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Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway

Cancer cell, 2004-07, Vol.6 (1), p.33-43

2004

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Bengamides Revisited: New Structures and Antitumor Studies

Journal of organic chemistry, 2001-03, Vol.66 (5), p.1733-1741

2001

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Structural and Conformational Requirements for High-Affinity Binding to the SH2 Domain of Grb2

Journal of medicinal chemistry, 1999-03, Vol.42 (6), p.971-980

1999

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Synthesis and Antitumor Activity of Ester-Modified Analogues of Bengamide B

Journal of medicinal chemistry, 2001-10, Vol.44 (22), p.3692-3699

2001

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Proteomics-based target identification: bengamides as a new class of methionine aminopeptidase inhibitors

The Journal of biological chemistry, 2003-12, Vol.278 (52), p.52964-52971

2003

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Selective Killing of Transformed Cells by Cyclin/Cyclin-Dependent Kinase 2 Antagonists

Proceedings of the National Academy of Sciences - PNAS, 1999-04, Vol.96 (8), p.4325-4329

1999

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Total Syntheses of Bengamides B and E

Journal of organic chemistry, 2001-03, Vol.66 (6), p.2118-2122

2001

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Analysis of the interactions of SDZ PSC 833 ([3'-keto-Bmt1]-Val2]-Cyclosporine), a multidrug resistance modulator, with P-glycoprotein

Oncology research, 1995, Vol.7 (12), p.603

1995

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Hairpin versus Extended DNA Binding of a Substituted β-Alanine Linked Polyamide

Journal of the American Chemical Society, 2002-03, Vol.124 (10), p.2148-2152

2002

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Solid-phase total synthesis of polymyxin B1

The journal of peptide research, 1999-05, Vol.53 (5), p.501-506

1999

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The reversal of multidrug resistance in multicellular tumor spheroids by SDZ PSC 833

Anticancer research, 1997-01, Vol.17 (1A), p.129

1997

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Polyploidy induction as a consequence of topoisomerase inhibition: A flow cytometric assessment

Biochemical pharmacology, 1991-11, Vol.42 (11), p.2199-2208

1991

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Molecular Approaches to Discover Marine Natural Product Anticancer Leads - An Update from a Drug Discovery Group Collaboration

Pharmaceutical biology, 2003, Vol.41 (s1), p.39-52

2003

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Psammaplins from the Sponge Pseudoceratina purpurea: Inhibition of Both Histone Deacetylase and DNA Methyltransferase

Journal of organic chemistry, 2003-05, Vol.68 (10), p.3866-3873

2003

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Identification of E2F-1/Cyclin A antagonists

Bioorganic & medicinal chemistry letters, 2001-09, Vol.11 (18), p.2449-2452

2001

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Correlation of cytotoxicity and protein-associated DNA strand breaks for 2-(arylmethylamino)-1,3-propanediols

Anti-cancer drug design, 1998-10, Vol.13 (7), p.825

1998

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Effects of isomeric 2-(arylmethylamino)-1,3-propanediols (AMAPs) and clinically established agents on macromolecular synthesis in P388 and MCF-7 cells

Investigational new drugs, 1991-05, Vol.9 (2), p.125-136

1991

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N-Hydroxy-3-phenyl-2-propenamides as Novel Inhibitors of Human Histone Deacetylase with in Vivo Antitumor Activity: Discovery of (2E)-N-Hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide (NVP-LAQ824)

Journal of medicinal chemistry, 2003-10, Vol.46 (21), p.4609-4624

2003

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Inhibitors of Human Histone Deacetylase: Synthesis and Enzyme and Cellular Activity of Straight Chain Hydroxamates

Journal of medicinal chemistry, 2002-02, Vol.45 (4), p.753-757

2002

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An efficient multiple-exposure analysis of the toxicity of crisnatol, a DNA intercalator in phase II clinical trials

Investigational new drugs, 1992-04, Vol.10 (1), p.1-15

1992

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Phase I and clinical pharmacology trial of 502U83 using a monthly single dose schedule

Cancer research (Chicago, Ill.), 1990-12, Vol.50 (23), p.7496-7500

1990

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(1-Pyrenylmethyl)amino alcohols, a new class of antitumor DNA intercalators. Discovery and initial amine side chain structure-activity studies

Journal of medicinal chemistry, 1990-09, Vol.33 (9), p.2385-2393

1990

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2-[(Arylmethyl)amino]-2-methyl-1,3-propanediol DNA intercalators. An examination of the effects of aromatic ring variation on antitumor activity and DNA binding

Journal of medicinal chemistry, 1991-07, Vol.34 (7), p.1983-1990

1991

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Limitations of the fluorescent probe viability assay

Molecular toxicology, 1989-10, Vol.2 (4), p.271

1989

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Phase I evaluation of 773U82.HCl, a member of a new class of DNA intercalators

Anti-cancer drugs, 1991-08, Vol.2 (4), p.357

1991

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Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway

Bengamides Revisited: New Structures and Antitumor Studies

Structural and Conformational Requirements for High-Affinity Binding to the SH2 Domain of Grb2

Synthesis and Antitumor Activity of Ester-Modified Analogues of Bengamide B

Proteomics-based target identification: bengamides as a new class of methionine aminopeptidase inhibitors

Selective Killing of Transformed Cells by Cyclin/Cyclin-Dependent Kinase 2 Antagonists

Total Syntheses of Bengamides B and E

Analysis of the interactions of SDZ PSC 833 ([3'-keto-Bmt1]-Val2]-Cyclosporine), a multidrug resistance modulator, with P-glycoprotein

Hairpin versus Extended DNA Binding of a Substituted β-Alanine Linked Polyamide

Solid-phase total synthesis of polymyxin B1

The reversal of multidrug resistance in multicellular tumor spheroids by SDZ PSC 833

Polyploidy induction as a consequence of topoisomerase inhibition: A flow cytometric assessment

Molecular Approaches to Discover Marine Natural Product Anticancer Leads - An Update from a Drug Discovery Group Collaboration

Psammaplins from the Sponge Pseudoceratina purpurea: Inhibition of Both Histone Deacetylase and DNA Methyltransferase

Identification of E2F-1/Cyclin A antagonists

Correlation of cytotoxicity and protein-associated DNA strand breaks for 2-(arylmethylamino)-1,3-propanediols

Effects of isomeric 2-(arylmethylamino)-1,3-propanediols (AMAPs) and clinically established agents on macromolecular synthesis in P388 and MCF-7 cells

N-Hydroxy-3-phenyl-2-propenamides as Novel Inhibitors of Human Histone Deacetylase with in Vivo Antitumor Activity: Discovery of (2E)-N-Hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide (NVP-LAQ824)

Inhibitors of Human Histone Deacetylase: Synthesis and Enzyme and Cellular Activity of Straight Chain Hydroxamates

An efficient multiple-exposure analysis of the toxicity of crisnatol, a DNA intercalator in phase II clinical trials

Phase I and clinical pharmacology trial of 502U83 using a monthly single dose schedule

(1-Pyrenylmethyl)amino alcohols, a new class of antitumor DNA intercalators. Discovery and initial amine side chain structure-activity studies

2-[(Arylmethyl)amino]-2-methyl-1,3-propanediol DNA intercalators. An examination of the effects of aromatic ring variation on antitumor activity and DNA binding

Limitations of the fluorescent probe viability assay

Phase I evaluation of 773U82.HCl, a member of a new class of DNA intercalators

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