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Experimental in vitro and in vivo models for the study of human hepatitis B virus infection

Journal of hepatology, 2016-04, Vol.64 (1), p.S17-S31

2016

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Multiorgan and Renal Tropism of SARS-CoV-2

The New England journal of medicine, 2020-08, Vol.383 (6), p.590-592

2020

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Human liver chimeric mice as a new model of chronic hepatitis E virus infection and preclinical drug evaluation

Journal of hepatology, 2016-05, Vol.64 (5), p.1033-1040

2016

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Hepatitis Delta co-infection in humanized mice leads to pronounced induction of innate immune responses in comparison to HBV mono-infection

Journal of hepatology, 2015-08, Vol.63 (2), p.346-353

2015

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Humanized chimeric uPA mouse model for the study of hepatitis B and D virus interactions and preclinical drug evaluation

Hepatology (Baltimore, Md.), 2012-03, Vol.55 (3), p.685-694

2012

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Hepatitis B Virus Particles Activate Toll‐Like Receptor 2 Signaling Initially Upon Infection of Primary Human Hepatocytes

Hepatology (Baltimore, Md.), 2020-09, Vol.72 (3), p.829-844

2020

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Binding of hepatitis B virus to its cellular receptor alters the expression profile of genes of bile acid metabolism

Hepatology (Baltimore, Md.), 2014-11, Vol.60 (5), p.1483-1493

2014

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Multiscale modeling of HBV infection integrating intra- and intercellular viral propagation to analyze extracellular viral markers

PLoS computational biology, 2024-03, Vol.20 (3), p.e1011238-e1011238

2024

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Both interferon alpha and lambda can reduce all intrahepatic HDV infection markers in HBV/HDV infected humanized mice

Scientific reports, 2017-06, Vol.7 (1), p.3757-11, Article 3757

2017

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The Role of cccDNA in HBV Maintenance

Viruses, 2017-06, Vol.9 (6), p.156

2017

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Down-regulation of cell membrane localized NTCP expression in proliferating hepatocytes prevents hepatitis B virus infection

Emerging microbes & infections, 2019-01, Vol.8 (1), p.879-894

2019

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Strong Replication Interference Between Hepatitis Delta Viruses in Human Liver Chimeric Mice

Frontiers in microbiology, 2021-07, Vol.12, p.671466-671466

2021

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Strain-specific responsiveness of hepatitis D virus to interferon-alpha treatment

JHEP reports, 2023-04, Vol.5 (4), p.100673-100673, Article 100673

2023

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Serum HBV pgRNA as a clinical marker for cccDNA activity

Journal of hepatology, 2017-02, Vol.66 (2), p.460-462

2017

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Neuropathology of patients with COVID-19 in Germany: a post-mortem case series

Lancet neurology, 2020-11, Vol.19 (11), p.919-929

2020

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IFN-α inhibits HBV transcription and replication in cell culture and in humanized mice by targeting the epigenetic regulation of the nuclear cccDNA minichromosome

The Journal of clinical investigation, 2012-02, Vol.122 (2), p.529-537

2012

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Specificity protein 2 (Sp2) is essential for mouse development and autonomous proliferation of mouse embryonic fibroblasts

PloS one, 2010-03, Vol.5 (3), p.e9587-e9587

2010

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Lymphocytes transiently expressing virus-specific T cell receptors reduce hepatitis B virus infection

The Journal of clinical investigation, 2017-08, Vol.127 (8), p.3177-3188

2017

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SAT-342-YI PegIFNα treatment in NUC-suppressed HBV/HDV-infected mice with high numbers of HDV-monoinfected cells reduces HDV infection below the limit of quantification

Journal of hepatology, 2024-06, Vol.80, p.S733-S733

2024

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Efficacy of NVR 3-778, Alone and In Combination With Pegylated Interferon, vs Entecavir In uPA/SCID Mice With Humanized Livers and HBV Infection

Gastroenterology (New York, N.Y. 1943), 2018-02, Vol.154 (3), p.652-662.e8

2018

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FRI-227 - HBs-directed T cell engager antibodies foster efficient recruitment of T cells and lead to strong reduction of hepatitis B virus infection in livers of human liver chimeric mice

Journal of hepatology, 2023-06, Vol.78, p.S1023-S1024

2023

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HBs-directed T cell engager antibodies foster efficient recruitment of T cells and lead to strong reduction of hepatitis B virus infection in livers of human liver chimeric mice

Journal of hepatology, 2023-06, Vol.78, p.S1023-S1024

2023

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Chromatin Extraction from Frozen Chimeric Liver Tissue for Chromatin Immunoprecipitation Analysis

Journal of visualized experiments, 2021-03 (169)

2021

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Therapeutic suppression of HBV transcripts promotes reappearance of the SMC5/6 complex and cccDNA silencing in vivo without affecting posttranslational modifications of cccDNA-bound histones

Journal of hepatology, 2022-07, Vol.77, p.S256

2022

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Therapeutic shutdown of HBV transcripts promotes reappearance of the SMC5/6 complex and silencing of the viral genome in vivo

Gut, 2022-02, Vol.71 (2), p.372

2022

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Experimental in vitro and in vivo models for the study of human hepatitis B virus infection

Multiorgan and Renal Tropism of SARS-CoV-2

Human liver chimeric mice as a new model of chronic hepatitis E virus infection and preclinical drug evaluation

Hepatitis Delta co-infection in humanized mice leads to pronounced induction of innate immune responses in comparison to HBV mono-infection

Humanized chimeric uPA mouse model for the study of hepatitis B and D virus interactions and preclinical drug evaluation

Hepatitis B Virus Particles Activate Toll‐Like Receptor 2 Signaling Initially Upon Infection of Primary Human Hepatocytes

Binding of hepatitis B virus to its cellular receptor alters the expression profile of genes of bile acid metabolism

Multiscale modeling of HBV infection integrating intra- and intercellular viral propagation to analyze extracellular viral markers

Both interferon alpha and lambda can reduce all intrahepatic HDV infection markers in HBV/HDV infected humanized mice

The Role of cccDNA in HBV Maintenance

Down-regulation of cell membrane localized NTCP expression in proliferating hepatocytes prevents hepatitis B virus infection

Strong Replication Interference Between Hepatitis Delta Viruses in Human Liver Chimeric Mice

Strain-specific responsiveness of hepatitis D virus to interferon-alpha treatment

Serum HBV pgRNA as a clinical marker for cccDNA activity

Neuropathology of patients with COVID-19 in Germany: a post-mortem case series

IFN-α inhibits HBV transcription and replication in cell culture and in humanized mice by targeting the epigenetic regulation of the nuclear cccDNA minichromosome

Specificity protein 2 (Sp2) is essential for mouse development and autonomous proliferation of mouse embryonic fibroblasts

Lymphocytes transiently expressing virus-specific T cell receptors reduce hepatitis B virus infection

SAT-342-YI PegIFNα treatment in NUC-suppressed HBV/HDV-infected mice with high numbers of HDV-monoinfected cells reduces HDV infection below the limit of quantification

Efficacy of NVR 3-778, Alone and In Combination With Pegylated Interferon, vs Entecavir In uPA/SCID Mice With Humanized Livers and HBV Infection

FRI-227 - HBs-directed T cell engager antibodies foster efficient recruitment of T cells and lead to strong reduction of hepatitis B virus infection in livers of human liver chimeric mice

HBs-directed T cell engager antibodies foster efficient recruitment of T cells and lead to strong reduction of hepatitis B virus infection in livers of human liver chimeric mice

Chromatin Extraction from Frozen Chimeric Liver Tissue for Chromatin Immunoprecipitation Analysis

Therapeutic suppression of HBV transcripts promotes reappearance of the SMC5/6 complex and cccDNA silencing in vivo without affecting posttranslational modifications of cccDNA-bound histones

Therapeutic shutdown of HBV transcripts promotes reappearance of the SMC5/6 complex and silencing of the viral genome in vivo

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