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In-depth transcriptomic analysis of human retina reveals molecular mechanisms underlying diabetic retinopathy

Scientific reports, 2021-05, Vol.11 (1), p.10494-10494, Article 10494

2021

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The histamine H3 receptor: from gene cloning to H3 receptor drugs

Nature reviews. Drug discovery, 2005-02, Vol.4 (2), p.107-120

2005

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Transcriptome analysis of AAV-induced retinopathy models expressing human VEGF, TNF-α, and IL-6 in murine eyes

Scientific reports, 2022-11, Vol.12 (1), p.19395-19395, Article 19395

2022

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A Single Second Shell Amino Acid Determines Affinity and Kinetics of Linagliptin Binding to Type 4 Dipeptidyl Peptidase and Fibroblast Activation Protein

ChemMedChem, 2021-02, Vol.16 (4), p.630-639

2021

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Pharmacogenomic and structural analysis of constitutive G protein-coupled receptor activity

Annual review of pharmacology and toxicology, 2007-01, Vol.47 (1), p.53-87

2007

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Transcriptional comparison of adult human primary Retinal Pigment Epithelium, human pluripotent stem cell-derived Retinal Pigment Epithelium, and ARPE19 cells

Frontiers in cell and developmental biology, 2022-08, Vol.10, p.910040-910040

2022

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Evaluation of an Intravitreal Rho-Associated Kinase Inhibitor Depot Formulation in a Rat Model of Diabetic Retinopathy

Pharmaceutics, 2021-07, Vol.13 (8), p.1105

2021

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Amine oxidase copper-containing 3 (AOC3) inhibition: a potential novel target for the management of diabetic retinopathy

International journal of retina and vitreous, 2021-04, Vol.7 (1), p.30-30, Article 30

2021

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Comparative Analysis of Binding Kinetics and Thermodynamics of Dipeptidyl Peptidase‑4 Inhibitors and Their Relationship to Structure

Journal of medicinal chemistry, 2016-08, Vol.59 (16), p.7466-7477

2016

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Characterization of the Histamine H4 Receptor Binding Site. Part 1. Synthesis and Pharmacological Evaluation of Dibenzodiazepine Derivatives

Journal of medicinal chemistry, 2006-07, Vol.49 (15), p.4512-4516

2006

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BI-Y, an Neuropilin-1 Antagonist, Enhances Revascularization and Prevents Vascular Endothelial Growth Factor-A Induced Retinal Hyperpermeability in Rodent Models of Retinopathies

The Journal of pharmacology and experimental therapeutics, 2023-06, Vol.385 (3), p.214

2023

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Molecular determinants of ligand binding to H4R species variants

Molecular pharmacology, 2010-05, Vol.77 (5), p.734

2010

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Efficacy of an Anti-Semaphorin 3A Neutralizing Antibody in a Male Experimental Retinal Vein Occlusion Mouse Model

Investigative ophthalmology & visual science, 2022-07, Vol.63 (8), p.14-14

2022

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Phenylalanine 169 in the second extracellular loop of the human histamine H4 receptor is responsible for the difference in agonist binding between human and mouse H4 receptors

The Journal of pharmacology and experimental therapeutics, 2008-10, Vol.327 (1), p.88

2008

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Cloning and characterization of dominant negative splice variants of the human histamine H4 receptor

Biochemical journal, 2008-08, Vol.414 (1), p.121-131

2008

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Molecular aspects of the histamine H3 receptor

Biochemical pharmacology, 2007-04, Vol.73 (8), p.1195-1204

2007

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Constitutive activity of the histamine H1 receptor reveals inverse agonism of histamine H1 receptor antagonists

European journal of pharmacology, 2000-11, Vol.387 (1), p.R5-R7

2000

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Domain swapping in the human histamine H1 receptor

The Journal of pharmacology and experimental therapeutics, 2004-10, Vol.311 (1), p.131

2004

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Discovery of Naturally Occurring Splice Variants of the Rat Histamine H3 Receptor That Act as Dominant-Negative Isoforms

Molecular pharmacology, 2006-04, Vol.69 (4), p.1194-1206

2006

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An 80-amino acid deletion in the third intracellular loop of a naturally occurring human histamine H3 isoform confers pharmacological differences and constitutive activity

The Journal of pharmacology and experimental therapeutics, 2007-12, Vol.323 (3), p.888

2007

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GPCR Proteomics: Mass Spectrometric and Functional Analysis of Histamine H1 Receptor after Baculovirus-Driven and in Vitro Cell Free Expression

Journal of proteome research, 2008-02, Vol.7 (2), p.621-629

2008

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A Selective Human H4-Receptor Agonist: (−)-2-Cyano-1-methyl-3-{(2R,5R)-5- [1H-imidazol-4(5)-yl]tetrahydrofuran-2-yl}methylguanidine

Journal of medicinal chemistry, 2003-07, Vol.46 (14), p.3162-3165

2003

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Constitutively Active Mutants of the Histamine H1 Receptor Suggest a Conserved Hydrophobic Asparagine-Cage That Constrains the Activation of Class A G Protein-Coupled Receptors

Molecular pharmacology, 2008-01, Vol.73 (1), p.94

2008

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Sema3A Antibody BI-X Prevents Cell Permeability and Cytoskeletal Collapse in HRMECs and Increases Tip Cell Density in Mouse Oxygen-Induced Retinopathy

Translational vision science & technology, 2022-06, Vol.11 (6), p.17-17

2022

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Mutational analysis of the histamine H1-receptor binding pocket of histaprodifens

European journal of pharmacology, 2004-03, Vol.487 (1-3), p.55-63

2004

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In-depth transcriptomic analysis of human retina reveals molecular mechanisms underlying diabetic retinopathy

The histamine H3 receptor: from gene cloning to H3 receptor drugs

Transcriptome analysis of AAV-induced retinopathy models expressing human VEGF, TNF-α, and IL-6 in murine eyes

A Single Second Shell Amino Acid Determines Affinity and Kinetics of Linagliptin Binding to Type 4 Dipeptidyl Peptidase and Fibroblast Activation Protein

Pharmacogenomic and structural analysis of constitutive G protein-coupled receptor activity

Transcriptional comparison of adult human primary Retinal Pigment Epithelium, human pluripotent stem cell-derived Retinal Pigment Epithelium, and ARPE19 cells

Evaluation of an Intravitreal Rho-Associated Kinase Inhibitor Depot Formulation in a Rat Model of Diabetic Retinopathy

Amine oxidase copper-containing 3 (AOC3) inhibition: a potential novel target for the management of diabetic retinopathy

Comparative Analysis of Binding Kinetics and Thermodynamics of Dipeptidyl Peptidase‑4 Inhibitors and Their Relationship to Structure

Characterization of the Histamine H4 Receptor Binding Site. Part 1. Synthesis and Pharmacological Evaluation of Dibenzodiazepine Derivatives

BI-Y, an Neuropilin-1 Antagonist, Enhances Revascularization and Prevents Vascular Endothelial Growth Factor-A Induced Retinal Hyperpermeability in Rodent Models of Retinopathies

Molecular determinants of ligand binding to H4R species variants

Efficacy of an Anti-Semaphorin 3A Neutralizing Antibody in a Male Experimental Retinal Vein Occlusion Mouse Model

Phenylalanine 169 in the second extracellular loop of the human histamine H4 receptor is responsible for the difference in agonist binding between human and mouse H4 receptors

Cloning and characterization of dominant negative splice variants of the human histamine H4 receptor

Molecular aspects of the histamine H3 receptor

Constitutive activity of the histamine H1 receptor reveals inverse agonism of histamine H1 receptor antagonists

Domain swapping in the human histamine H1 receptor

Discovery of Naturally Occurring Splice Variants of the Rat Histamine H3 Receptor That Act as Dominant-Negative Isoforms

An 80-amino acid deletion in the third intracellular loop of a naturally occurring human histamine H3 isoform confers pharmacological differences and constitutive activity

GPCR Proteomics: Mass Spectrometric and Functional Analysis of Histamine H1 Receptor after Baculovirus-Driven and in Vitro Cell Free Expression

A Selective Human H4-Receptor Agonist: (−)-2-Cyano-1-methyl-3-{(2R,5R)-5- [1H-imidazol-4(5)-yl]tetrahydrofuran-2-yl}methylguanidine

Constitutively Active Mutants of the Histamine H1 Receptor Suggest a Conserved Hydrophobic Asparagine-Cage That Constrains the Activation of Class A G Protein-Coupled Receptors

Sema3A Antibody BI-X Prevents Cell Permeability and Cytoskeletal Collapse in HRMECs and Increases Tip Cell Density in Mouse Oxygen-Induced Retinopathy

Mutational analysis of the histamine H1-receptor binding pocket of histaprodifens

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