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Branched chain amino acid metabolism profiles in progressive human nonalcoholic fatty liver disease

Amino acids, 2015-03, Vol.47 (3), p.603-615

2015

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Decreased hepatotoxic bile acid composition and altered synthesis in progressive human nonalcoholic fatty liver disease

Toxicology and applied pharmacology, 2013-04, Vol.268 (2), p.132-140

2013

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Understanding and Controlling Sialylation in a CHO Fc-Fusion Process

PloS one, 2016-06, Vol.11 (6), p.e0157111-e0157111

2016

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Characterization of Hepatocellular Carcinoma Related Genes and Metabolites in Human Nonalcoholic Fatty Liver Disease

Digestive diseases and sciences, 2014-02, Vol.59 (2), p.365-374

2014

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Comparison of physiologic and pharmacologic parameters in Asian and mauritius cynomolgus macaques

Regulatory toxicology and pharmacology, 2015-10, Vol.73 (1), p.27-42

2015

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Identification of 1- and 3-methylhistidine as biomarkers of skeletal muscle toxicity by nuclear magnetic resonance-based metabolic profiling

Analytical biochemistry, 2011-03, Vol.410 (1), p.84-91

2011

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NMR-based metabolomics of mammalian cell and tissue cultures

Journal of biomolecular NMR, 2011-04, Vol.49 (3-4), p.195-206

2011

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Characterization of Organic Anion-Transporting Polypeptide (Oatp) 1a1 and 1a4 Null Mice Reveals Altered Transport Function and Urinary Metabolomic Profiles

Toxicological sciences, 2011-08, Vol.122 (2), p.587-597

2011

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Metabolomic analysis using optimized NMR and statistical methods

Analytical biochemistry, 2006-08, Vol.355 (1), p.62-70

2006

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Metabolomic and quality data for early and late passages of an antibody-producing industrial CHO cell line

Data in brief, 2020-12, Vol.33, p.106591-106591, Article 106591

2020

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Metabolomic and Transcriptomic Changes Induced by Overnight (16 h) Fasting in Male and Female Sprague−Dawley Rats

Chemical research in toxicology, 2011-04, Vol.24 (4), p.481-487

2011

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1H NMR-based lipidomics of rodent fur: species-specific lipid profiles and SCD1 inhibitor-related dermal toxicity[S]

Journal of lipid research, 2014-07, Vol.55 (7), p.1366-1374

2014

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Cannabinoid receptor antagonist-induced striated muscle toxicity and ethylmalonic-adipic aciduria in beagle dogs

Toxicological sciences, 2012-10, Vol.129 (2), p.268-279

2012

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Structural elucidation of human oxidative metabolites of muraglitazar: use of microbial bioreactors in the biosynthesis of metabolite standards

Drug metabolism and disposition, 2006-02, Vol.34 (2), p.267-280

2006

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Metabonomics classifies pathways affected by bioactive compounds. Artificial neural network classification of NMR spectra of plant extracts

Phytochemistry (Oxford), 2003-03, Vol.62 (6), p.971-985

2003

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Metabolomic profiling distinction of human nonalcoholic fatty liver disease progression from a common rat model

Obesity (Silver Spring, Md.), 2017-06, Vol.25 (6), p.1069-1076

2017

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New insights into genetic instability of an industrial CHO cell line by orthogonal omics

Biochemical engineering journal, 2020-12, Vol.164, p.107799, Article 107799

2020

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Structure–activity relationship study of central pyridine-derived TYK2 JH2 inhibitors: Optimization of the PK profile through C4′ and C6 variations

Bioorganic & medicinal chemistry letters, 2023-07, Vol.91, p.129373-129373, Article 129373

2023

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Identification of Imidazo[1,2‑b]pyridazine Derivatives as Potent, Selective, and Orally Active Tyk2 JH2 Inhibitors

ACS medicinal chemistry letters, 2019-03, Vol.10 (3), p.383-388

2019

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Increased MSX level improves biological productivity and production stability in multiple recombinant GS CHO cell lines

Engineering in life sciences, 2020-03, Vol.20 (3-4), p.112-125

2020

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NMR methods for metabolomics of mammalian cell culture bioreactors

Methods in molecular biology (Clifton, N.J.), 2014, Vol.1104, p.223

2014

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Small Molecule Antagonist of Leukocyte Function Associated Antigen-1 (LFA-1): Structure−Activity Relationships Leading to the Identification of 6-((5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)nicotinic Acid (BMS-688521)

Journal of medicinal chemistry, 2010-05, Vol.53 (9), p.3814-3830

2010

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Nuclear magnetic resonance metabonomics: methods for drug discovery and development

Methods in molecular biology (Clifton, N.J.), 2007, Vol.358, p.247

2007

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Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165

Branched chain amino acid metabolism profiles in progressive human nonalcoholic fatty liver disease

Decreased hepatotoxic bile acid composition and altered synthesis in progressive human nonalcoholic fatty liver disease

Understanding and Controlling Sialylation in a CHO Fc-Fusion Process

Characterization of Hepatocellular Carcinoma Related Genes and Metabolites in Human Nonalcoholic Fatty Liver Disease

Comparison of physiologic and pharmacologic parameters in Asian and mauritius cynomolgus macaques

Identification of 1- and 3-methylhistidine as biomarkers of skeletal muscle toxicity by nuclear magnetic resonance-based metabolic profiling

NMR-based metabolomics of mammalian cell and tissue cultures

Characterization of Organic Anion-Transporting Polypeptide (Oatp) 1a1 and 1a4 Null Mice Reveals Altered Transport Function and Urinary Metabolomic Profiles

Metabolomic analysis using optimized NMR and statistical methods

Metabolomic and quality data for early and late passages of an antibody-producing industrial CHO cell line

Metabolomic and Transcriptomic Changes Induced by Overnight (16 h) Fasting in Male and Female Sprague−Dawley Rats

1H NMR-based lipidomics of rodent fur: species-specific lipid profiles and SCD1 inhibitor-related dermal toxicity[S]

Cannabinoid receptor antagonist-induced striated muscle toxicity and ethylmalonic-adipic aciduria in beagle dogs

Structural elucidation of human oxidative metabolites of muraglitazar: use of microbial bioreactors in the biosynthesis of metabolite standards

Identification of N‑Methyl Nicotinamide and N‑Methyl Pyridazine-3-Carboxamide Pseudokinase Domain Ligands as Highly Selective Allosteric Inhibitors of Tyrosine Kinase 2 (TYK2)

Metabonomics classifies pathways affected by bioactive compounds. Artificial neural network classification of NMR spectra of plant extracts

Metabolomic profiling distinction of human nonalcoholic fatty liver disease progression from a common rat model

New insights into genetic instability of an industrial CHO cell line by orthogonal omics

Structure–activity relationship study of central pyridine-derived TYK2 JH2 inhibitors: Optimization of the PK profile through C4′ and C6 variations

Identification of Imidazo[1,2‑b]pyridazine Derivatives as Potent, Selective, and Orally Active Tyk2 JH2 Inhibitors

Increased MSX level improves biological productivity and production stability in multiple recombinant GS CHO cell lines

NMR methods for metabolomics of mammalian cell culture bioreactors

Small Molecule Antagonist of Leukocyte Function Associated Antigen-1 (LFA-1): Structure−Activity Relationships Leading to the Identification of 6-((5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)nicotinic Acid (BMS-688521)

Nuclear magnetic resonance metabonomics: methods for drug discovery and development

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