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Anti-Inflammatory Effects of Omega-3 Fatty Acids in the Brain: Physiological Mechanisms and Relevance to Pharmacology

Pharmacological reviews, 2018-01, Vol.70 (1), p.12-38

2018

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Updates to the n-3 polyunsaturated fatty acid biosynthesis pathway: DHA synthesis rates, tetracosahexaenoic acid and (minimal) retroconversion

Progress in lipid research, 2019-10, Vol.76, p.101008-101008, Article 101008

2019

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Projected declines in global DHA availability for human consumption as a result of global warming

Ambio, 2020-04, Vol.49 (4), p.865-880

2020

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ACSL6 is critical for maintaining brain DHA levels

Proceedings of the National Academy of Sciences - PNAS, 2018-12, Vol.115 (49), p.12343-12345

2018

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Polyunsaturated fatty acids and their metabolites in brain function and disease

Nature reviews. Neuroscience, 2014-12, Vol.15 (12), p.771-785

2014

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Brain eicosapentaenoic acid metabolism as a lead for novel therapeutics in major depression

Brain, behavior, and immunity, 2020-03, Vol.85, p.21-28

2020

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Novel 13C enrichment technique reveals early turnover of DHA in peripheral tissues

Journal of lipid research, 2023-05, Vol.64 (5), p.100357-100357, Article 100357

2023

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Do Eicosapentaenoic Acid and Docosahexaenoic Acid Have the Potential to Compete against Each Other?

Nutrients, 2020-12, Vol.12 (12), p.3718

2020

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Plasma non-esterified docosahexaenoic acid is the major pool supplying the brain

Scientific reports, 2015-10, Vol.5 (1), p.15791-15791, Article 15791

2015

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Turnover of brain DHA in mice is accurately determined by tracer-free natural abundance carbon isotope ratio analysis

Journal of lipid research, 2020-01, Vol.61 (1), p.116-126

2020

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Upregulated hepatic lipogenesis from dietary sugars in response to low palmitate feeding supplies brain palmitate

Nature communications, 2024-01, Vol.15 (1), p.490-490, Article 490

2024

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Effect of dietary docosahexaenoic acid (DHA) in phospholipids or triglycerides on brain DHA uptake and accretion

The Journal of nutritional biochemistry, 2016-07, Vol.33, p.91-102

2016

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Dietary docosahexaenoic acid (DHA) downregulates liver DHA synthesis by inhibiting eicosapentaenoic acid elongation

Journal of lipid research, 2024-06, Vol.65 (6), p.100548, Article 100548

2024

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Brain oxylipin concentrations following hypercapnia/ischemia: effects of brain dissection and dissection time[S]

Journal of lipid research, 2019-03, Vol.60 (3), p.671-682

2019

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Analysis of omega-3 and omega-6 polyunsaturated fatty acid metabolism by compound-specific isotope analysis in humans

Journal of lipid research, 2023-09, Vol.64 (9), p.100424-100424, Article 100424

2023

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Oleic acid‐bound FABP7 drives glioma cell proliferation through regulation of nuclear lipid droplet formation

The FEBS journal, 2023-04, Vol.290 (7), p.1798-1821

2023

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Rapid de‐esterification and loss of eicosapentaenoic acid from rat brain phospholipids: an intracerebroventricular study

Journal of neurochemistry, 2011-02, Vol.116 (3), p.363-373

2011

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Tetracosahexaenoylethanolamide, a novel N-acylethanolamide, is elevated in ischemia and increases neuronal output

Journal of lipid research, 2020-11, Vol.61 (11), p.1480-1490

2020

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Whole body synthesis rates of DHA from α-linolenic acid are greater than brain DHA accretion and uptake rates in adult rats

Journal of lipid research, 2014-01, Vol.55 (1), p.62-74

2014

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Compound-specific isotope analysis resolves the dietary origin of docosahexaenoic acid in the mouse brain[S]

Journal of lipid research, 2017-10, Vol.58 (10), p.2071-2081

2017

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The low levels of eicosapentaenoic acid in rat brain phospholipids are maintained via multiple redundant mechanisms

Journal of lipid research, 2013-09, Vol.54 (9), p.2410-2422

2013

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Docosahexaenoic acid is both a product of and a precursor to tetracosahexaenoic acid in the rat[S]

Journal of lipid research, 2019-02, Vol.60 (2), p.412-420

2019

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Diffusion of docosahexaenoic and eicosapentaenoic acids through the blood–brain barrier: An in situ cerebral perfusion study

Neurochemistry international, 2009-12, Vol.55 (7), p.476-482

2009

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Dietary Long-Chain n-3 Polyunsaturated Fatty Acid Supplementation Alters Electrophysiological Properties in the Nucleus Accumbens and Emotional Behavior in Naïve and Chronically Stressed Mice

International journal of molecular sciences, 2022-06, Vol.23 (12), p.6650

2022

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The effects of n-6 polyunsaturated fatty acid deprivation on the inflammatory gene response to lipopolysaccharide in the mouse hippocampus

Journal of neuroinflammation, 2019-11, Vol.16 (1), p.237-237, Article 237

2019

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Anti-Inflammatory Effects of Omega-3 Fatty Acids in the Brain: Physiological Mechanisms and Relevance to Pharmacology

Updates to the n-3 polyunsaturated fatty acid biosynthesis pathway: DHA synthesis rates, tetracosahexaenoic acid and (minimal) retroconversion

Projected declines in global DHA availability for human consumption as a result of global warming

ACSL6 is critical for maintaining brain DHA levels

Polyunsaturated fatty acids and their metabolites in brain function and disease

Brain eicosapentaenoic acid metabolism as a lead for novel therapeutics in major depression

Novel 13C enrichment technique reveals early turnover of DHA in peripheral tissues

Do Eicosapentaenoic Acid and Docosahexaenoic Acid Have the Potential to Compete against Each Other?

Plasma non-esterified docosahexaenoic acid is the major pool supplying the brain

Turnover of brain DHA in mice is accurately determined by tracer-free natural abundance carbon isotope ratio analysis

Upregulated hepatic lipogenesis from dietary sugars in response to low palmitate feeding supplies brain palmitate

Effect of dietary docosahexaenoic acid (DHA) in phospholipids or triglycerides on brain DHA uptake and accretion

Dietary docosahexaenoic acid (DHA) downregulates liver DHA synthesis by inhibiting eicosapentaenoic acid elongation

Brain oxylipin concentrations following hypercapnia/ischemia: effects of brain dissection and dissection time[S]

Analysis of omega-3 and omega-6 polyunsaturated fatty acid metabolism by compound-specific isotope analysis in humans

Oleic acid‐bound FABP7 drives glioma cell proliferation through regulation of nuclear lipid droplet formation

Rapid de‐esterification and loss of eicosapentaenoic acid from rat brain phospholipids: an intracerebroventricular study

Tetracosahexaenoylethanolamide, a novel N-acylethanolamide, is elevated in ischemia and increases neuronal output

Whole body synthesis rates of DHA from α-linolenic acid are greater than brain DHA accretion and uptake rates in adult rats

Compound-specific isotope analysis resolves the dietary origin of docosahexaenoic acid in the mouse brain[S]

The low levels of eicosapentaenoic acid in rat brain phospholipids are maintained via multiple redundant mechanisms

Docosahexaenoic acid is both a product of and a precursor to tetracosahexaenoic acid in the rat[S]

Diffusion of docosahexaenoic and eicosapentaenoic acids through the blood–brain barrier: An in situ cerebral perfusion study

Dietary Long-Chain n-3 Polyunsaturated Fatty Acid Supplementation Alters Electrophysiological Properties in the Nucleus Accumbens and Emotional Behavior in Naïve and Chronically Stressed Mice

The effects of n-6 polyunsaturated fatty acid deprivation on the inflammatory gene response to lipopolysaccharide in the mouse hippocampus

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