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The Janus kinase 2 inhibitor fedratinib inhibits thiamine uptake: a putative mechanism for the onset of Wernicke's encephalopathy

Drug metabolism and disposition, 2014-10, Vol.42 (10), p.1656-1662

2014

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Species-specific metabolism of SGX523 by aldehyde oxidase and the toxicological implications

Drug metabolism and disposition, 2010-08, Vol.38 (8), p.1277-1285

2010

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Preclinical characterization of INCB053914, a novel pan-PIM kinase inhibitor, alone and in combination with anticancer agents, in models of hematologic malignancies

PloS one, 2018-06, Vol.13 (6), p.e0199108-e0199108

2018

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A comprehensive listing of bioactivation pathways of organic functional groups

Current drug metabolism, 2005-06, Vol.6 (3), p.161-225

2005

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2020 White Paper on Recent Issues in Bioanalysis: BMV of Hybrid Assays, Acoustic MS, HRMS, Data Integrity, Endogenous Compounds, Microsampling and Microbiome

Bioanalysis, 2021-02, Vol.13 (4), p.203-238

2021

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Biotransformation: Impact and Application of Metabolism in Drug Discovery

ACS medicinal chemistry letters, 2020-11, Vol.11 (11), p.2087-2107

2020

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Metabolite Bioanalysis in Drug Development: Recommendations from the IQ Consortium Metabolite Bioanalysis Working Group

Clinical pharmacology and therapeutics, 2024-05, Vol.115 (5), p.939-953

2024

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A Novel Kinase Inhibitor, INCB28060, Blocks c-MET-Dependent Signaling, Neoplastic Activities, and Cross-Talk with EGFR and HER-3

Clinical cancer research, 2011-11, Vol.17 (22), p.7127-7138

2011

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In Vitro Interactions of Epacadostat and its Major Metabolites with Human Efflux and Uptake Transporters: Implications for Pharmacokinetics and Drug Interactions

Drug metabolism and disposition, 2017-06, Vol.45 (6), p.612-623

2017

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Roles of UGT, P450, and Gut Microbiota in the Metabolism of Epacadostat in Humans

Drug metabolism and disposition, 2016-10, Vol.44 (10), p.1668-1674

2016

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2023 White Paper on Recent Issues in Bioanalysis: Deuterated Drugs; LNP; Tumor/FFPE Biopsy; Targeted Proteomics; Small Molecule Covalent Inhibitors; Chiral Bioanalysis; Remote Regulatory Assessments; Sample Reconciliation/Chain of Custody (PART 1A - Recommendations on Mass Spectrometry, Chromatography, Sample Preparation Latest Developments, Challenges, and Solutions and BMV/Regulated Bioanalysis PART 1B - Regulatory Agencies' Inputs on Regulated Bioanalysis/BMV, Biomarkers/IVD/CDx/BAV, Immunoge

Bioanalysis, 2024-05, Vol.16 (9), p.307-364

2024

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Abstract 5900: INCB161734: A novel, potent, and orally bioavailable KRAS G12D selective inhibitor demonstrates antitumor activity in KRAS G12D mutant tumors

Cancer research (Chicago, Ill.), 2024-03, Vol.84 (6_Supplement), p.5900-5900

2024

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Abstract 5416: Activity of the pan-PIM kinase inhibitor INCB053914 in models of acute myelogenous leukemia

Cancer research (Chicago, Ill.), 2015-08, Vol.75 (15_Supplement), p.5416-5416

2015

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Sulfoximine-substituted trifluoromethylpyrimidine analogs as inhibitors of proline-rich tyrosine kinase 2 (PYK2) show reduced hERG activity

Bioorganic & medicinal chemistry letters, 2009-06, Vol.19 (12), p.3253-3258

2009

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Abstract 5414: Activity of the pan-PIM kinase inhibitor INCB053914 in models of multiple myeloma

Cancer research (Chicago, Ill.), 2015-08, Vol.75 (15_Supplement), p.5414-5414

2015

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Peer Review Innovations: Insights and Ideas from the Researcher to Reader 2024 Workshop

Science Editor, 2024-04

2024

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Mechanistic investigation of cytochrome P450 1A2 catalyzed metabolism of 8-alkylxanthines

Boer, Jason Lee

2003

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The Fatal "Theory-Fiction" of Jean Baudrillard

International journal of Baudrillard studies, 2005-01, Vol.2 (1)

De Boer, Jason

2005

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The complexities inherent in attempts to decrease drug clearance by blocking sites of CYP-mediated metabolism

Current opinion in drug discovery & development, 2006-01, Vol.9 (1), p.101

2006

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Proteomic and Biochemical Studies of Lysine Malonylation Suggest Its Malonic Aciduria-associated Regulatory Role in Mitochondrial Function and Fatty Acid Oxidation[S]

Molecular & cellular proteomics, 2015-11, Vol.14 (11), p.3056-3071

2015

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Trait Differentiation within the Fungus-Feeding (Mycophagous) Bacterial Genus Collimonas

PloS one, 2016-06, Vol.11 (6), p.e0157552-e0157552

2016

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Poor-quality monitoring data underestimate the impact of Australia's megafires on a critically endangered songbird

Diversity & distributions, 2022-03, Vol.28 (3), p.506-514

2022

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Return-to-work coordination programmes for improving return to work in workers on sick leave

Cochrane database of systematic reviews, 2017-03, Vol.3 (3), p.CD011618

2017

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Return to work coordination programmes for work disability: a meta-analysis of randomised controlled trials

PloS one, 2012-11, Vol.7 (11), p.e49760-e49760

2012

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Field test of electrokinetically-delivered thermally activated persulfate for remediation of chlorinated solvents in clay

Water research (Oxford), 2020-09, Vol.183, p.116061-116061, Article 116061

2020

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The Janus kinase 2 inhibitor fedratinib inhibits thiamine uptake: a putative mechanism for the onset of Wernicke's encephalopathy

Species-specific metabolism of SGX523 by aldehyde oxidase and the toxicological implications

Preclinical characterization of INCB053914, a novel pan-PIM kinase inhibitor, alone and in combination with anticancer agents, in models of hematologic malignancies

A comprehensive listing of bioactivation pathways of organic functional groups

2020 White Paper on Recent Issues in Bioanalysis: BMV of Hybrid Assays, Acoustic MS, HRMS, Data Integrity, Endogenous Compounds, Microsampling and Microbiome

Biotransformation: Impact and Application of Metabolism in Drug Discovery

Metabolite Bioanalysis in Drug Development: Recommendations from the IQ Consortium Metabolite Bioanalysis Working Group

A Novel Kinase Inhibitor, INCB28060, Blocks c-MET-Dependent Signaling, Neoplastic Activities, and Cross-Talk with EGFR and HER-3

In Vitro Interactions of Epacadostat and its Major Metabolites with Human Efflux and Uptake Transporters: Implications for Pharmacokinetics and Drug Interactions

Roles of UGT, P450, and Gut Microbiota in the Metabolism of Epacadostat in Humans

Abstract 5900: INCB161734: A novel, potent, and orally bioavailable KRAS G12D selective inhibitor demonstrates antitumor activity in KRAS G12D mutant tumors

Abstract 5416: Activity of the pan-PIM kinase inhibitor INCB053914 in models of acute myelogenous leukemia

Sulfoximine-substituted trifluoromethylpyrimidine analogs as inhibitors of proline-rich tyrosine kinase 2 (PYK2) show reduced hERG activity

Abstract 5414: Activity of the pan-PIM kinase inhibitor INCB053914 in models of multiple myeloma

Peer Review Innovations: Insights and Ideas from the Researcher to Reader 2024 Workshop

Mechanistic investigation of cytochrome P450 1A2 catalyzed metabolism of 8-alkylxanthines

The Fatal "Theory-Fiction" of Jean Baudrillard

The complexities inherent in attempts to decrease drug clearance by blocking sites of CYP-mediated metabolism

Proteomic and Biochemical Studies of Lysine Malonylation Suggest Its Malonic Aciduria-associated Regulatory Role in Mitochondrial Function and Fatty Acid Oxidation[S]

Trait Differentiation within the Fungus-Feeding (Mycophagous) Bacterial Genus Collimonas

Poor-quality monitoring data underestimate the impact of Australia's megafires on a critically endangered songbird

Return-to-work coordination programmes for improving return to work in workers on sick leave

Return to work coordination programmes for work disability: a meta-analysis of randomised controlled trials

Field test of electrokinetically-delivered thermally activated persulfate for remediation of chlorinated solvents in clay

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