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Pan-PIM Kinase Inhibition Provides a Novel Therapy for Treating Hematologic Cancers

Clinical cancer research, 2014-04, Vol.20 (7), p.1834-1845

2014

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Identification of N‑(4-((1R,3S,5S)‑3-Amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide (PIM447), a Potent and Selective Proviral Insertion Site of Moloney Murine Leukemia (PIM) 1, 2, and 3 Kinase Inhibitor in Clinical Trials for Hematological Malignancies

Journal of medicinal chemistry, 2015-11, Vol.58 (21), p.8373-8386

2015

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Multiple Solvent Crystal Structures: Probing Binding Sites, Plasticity and Hydration

Journal of molecular biology, 2006-04, Vol.357 (5), p.1471-1482

2006

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Optimization of a Dibenzodiazepine Hit to a Potent and Selective Allosteric PAK1 Inhibitor

ACS medicinal chemistry letters, 2015-07, Vol.6 (7), p.776-781

2015

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SU9516: biochemical analysis of cdk inhibition and crystal structure in complex with cdk2

Biochemical and biophysical research communications, 2003-10, Vol.310 (3), p.1026-1031

2003

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Targeting cancer: the challenges and successes of structure-based drug design against the human purinome

Current topics in medicinal chemistry, 2006-06, Vol.6 (11), p.1129-1159

2006

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Topoisomerase Inhibitors Addressing Fluoroquinolone Resistance in Gram-Negative Bacteria

Journal of medicinal chemistry, 2020-07, Vol.63 (14), p.7773-7816

2020

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Synthesis and Structure–Activity Relationship of Tetra-Substituted Cyclohexyl Diol Inhibitors of Proviral Insertion of Moloney Virus (PIM) Kinases

Journal of medicinal chemistry, 2020-12, Vol.63 (23), p.14885-14904

2020

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Application of Virtual Screening to the Identification of New LpxC Inhibitor Chemotypes, Oxazolidinone and Isoxazoline

Journal of medicinal chemistry, 2018-10, Vol.61 (20), p.9360-9370

2018

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Discovery and Optimization of DNA Gyrase and Topoisomerase IV Inhibitors with Potent Activity against Fluoroquinolone-Resistant Gram-Positive Bacteria

Journal of medicinal chemistry, 2021-05, Vol.64 (9), p.6329-6357

2021

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The nicotinamide dinucleotide binding motif: a comparison of nucleotide binding proteins

The FASEB journal, 1996-09, Vol.10 (11), p.1257-1269

Bellamacina, Cornelia R.

1996

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Ligand efficient tetrahydro-pyrazolopyridines as inhibitors of ERK2 kinase

Bioorganic & medicinal chemistry letters, 2015-09, Vol.25 (17), p.3626-3629

2015

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Discovery of novel 3,5-disubstituted indole derivatives as potent inhibitors of Pim-1, Pim-2, and Pim-3 protein kinases

Bioorganic & medicinal chemistry letters, 2011-11, Vol.21 (21), p.6366-6369

2011

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Design, synthesis and structure activity relationship of potent pan-PIM kinase inhibitors derived from the pyridyl carboxamide scaffold

Bioorganic & medicinal chemistry letters, 2016-05, Vol.26 (9), p.2328-2332

2016

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An Experimental Approach to Mapping the Binding Surfaces of Crystalline Proteins

Journal of physical chemistry (1952), 1996-02, Vol.100 (7), p.2605-2611

1996

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Design, Structure–Activity Relationship, and in Vivo Characterization of the Development Candidate NVP-HSP990

Journal of medicinal chemistry, 2014-11, Vol.57 (21), p.9124-9129

2014

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Structure Guided Optimization, in Vitro Activity, and in Vivo Activity of Pan-PIM Kinase Inhibitors

ACS medicinal chemistry letters, 2013-12, Vol.4 (12), p.1193-1197

2013

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Purification, crystallization and molecular symmetry of CDP-d-glucose 4,6-dehydratase from Yersinia pseudotuberculosis

Acta crystallographica. Section D, Biological crystallography., 2002-02, Vol.58 (2), p.370-373

2002

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4-(1 H-Indazol-5-yl)-6-phenylpyrimidin-2(1 H)-one analogs as potent CDC7 inhibitors

Bioorganic & medicinal chemistry, 2008-08, Vol.18 (16), p.4482-4485

2008

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Crystal Structure at 1.8 Å Resolution of CDP-d-Glucose 4,6-Dehydratase from Yersinia pseudotuberculosis

Biochemistry (Easton), 2004-03, Vol.43 (11), p.3057-3067

2004

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Partial determination of the crystal structure of CDP-D-glucose dehydratase and the experimental analysis of the binding surfaces of elastase using the multiple solvent crystal structures method: Analysis of the water binding sites

Bellamacina, Cornelia R

1997

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Pan-PIM Kinase Inhibition Provides a Novel Therapy for Treating Hematologic Cancers

Identification of N‑(4-((1R,3S,5S)‑3-Amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide (PIM447), a Potent and Selective Proviral Insertion Site of Moloney Murine Leukemia (PIM) 1, 2, and 3 Kinase Inhibitor in Clinical Trials for Hematological Malignancies

Multiple Solvent Crystal Structures: Probing Binding Sites, Plasticity and Hydration

Optimization of a Dibenzodiazepine Hit to a Potent and Selective Allosteric PAK1 Inhibitor

SU9516: biochemical analysis of cdk inhibition and crystal structure in complex with cdk2

Targeting cancer: the challenges and successes of structure-based drug design against the human purinome

Topoisomerase Inhibitors Addressing Fluoroquinolone Resistance in Gram-Negative Bacteria

Synthesis and Structure–Activity Relationship of Tetra-Substituted Cyclohexyl Diol Inhibitors of Proviral Insertion of Moloney Virus (PIM) Kinases

Application of Virtual Screening to the Identification of New LpxC Inhibitor Chemotypes, Oxazolidinone and Isoxazoline

Discovery and Optimization of DNA Gyrase and Topoisomerase IV Inhibitors with Potent Activity against Fluoroquinolone-Resistant Gram-Positive Bacteria

The nicotinamide dinucleotide binding motif: a comparison of nucleotide binding proteins

Ligand efficient tetrahydro-pyrazolopyridines as inhibitors of ERK2 kinase

Discovery of novel 3,5-disubstituted indole derivatives as potent inhibitors of Pim-1, Pim-2, and Pim-3 protein kinases

Design, synthesis and structure activity relationship of potent pan-PIM kinase inhibitors derived from the pyridyl carboxamide scaffold

An Experimental Approach to Mapping the Binding Surfaces of Crystalline Proteins

Design, Structure–Activity Relationship, and in Vivo Characterization of the Development Candidate NVP-HSP990

Structure Guided Optimization, in Vitro Activity, and in Vivo Activity of Pan-PIM Kinase Inhibitors

Purification, crystallization and molecular symmetry of CDP-d-glucose 4,6-dehydratase from Yersinia pseudotuberculosis

4-(1 H-Indazol-5-yl)-6-phenylpyrimidin-2(1 H)-one analogs as potent CDC7 inhibitors

Crystal Structure at 1.8 Å Resolution of CDP-d-Glucose 4,6-Dehydratase from Yersinia pseudotuberculosis

Partial determination of the crystal structure of CDP-D-glucose dehydratase and the experimental analysis of the binding surfaces of elastase using the multiple solvent crystal structures method: Analysis of the water binding sites

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