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Mechanism and disease association of E2-conjugating enzymes: lessons from UBE2T and UBE2L3

Biochemical journal, 2016-10, Vol.473 (20), p.3401-3419

2016

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Two Distinct Types of E3 Ligases Work in Unison to Regulate Substrate Ubiquitylation

Cell, 2016-08, Vol.166 (5), p.1198-1214.e24

2016

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The ubiquitin ligation machinery in the defense against bacterial pathogens

EMBO reports, 2021-11, Vol.22 (11), p.e52864-n/a

2021

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Structure of HHARI, a RING-IBR-RING Ubiquitin Ligase: Autoinhibition of an Ariadne-Family E3 and Insights into Ligation Mechanism

Structure (London), 2013-06, Vol.21 (6), p.1030-1041

2013

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Interconversion between Anticipatory and Active GID E3 Ubiquitin Ligase Conformations via Metabolically Driven Substrate Receptor Assembly

Molecular cell, 2020-01, Vol.77 (1), p.150-163.e9

2020

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CUL5-ARIH2 E3-E3 ubiquitin ligase structure reveals cullin-specific NEDD8 activation

Nature chemical biology, 2021-10, Vol.17 (10), p.1075-1083

2021

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GID E3 ligase supramolecular chelate assembly configures multipronged ubiquitin targeting of an oligomeric metabolic enzyme

Molecular cell, 2021-06, Vol.81 (11), p.2445-2459.e13

2021

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Catalysis of non-canonical protein ubiquitylation by the ARIH1 ubiquitin ligase

Biochemical journal, 2023-11, Vol.480 (22), p.1817-1831

2023

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TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexes

The EMBO journal, 2013-10, Vol.32 (21), p.2848-2860

2013

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Integrative proteomics reveals principles of dynamic phosphosignaling networks in human erythropoiesis

Molecular systems biology, 2020-12, Vol.16 (12), p.e9813-n/a

2020

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Skraban‐Deardorff intellectual disability syndrome‐associated mutations in WDR26 impair CTLH E3 complex assembly

FEBS letters, 2024-05, Vol.598 (9), p.978-994

2024

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Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase

Nature chemical biology, 2017-08, Vol.13 (8), p.850-857

2017

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The Fanconi anaemia components UBE2T and FANCM are functionally linked to nucleotide excision repair

PloS one, 2012-05, Vol.7 (5), p.e36970-e36970

2012

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Mechanistic Insight into Site-Restricted Monoubiquitination of FANCD2 by Ube2t, FANCL, and FANCI

Molecular cell, 2008-12, Vol.32 (6), p.767-777

2008

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Multisite phosphorylation dictates selective E2-E3 pairing as revealed by Ubc8/UBE2H-GID/CTLH assemblies

Molecular cell, 2024-01, Vol.84 (2), p.293-308.e14

2024

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Coupled monoubiquitylation of the co-E3 ligase DCNL1 by Ariadne-RBR E3 ubiquitin ligases promotes cullin-RING ligase complex remodeling

The Journal of biological chemistry, 2019-02, Vol.294 (8), p.2651-5314

2019

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E3 Ubiquitin Ligase HOIP Attenuates Apoptotic Cell Death Induced by Cisplatin

Cancer research (Chicago, Ill.), 2014-04, Vol.74 (8), p.2246-2257

2014

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Non-canonical substrate recognition by the human WDR26-CTLH E3 ligase regulates prodrug metabolism

Molecular cell, 2024-05, Vol.84 (10), p.1948-1963.e11

2024

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FBXO11-mediated proteolysis of BAHD1 relieves PRC2-dependent transcriptional repression in erythropoiesis

Blood, 2021-01, Vol.137 (2), p.155-167

2021

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ZOMES: the intriguing interplay of PCI complexes and the ubiquitin in protein homeostasis

Cell death & disease, 2017-08, Vol.8 (8), p.e3021-e3021

2017

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ARIH2 Is a Vif-Dependent Regulator of CUL5-Mediated APOBEC3G Degradation in HIV Infection

Cell host & microbe, 2019-07, Vol.26 (1), p.86-99.e7

2019

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Modular UBE2H-CTLH E2-E3 complexes regulate erythroid maturation

eLife, 2022-12, Vol.11

2022

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Loss of ubiquitin E2 Ube2w rescues hypersensitivity of Rnf4 mutant cells to DNA damage

Scientific reports, 2016-05, Vol.6 (1), p.26178-26178, Article 26178

2016

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C. elegans ring finger protein RNF-113 is involved in interstrand DNA crosslink repair and interacts with a RAD51C homolog

PloS one, 2013-03, Vol.8 (3), p.e60071-e60071

2013

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The Walker B motif in avian FANCM is required to limit sister chromatid exchanges but is dispensable for DNA crosslink repair

Nucleic acids research, 2009-07, Vol.37 (13), p.4360-4370

2009

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Mechanism and disease association of E2-conjugating enzymes: lessons from UBE2T and UBE2L3

Two Distinct Types of E3 Ligases Work in Unison to Regulate Substrate Ubiquitylation

The ubiquitin ligation machinery in the defense against bacterial pathogens

Structure of HHARI, a RING-IBR-RING Ubiquitin Ligase: Autoinhibition of an Ariadne-Family E3 and Insights into Ligation Mechanism

Interconversion between Anticipatory and Active GID E3 Ubiquitin Ligase Conformations via Metabolically Driven Substrate Receptor Assembly

CUL5-ARIH2 E3-E3 ubiquitin ligase structure reveals cullin-specific NEDD8 activation

GID E3 ligase supramolecular chelate assembly configures multipronged ubiquitin targeting of an oligomeric metabolic enzyme

Catalysis of non-canonical protein ubiquitylation by the ARIH1 ubiquitin ligase

TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexes

Integrative proteomics reveals principles of dynamic phosphosignaling networks in human erythropoiesis

Skraban‐Deardorff intellectual disability syndrome‐associated mutations in WDR26 impair CTLH E3 complex assembly

Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase

The Fanconi anaemia components UBE2T and FANCM are functionally linked to nucleotide excision repair

Mechanistic Insight into Site-Restricted Monoubiquitination of FANCD2 by Ube2t, FANCL, and FANCI

Multisite phosphorylation dictates selective E2-E3 pairing as revealed by Ubc8/UBE2H-GID/CTLH assemblies

Coupled monoubiquitylation of the co-E3 ligase DCNL1 by Ariadne-RBR E3 ubiquitin ligases promotes cullin-RING ligase complex remodeling

E3 Ubiquitin Ligase HOIP Attenuates Apoptotic Cell Death Induced by Cisplatin

Non-canonical substrate recognition by the human WDR26-CTLH E3 ligase regulates prodrug metabolism

FBXO11-mediated proteolysis of BAHD1 relieves PRC2-dependent transcriptional repression in erythropoiesis

ZOMES: the intriguing interplay of PCI complexes and the ubiquitin in protein homeostasis

ARIH2 Is a Vif-Dependent Regulator of CUL5-Mediated APOBEC3G Degradation in HIV Infection

Modular UBE2H-CTLH E2-E3 complexes regulate erythroid maturation

Loss of ubiquitin E2 Ube2w rescues hypersensitivity of Rnf4 mutant cells to DNA damage

C. elegans ring finger protein RNF-113 is involved in interstrand DNA crosslink repair and interacts with a RAD51C homolog

The Walker B motif in avian FANCM is required to limit sister chromatid exchanges but is dispensable for DNA crosslink repair

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