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Managing the TME to improve the efficacy of cancer therapy

Frontiers in immunology, 2022-10, Vol.13, p.954992-954992

2022

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Immunotoxins: the role of the toxin

Toxins, 2013-08, Vol.5 (8), p.1486-1502

2013

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How do Bax and Bak lead to permeabilization of the outer mitochondrial membrane?

Current opinion in cell biology, 2006-12, Vol.18 (6), p.685-689

2006

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Antibody drug conjugates, targeting cancer-expressed EGFR, exhibit potent and specific antitumor activity

Biomedicine & pharmacotherapy, 2023-01, Vol.157, p.114047-114047, Article 114047

2023

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Targeting Receptors on Cancer Cells with Protein Toxins

Biomolecules (Basel, Switzerland), 2020-09, Vol.10 (9), p.1331

2020

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Chemical Screens Identify Drugs that Enhance or Mitigate Cellular Responses to Antibody-Toxin Fusion Proteins

PloS one, 2016-08, Vol.11 (8), p.e0161415

2016

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Bax Activates Endophilin B1 Oligomerization and Lipid Membrane Vesiculation

The Journal of biological chemistry, 2009-12, Vol.284 (49), p.34390-34399

2009

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Abstract A018: Synergy between IAP inhibitors and a cytotoxic antibody-based chimeric protein in pancreatic cancer cells

Molecular cancer therapeutics, 2019-12, Vol.18 (12_Supplement), p.A018-A018

2019

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Endosome fusion induced by diphtheria toxin translocation domain

Proceedings of the National Academy of Sciences - PNAS, 2008-06, Vol.105 (23), p.8020-8025

2008

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The Cytokine, Granulocyte-Macrophage Colony-stimulating Factor (GM-CSF), Can Deliver Bcl-XL as an Extracellular Fusion Protein to Protect Cells from Apoptosis and Retain Differentiation Induction

The Journal of biological chemistry, 2007-04, Vol.282 (15), p.11246-11254

2007

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Proteolytic Cleavage of a C-terminal Prosequence, Leading to Autoprocessing at the N Terminus, Activates Leucine Aminopeptidase from Pseudomonas aeruginosa

The Journal of biological chemistry, 2009-04, Vol.284 (15), p.10243-10253

2009

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Birinapant selectively enhances immunotoxin‐mediated killing of cancer cells conditional on the IAP protein levels within target cells

The FASEB journal, 2023-12, Vol.37 (12), p.e23292-n/a

2023

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Targeting a Cancer-Specific Epitope of the Epidermal Growth Factor Receptor in Triple-Negative Breast Cancer

JNCI : Journal of the National Cancer Institute, 2016-08, Vol.108 (8), p.djw028

2016

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Abstract B099: Characterization of monoclonal antibodies generated to the 287-302 amino acid loop of the human epidermal growth factor receptor

Molecular cancer therapeutics, 2019-12, Vol.18 (12_Supplement), p.B099-B099

2019

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ABT-737 promotes the dislocation of ER luminal proteins to the cytosol, including pseudomonas exotoxin

Molecular cancer therapeutics, 2014-06, Vol.13 (6), p.1655-1663

2014

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Abstract 1653: Toward developing a humanized mouse model of the microenvironment associated with the malignant cells of Hodgkin lymphoma

Cancer research (Chicago, Ill.), 2022-06, Vol.82 (12_Supplement), p.1653-1653

2022

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Conformation of BCL-XL upon Membrane Integration

Journal of molecular biology, 2015-07, Vol.427 (13), p.2262-2270

2015

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Abstract 3023: The antitumor activity of immunotoxins is enhanced by tofacitinib

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.3023-3023

2017

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Abstract 556: Bystander effects of EGFR-targeting 40H3 antibody-drug conjugates in glioblastoma with heterogeneous EGFR expression

Cancer research (Chicago, Ill.), 2023-04, Vol.83 (7_Supplement), p.556-556

2023

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Tofacitinib enhances delivery of antibody-based therapeutics to tumor cells through modulation of inflammatory cells

JCI insight, 2019-03, Vol.4 (5)

2019

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Characterization of the membrane-inserted C-terminus of cytoprotective BCL-XL

Protein expression and purification, 2016-06, Vol.122, p.56-63

2016

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Characterization of monoclonal antibodies generated to the 287-302 amino acid loop of the human epidermal growth factor receptor

Antibody therapeutics, 2019-10, Vol.2 (4), p.88-98

2019

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Engineering the Refolding Pathway and the Quaternary Structure of Seminal Ribonuclease by Newly Introduced Disulfide Bridges

The Journal of biological chemistry, 2002-12, Vol.277 (50), p.48643-48649

2002

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Abstract 5482: Combining the anti-mesothelin immunotoxin SS1P with the BH3-mimetic ABT-737 induces cell death in SS1P-resistant pancreatic cancer cell lines

Cancer research (Chicago, Ill.), 2013-04, Vol.73 (8_Supplement), p.5482-5482

2013

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Combining the antimesothelin immunotoxin SS1P with the BH3-mimetic ABT-737 induces cell death in SS1P-resistant pancreatic cancer cells

Journal of immunotherapy (1997), 2014-01, Vol.37 (1), p.8

2014

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Managing the TME to improve the efficacy of cancer therapy

Immunotoxins: the role of the toxin

How do Bax and Bak lead to permeabilization of the outer mitochondrial membrane?

Antibody drug conjugates, targeting cancer-expressed EGFR, exhibit potent and specific antitumor activity

Targeting Receptors on Cancer Cells with Protein Toxins

Chemical Screens Identify Drugs that Enhance or Mitigate Cellular Responses to Antibody-Toxin Fusion Proteins

Bax Activates Endophilin B1 Oligomerization and Lipid Membrane Vesiculation

Abstract A018: Synergy between IAP inhibitors and a cytotoxic antibody-based chimeric protein in pancreatic cancer cells

Endosome fusion induced by diphtheria toxin translocation domain

The Cytokine, Granulocyte-Macrophage Colony-stimulating Factor (GM-CSF), Can Deliver Bcl-XL as an Extracellular Fusion Protein to Protect Cells from Apoptosis and Retain Differentiation Induction

Proteolytic Cleavage of a C-terminal Prosequence, Leading to Autoprocessing at the N Terminus, Activates Leucine Aminopeptidase from Pseudomonas aeruginosa

Birinapant selectively enhances immunotoxin‐mediated killing of cancer cells conditional on the IAP protein levels within target cells

Targeting a Cancer-Specific Epitope of the Epidermal Growth Factor Receptor in Triple-Negative Breast Cancer

Abstract B099: Characterization of monoclonal antibodies generated to the 287-302 amino acid loop of the human epidermal growth factor receptor

ABT-737 promotes the dislocation of ER luminal proteins to the cytosol, including pseudomonas exotoxin

Abstract 1653: Toward developing a humanized mouse model of the microenvironment associated with the malignant cells of Hodgkin lymphoma

Conformation of BCL-XL upon Membrane Integration

Abstract 3023: The antitumor activity of immunotoxins is enhanced by tofacitinib

Abstract 556: Bystander effects of EGFR-targeting 40H3 antibody-drug conjugates in glioblastoma with heterogeneous EGFR expression

Tofacitinib enhances delivery of antibody-based therapeutics to tumor cells through modulation of inflammatory cells

Characterization of the membrane-inserted C-terminus of cytoprotective BCL-XL

Characterization of monoclonal antibodies generated to the 287-302 amino acid loop of the human epidermal growth factor receptor

Engineering the Refolding Pathway and the Quaternary Structure of Seminal Ribonuclease by Newly Introduced Disulfide Bridges

Abstract 5482: Combining the anti-mesothelin immunotoxin SS1P with the BH3-mimetic ABT-737 induces cell death in SS1P-resistant pancreatic cancer cell lines

Combining the antimesothelin immunotoxin SS1P with the BH3-mimetic ABT-737 induces cell death in SS1P-resistant pancreatic cancer cells

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