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Multiplexed immunoassay panel identifies novel CSF biomarkers for Alzheimer's disease diagnosis and prognosis

PloS one, 2011-04, Vol.6 (4), p.e18850-e18850

2011

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Class I HDAC inhibition is a novel pathway for regulating astrocytic apoE secretion

PloS one, 2018-03, Vol.13 (3), p.e0194661-e0194661

2018

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Human apoE isoforms differentially regulate brain amyloid-β peptide clearance

Science translational medicine, 2011-06, Vol.3 (89), p.89ra57

2011

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Brain lipid metabolism, apolipoprotein E and the pathophysiology of Alzheimer's disease

Neuropharmacology, 2010-09, Vol.59 (4), p.295-302

Bales, Kelly R.

2010

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Targeting apolipoprotein E for treating Alzheimer’s disease

Neuroscience letters, 2019-09, Vol.709, p.134366-134366, Article 134366

2019

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Human APOE isoform-dependent effects on brain beta-amyloid levels in PDAPP transgenic mice

The Journal of neuroscience, 2009-05, Vol.29 (21), p.6771-6779

2009

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The value and limitations of transgenic mouse models used in drug discovery for Alzheimer's disease: an update

Expert opinion on drug discovery, 2012-04, Vol.7 (4), p.281-297

Bales, Kelly R

2012

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Synaptic Activity Regulates Interstitial Fluid Amyloid-β Levels In Vivo

Neuron (Cambridge, Mass.), 2005-12, Vol.48 (6), p.913-922

2005

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Neuronal Sorting Protein-Related Receptor sorLA/LR11 Regulates Processing of the Amyloid Precursor Protein

Proceedings of the National Academy of Sciences - PNAS, 2005-09, Vol.102 (38), p.13461-13466

2005

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Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease

The Journal of clinical investigation, 2008-02, Vol.118 (2), p.671-682

2008

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Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-β peptides

Nature medicine, 2004-07, Vol.10 (7), p.719-726

2004

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γ-Secretase Modulator (GSM) Photoaffinity Probes Reveal Distinct Allosteric Binding Sites on Presenilin

The Journal of biological chemistry, 2013-04, Vol.288 (14), p.9710-9720

2013

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Enrichment improves cognition in AD mice by amyloid-related and unrelated mechanisms

Neurobiology of aging, 2007-06, Vol.28 (6), p.831-844

2007

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P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model

The Journal of clinical investigation, 2005-11, Vol.115 (11), p.3285-3290

2005

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Passive immunotherapy targeting amyloid-β reduces cerebral amyloid angiopathy and improves vascular reactivity

Brain (London, England : 1878), 2016-02, Vol.139 (Pt 2), p.563-577

2016

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Deletion of Abca1 Increases Aβ Deposition in the PDAPP Transgenic Mouse Model of Alzheimer Disease

The Journal of biological chemistry, 2005-12, Vol.280 (52), p.43236-43242

2005

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BMS-708,163 Targets Presenilin and Lacks Notch-Sparing Activity

Biochemistry (Easton), 2012-09, Vol.51 (37), p.7209-7211

2012

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Impact of variable domain glycosylation on antibody clearance: An LC/MS characterization

Analytical biochemistry, 2006-02, Vol.349 (2), p.197-207

2006

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Apolipoprotein E Isoform-Dependent Amyloid Deposition and Neuritic Degeneration in a Mouse Model of Alzheimer's Disease

Proceedings of the National Academy of Sciences - PNAS, 2000-03, Vol.97 (6), p.2892-2897

2000

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Brain to Plasma Amyloid-β Efflux: A Measure of Brain Amyloid Burden in a Mouse Model of Alzheimer's Disease

Science (American Association for the Advancement of Science), 2002-03, Vol.295 (5563), p.2264-2267

2002

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Genome-wide association study of CSF levels of 59 alzheimer's disease candidate proteins: significant associations with proteins involved in amyloid processing and inflammation

PLoS genetics, 2014-10, Vol.10 (10), p.e1004758-e1004758

2014

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The roles of inflammation and immune mechanisms in Alzheimer's disease

Alzheimer's & dementia : translational research & clinical interventions, 2016-06, Vol.2 (2), p.99-109

2016

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Human apolipoprotein E4 alters the amyloid-beta 40:42 ratio and promotes the formation of cerebral amyloid angiopathy in an amyloid precursor protein transgenic model

The Journal of neuroscience, 2005-03, Vol.25 (11), p.2803-2810

2005

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Phosphorylated Tau-Aβ42 Ratio as a Continuous Trait for Biomarker Discovery for Early-Stage Alzheimer’s Disease in Multiplex Immunoassay Panels of Cerebrospinal Fluid

Biological psychiatry (1969), 2014-05, Vol.75 (9), p.723-731

2014

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Immunization reverses memory deficits without reducing brain Aβ burden in Alzheimer's disease model

Nature neuroscience, 2002-05, Vol.5 (5), p.452-457

2002

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Multiplexed immunoassay panel identifies novel CSF biomarkers for Alzheimer's disease diagnosis and prognosis

Class I HDAC inhibition is a novel pathway for regulating astrocytic apoE secretion

Human apoE isoforms differentially regulate brain amyloid-β peptide clearance

Brain lipid metabolism, apolipoprotein E and the pathophysiology of Alzheimer's disease

Targeting apolipoprotein E for treating Alzheimer’s disease

Human APOE isoform-dependent effects on brain beta-amyloid levels in PDAPP transgenic mice

The value and limitations of transgenic mouse models used in drug discovery for Alzheimer's disease: an update

Synaptic Activity Regulates Interstitial Fluid Amyloid-β Levels In Vivo

Neuronal Sorting Protein-Related Receptor sorLA/LR11 Regulates Processing of the Amyloid Precursor Protein

Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease

Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-β peptides

γ-Secretase Modulator (GSM) Photoaffinity Probes Reveal Distinct Allosteric Binding Sites on Presenilin

Enrichment improves cognition in AD mice by amyloid-related and unrelated mechanisms

P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model

Passive immunotherapy targeting amyloid-β reduces cerebral amyloid angiopathy and improves vascular reactivity

Deletion of Abca1 Increases Aβ Deposition in the PDAPP Transgenic Mouse Model of Alzheimer Disease

BMS-708,163 Targets Presenilin and Lacks Notch-Sparing Activity

Impact of variable domain glycosylation on antibody clearance: An LC/MS characterization

Apolipoprotein E Isoform-Dependent Amyloid Deposition and Neuritic Degeneration in a Mouse Model of Alzheimer's Disease

Brain to Plasma Amyloid-β Efflux: A Measure of Brain Amyloid Burden in a Mouse Model of Alzheimer's Disease

Genome-wide association study of CSF levels of 59 alzheimer's disease candidate proteins: significant associations with proteins involved in amyloid processing and inflammation

The roles of inflammation and immune mechanisms in Alzheimer's disease

Human apolipoprotein E4 alters the amyloid-beta 40:42 ratio and promotes the formation of cerebral amyloid angiopathy in an amyloid precursor protein transgenic model

Phosphorylated Tau-Aβ42 Ratio as a Continuous Trait for Biomarker Discovery for Early-Stage Alzheimer’s Disease in Multiplex Immunoassay Panels of Cerebrospinal Fluid

Immunization reverses memory deficits without reducing brain Aβ burden in Alzheimer's disease model

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