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Structure and function of Parkin E3 ubiquitin ligase reveals aspects of RING and HECT ligases

Nature communications, 2013-06, Vol.4 (1), p.1982-1982, Article 1982

2013

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Modulation of nutrient sensing nuclear hormone receptors promotes weight loss through appetite suppression in mice

Diabetes, obesity & metabolism, 2010-03, Vol.12 (3), p.234-245

2010

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Distinct but Overlapping Epitopes for the Interaction of a CC-Chemokine with CCR1, CCR3, and CCR5

Biochemistry (Easton), 1997-08, Vol.36 (32), p.9642-9648

1997

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Transfer of a protein binding epitope to a minimal designed peptide

Biopolymers, 1998, Vol.47 (4), p.265-275

1998

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Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents

Journal of medicinal chemistry, 1997-10, Vol.40 (21), p.3359-3368

1997

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A family of phosphodiesterase inhibitors discovered by cocrystallography and scaffold-based drug design

Nature biotechnology, 2005-02, Vol.23 (2), p.201-207

2005

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A Glutamine Switch Mechanism for Nucleotide Selectivity by Phosphodiesterases

Molecular cell, 2004-07, Vol.15 (2), p.279-286

2004

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Structural Basis for the Activity of Drugs that Inhibit Phosphodiesterases

Structure (London), 2004-12, Vol.12 (12), p.2233-2247

2004

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Crystal Structures of Proto-oncogene Kinase Pim1: A Target of Aberrant Somatic Hypermutations in Diffuse Large Cell Lymphoma

Journal of molecular biology, 2005-04, Vol.348 (1), p.183-193

2005

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cA Glutamine Switch Mechanism for Nucleotide Selectivity by Phosphodiesterases

Molecular cell, 2004-07, Vol.15 (2), p.279-286

2004

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1,2-Bridged cyclopropenes

Journal of the American Chemical Society, 1991-10, Vol.113 (21), p.7969-7979

1991

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Differential Effect of Halide Anions on the Hydrolysis of Different Dansyl Substrates by Thermolysin

Biochemistry (Easton), 1994-05, Vol.33 (21), p.6516-6523

1994

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A Selective, Slow Binding Inhibitor of Factor VIIa Binds to a Nonstandard Active Site Conformation and Attenuates Thrombus Formation in Vivo

The Journal of biological chemistry, 2005-03, Vol.280 (10), p.9160-9169

2005

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Radical-based syntheses of 5-benzoyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid (ketorolac)

Canadian journal of chemistry, 1992-06, Vol.70 (6), p.1838-1842

1992

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N-(Triisopropylsilyl)pyrrole. A progenitor "par excellence" of 3-substituted pyrroles

Journal of organic chemistry, 1990-12, Vol.55 (26), p.6317-6328

1990

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Preclinical development of a novel inhibitor of oncogenic B-Raf

Journal of clinical oncology, 2006-06, Vol.24 (18_suppl), p.13056-13056

2006

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Oxidative Radical Cyclization of (.omega.-Iodoalkyl)indoles and Pyrroles. Synthesis of (-)-Monomorine and Three Diastereomers

Journal of organic chemistry, 1994-05, Vol.59 (9), p.2456-2466

1994

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Conformations of Thioamide-Containing Dipeptides: A Computational Study

Journal of the American Chemical Society, 1998-12, Vol.120 (47), p.12200-12206

1998

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Potent α4β1 Peptide Antagonists as Potential Anti-Inflammatory Agents

Journal of medicinal chemistry, 1997-10, Vol.40 (21), p.3359-3368

1997

Volltextzugriff (PDF)

Receptor-binding conformation of the "ELR" motif of IL-8: X-ray structure of the L5C/H33C variant at 2.35 Å resolution

Proteins, structure, function, and bioinformatics, 2000-03, Vol.38 (4), p.361-367

2000

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Structure-based design of six novel classes of nonpeptide antagonists of the bradykinin B2 receptor

Bioorganic & medicinal chemistry letters, 2000-11, Vol.10 (21), p.2421-2425

2000

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Stimulation of prostaglandin D2 receptors on human platelets by analogs of prostacyclin

Prostaglandins, 1991-08, Vol.42 (2), p.105-119

1991

Volltextzugriff (PDF)

Abbreviated Ibogaine Congeners. Synthesis and Reactions of Tropan-3-yl-2- and -3-indoles. Investigation of an Unusual Isomerization of 2-Substituted Indoles Using Computational and Spectroscopic Techniques

Journal of organic chemistry, 1994-04, Vol.59 (8), p.2164-2171

1994

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Structural change and receptor binding in a chemokine mutant with a rearranged disulfide: X-ray structure of E38C/C50AIL-8 at 2 A resolution

Proteins, structure, function, and bioinformatics, 1997-04, Vol.27 (4), p.556-566

1997

Volltextzugriff (PDF)

A Glutamine Switch Mechanism for Nucleotide Selectivity by Phosphodiesterases

Molecular cell, 2004-08, Vol.15 (4), p.659-659

2004

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Structure and function of Parkin E3 ubiquitin ligase reveals aspects of RING and HECT ligases

Modulation of nutrient sensing nuclear hormone receptors promotes weight loss through appetite suppression in mice

Distinct but Overlapping Epitopes for the Interaction of a CC-Chemokine with CCR1, CCR3, and CCR5

Transfer of a protein binding epitope to a minimal designed peptide

Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents

A family of phosphodiesterase inhibitors discovered by cocrystallography and scaffold-based drug design

A Glutamine Switch Mechanism for Nucleotide Selectivity by Phosphodiesterases

Structural Basis for the Activity of Drugs that Inhibit Phosphodiesterases

Crystal Structures of Proto-oncogene Kinase Pim1: A Target of Aberrant Somatic Hypermutations in Diffuse Large Cell Lymphoma

cA Glutamine Switch Mechanism for Nucleotide Selectivity by Phosphodiesterases

1,2-Bridged cyclopropenes

Differential Effect of Halide Anions on the Hydrolysis of Different Dansyl Substrates by Thermolysin

A Selective, Slow Binding Inhibitor of Factor VIIa Binds to a Nonstandard Active Site Conformation and Attenuates Thrombus Formation in Vivo

Radical-based syntheses of 5-benzoyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid (ketorolac)

N-(Triisopropylsilyl)pyrrole. A progenitor "par excellence" of 3-substituted pyrroles

Preclinical development of a novel inhibitor of oncogenic B-Raf

Oxidative Radical Cyclization of (.omega.-Iodoalkyl)indoles and Pyrroles. Synthesis of (-)-Monomorine and Three Diastereomers

Conformations of Thioamide-Containing Dipeptides: A Computational Study

Potent α4β1 Peptide Antagonists as Potential Anti-Inflammatory Agents

Receptor-binding conformation of the "ELR" motif of IL-8: X-ray structure of the L5C/H33C variant at 2.35 Å resolution

Structure-based design of six novel classes of nonpeptide antagonists of the bradykinin B2 receptor

Stimulation of prostaglandin D2 receptors on human platelets by analogs of prostacyclin

Abbreviated Ibogaine Congeners. Synthesis and Reactions of Tropan-3-yl-2- and -3-indoles. Investigation of an Unusual Isomerization of 2-Substituted Indoles Using Computational and Spectroscopic Techniques

Structural change and receptor binding in a chemokine mutant with a rearranged disulfide: X-ray structure of E38C/C50AIL-8 at 2 A resolution

A Glutamine Switch Mechanism for Nucleotide Selectivity by Phosphodiesterases

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