Docking

Newly developed colorimetric drug screening assay for Bacillus anthracis

Anti-HIV natural product (+)-calanolide A is active against both drug-susceptible and drug-resistant strains of Mycobacterium tuberculosis

Structure–activity relationship for enantiomers of potent inhibitors of B. anthracis dihydrofolate reductase

Examination of intrinsic sulfonamide resistance in Bacillus anthracis: A novel assay for dihydropteroate synthase

Establishment of a method for evaluating intracellular antibiotic efficacy in Brucella abortus-infected Mono Mac 6 monocytes

Microsphere technology for chemotherapy of mycobacterial infections

Antimycobacterial activity of 2-methyl-adenosine

Comparative Study of the Frech Catalyst with Two Conventional Catalysts in the Heck Synthesis of 2,4-Diaminopyrimidine-based Antibiotics

High-throughput screening of a diversity collection using biodefense category A and B priority pathogens

Inside Cover: Inhibition of Bacterial Dihydrofolate Reductase by 6-Alkyl-2,4-diaminopyrimidines (ChemMedChem 11/2012)

Classifying compound mechanism of action for linking whole cell phenotypes to molecular targets

Microwave-assisted Heck Synthesis of Substituted 2,4-Diaminopyrimidine-based Antibiotics

Approaches to Iodinated Derivatives of Vanillin and Isovanillin

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