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Ultrahigh-Throughput ESI-MS: Sampling Pushed to Six Samples per Second by Acoustic Ejection Mass Spectrometry

Analytical chemistry (Washington), 2020-09, Vol.92 (18), p.12242-12249

2020

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Advances in high‐throughput mass spectrometry in drug discovery

EMBO molecular medicine, 2023-01, Vol.15 (1), p.e14850-n/a

2023

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Allosteric Activation of Striatal-Enriched Protein Tyrosine Phosphatase (STEP, PTPN5) by a Fragment-like Molecule

Journal of medicinal chemistry, 2019-01, Vol.62 (1), p.306-316

2019

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Dichlorophenylpyridine-Based Molecules Inhibit Furin through an Induced-Fit Mechanism

ACS chemical biology, 2022-04, Vol.17 (4), p.816-821

2022

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Differential analyte derivatization enables unbiased MALDI-TOF-based high-throughput screening: A proof-of-concept study for the discovery of catechol-o-methyltransferase inhibitors

SLAS discovery, 2022-07, Vol.27 (5), p.287-297

2022

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MALDI-TOF-Based Affinity Selection Mass Spectrometry for Automated Screening of Protein–Ligand Interactions at High Throughput

SLAS discovery, 2021-01, Vol.26 (1), p.44-57

2021

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Automated MALDI Target Preparation Concept: Providing Ultra-High-Throughput Mass Spectrometry–Based Screening for Drug Discovery

SLAS technology, 2019-04, Vol.24 (2), p.209-221

2019

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Hit to Lead Account of the Discovery of Bisbenzamide and Related Ureidobenzamide Inhibitors of Rho Kinase

Journal of medicinal chemistry, 2010-01, Vol.53 (2), p.759-777

2010

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Substituted 2H-isoquinolin-1-one as potent Rho-Kinase inhibitors. Part 1: Hit-to-lead account

Bioorganic & medicinal chemistry letters, 2010-06, Vol.20 (11), p.3235-3239

2010

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Acoustic Ejection Mass Spectrometry: A Fully Automatable Technology for High-Throughput Screening in Drug Discovery

SLAS discovery, 2021-09, Vol.26 (8), p.961-973

2021

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MALDI-TOF Mass Spectrometry-Based High-Throughput Screening for Inhibitors of the Cytosolic DNA Sensor cGAS

SLAS discovery, 2020-04, Vol.25 (4), p.372-383

2020

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Establishing MALDI-TOF as Versatile Drug Discovery Readout to Dissect the PTP1B Enzymatic Reaction

SLAS discovery, 2018-07, Vol.23 (6), p.561-573

2018

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Label-free high-throughput screening via acoustic ejection mass spectrometry put into practice

SLAS discovery, 2023-07, Vol.28 (5), p.240-246

2023

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A small-molecule inhibitor of lectin-like oxidized LDL receptor-1 acts by stabilizing an inactive receptor tetramer state

Communications chemistry, 2020-06, Vol.3 (1), p.75-75, Article 75

2020

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Chemical Derivatization Enables MALDI-TOF-Based High-Throughput Screening for Microbial Trimethylamine (TMA)-Lyase Inhibitors

SLAS discovery, 2019-08, Vol.24 (7), p.766-777

2019

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Cleavage Site Specificity of Cathepsin K toward Cartilage Proteoglycans and Protease Complex Formation

Biological chemistry, 2003-06, Vol.384 (6), p.891-897

2003

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Cell-based assays for high-throughput screening

Expert opinion on drug discovery, 2006-09, Vol.1 (4), p.373-378

Büttner, Frank H

2006

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Miniaturisation of a high throughput screening assay comparing air displacement and capillary-based nanolitre transfer technologies

Combinatorial chemistry & high throughput screening, 2010-03, Vol.13 (3), p.229-241

2010

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Evaluation of the InteraX™ System Technology in a High-Throughput Screening Environment

Journal of biomolecular screening, 2005-08, Vol.10 (5), p.485-494

2005

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Miniaturization and Validation of a High-Throughput Serine Kinase Assay Using the Alpha Screen Platform

SLAS discovery, 2004-12, Vol.9 (8), p.719-725

2004

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Automated High Throughput Screening for Serine Kinase Inhibitors Using a LEADSeeker™ Scintillation Proximity Assay in the 1536-Well Format

SLAS discovery, 2002-02, Vol.7 (1), p.11-19

2002

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Cell-based assays for high-throughput screening: 23 - 25 May 2006, Pennsylvania Convention Center, Philadelphia, Pennsylvania, USA

Expert opinion on drug discovery, 2006-09, Vol.1 (4), p.373-378

Büttner, Frank H

2006

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Membrane type 1 matrix metalloproteinase (MT1-MMP) cleaves the recombinant aggrecan substrate rAgg1mut at the ‘aggrecanase’ and the MMP sites

Biochemical journal, 1998-07, Vol.333 (1), p.159-165

1998

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Discovery of olodaterol, a novel inhaled β2-adrenoceptor agonist with a 24h bronchodilatory efficacy

Bioorganic & medicinal chemistry letters, 2010-02, Vol.20 (4), p.1410-1414

2010

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Ultrahigh-Throughput ESI-MS: Sampling Pushed to Six Samples per Second by Acoustic Ejection Mass Spectrometry

Advances in high‐throughput mass spectrometry in drug discovery

Allosteric Activation of Striatal-Enriched Protein Tyrosine Phosphatase (STEP, PTPN5) by a Fragment-like Molecule

Dichlorophenylpyridine-Based Molecules Inhibit Furin through an Induced-Fit Mechanism

Differential analyte derivatization enables unbiased MALDI-TOF-based high-throughput screening: A proof-of-concept study for the discovery of catechol-o-methyltransferase inhibitors

MALDI-TOF-Based Affinity Selection Mass Spectrometry for Automated Screening of Protein–Ligand Interactions at High Throughput

Automated MALDI Target Preparation Concept: Providing Ultra-High-Throughput Mass Spectrometry–Based Screening for Drug Discovery

Hit to Lead Account of the Discovery of Bisbenzamide and Related Ureidobenzamide Inhibitors of Rho Kinase

Substituted 2H-isoquinolin-1-one as potent Rho-Kinase inhibitors. Part 1: Hit-to-lead account

Acoustic Ejection Mass Spectrometry: A Fully Automatable Technology for High-Throughput Screening in Drug Discovery

MALDI-TOF Mass Spectrometry-Based High-Throughput Screening for Inhibitors of the Cytosolic DNA Sensor cGAS

Establishing MALDI-TOF as Versatile Drug Discovery Readout to Dissect the PTP1B Enzymatic Reaction

Label-free high-throughput screening via acoustic ejection mass spectrometry put into practice

A small-molecule inhibitor of lectin-like oxidized LDL receptor-1 acts by stabilizing an inactive receptor tetramer state

Chemical Derivatization Enables MALDI-TOF-Based High-Throughput Screening for Microbial Trimethylamine (TMA)-Lyase Inhibitors

Cleavage Site Specificity of Cathepsin K toward Cartilage Proteoglycans and Protease Complex Formation

Cell-based assays for high-throughput screening

Miniaturisation of a high throughput screening assay comparing air displacement and capillary-based nanolitre transfer technologies

Evaluation of the InteraX™ System Technology in a High-Throughput Screening Environment

Miniaturization and Validation of a High-Throughput Serine Kinase Assay Using the Alpha Screen Platform

Automated High Throughput Screening for Serine Kinase Inhibitors Using a LEADSeeker™ Scintillation Proximity Assay in the 1536-Well Format

Cell-based assays for high-throughput screening: 23 - 25 May 2006, Pennsylvania Convention Center, Philadelphia, Pennsylvania, USA

Membrane type 1 matrix metalloproteinase (MT1-MMP) cleaves the recombinant aggrecan substrate rAgg1mut at the ‘aggrecanase’ and the MMP sites

Discovery of olodaterol, a novel inhaled β2-adrenoceptor agonist with a 24h bronchodilatory efficacy

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