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Mechanism of β2AR regulation by an intracellular positive allosteric modulator

Science (American Association for the Advancement of Science), 2019-06, Vol.364 (6447), p.1283-1287

2019

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Multiple ligand-specific conformations of the β2-adrenergic receptor

Nature chemical biology, 2011-08, Vol.7 (10), p.692-700

2011

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Loss of biased signaling at a G protein-coupled receptor in overexpressed systems

PloS one, 2023-03, Vol.18 (3), p.e0283477-e0283477

2023

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Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation

Nature (London), 2016-07, Vol.535 (7612), p.448-452

2016

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Manifold roles of β-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9

Science signaling, 2018-09, Vol.11 (549)

2018

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β-Arrestin- but Not G Protein-Mediated Signaling by the "Decoy" Receptor CXCR7

Proceedings of the National Academy of Sciences - PNAS, 2010-01, Vol.107 (2), p.628-632

2010

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unique mechanism of β-blocker action: Carvedilol stimulates β-arrestin signaling

Proceedings of the National Academy of Sciences - PNAS, 2007-10, Vol.104 (42), p.16657-16662

2007

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Allosteric modulator potentiates β2AR agonist-promoted bronchoprotection in asthma models

The Journal of clinical investigation, 2023-09, Vol.133 (18), p.1-13

2023

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Allosteric “beta-blocker” isolated from a DNA-encoded small molecule library

Proceedings of the National Academy of Sciences - PNAS, 2017-02, Vol.114 (7), p.1708-1713

2017

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How carvedilol does not activate β2-adrenoceptors

Nature communications, 2023-11, Vol.14 (1), p.7866-7866, Article 7866

2023

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β-Arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2

Proceedings of the National Academy of Sciences - PNAS, 2009-04, Vol.106 (16), p.6650-6655

2009

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Different G Protein-Coupled Receptor Kinases Govern G Protein and β-Arrestin-Mediated Signaling of V2 Vasopressin Receptor

Proceedings of the National Academy of Sciences - PNAS, 2005-02, Vol.102 (5), p.1448-1453

2005

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Functional Antagonism of Different G Protein-Coupled Receptor Kinases for β-Arrestin-Mediated Angiotensin II Receptor Signaling

Proceedings of the National Academy of Sciences - PNAS, 2005-02, Vol.102 (5), p.1442-1447

2005

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Independent β-Arrestin 2 and G Protein-Mediated Pathways for Angiotensin II Activation of Extracellular Signal-Regulated Kinases 1 and 2

Proceedings of the National Academy of Sciences - PNAS, 2003-09, Vol.100 (19), p.10782-10787

2003

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Src-mediated Tyrosine Phosphorylation of Dynamin Is Required for β2-Adrenergic Receptor Internalization and Mitogen-activated Protein Kinase Signaling

The Journal of biological chemistry, 1999-01, Vol.274 (3), p.1185-1188

1999

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Desensitization, Internalization, and Signaling Functions of β-Arrestins Demonstrated by RNA Interference

Proceedings of the National Academy of Sciences - PNAS, 2003-02, Vol.100 (4), p.1740-1744

2003

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Mechanism of intracellular allosteric β2AR antagonist revealed by X-ray crystal structure

Nature (London), 2017-08, Vol.548 (7668), p.480-484

2017

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Discovery of β2 Adrenergic Receptor Ligands Using Biosensor Fragment Screening of Tagged Wild-Type Receptor

ACS medicinal chemistry letters, 2013-10, Vol.4 (10), p.1005-1010

2013

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Essential Role for G Protein-coupled Receptor Endocytosis in the Activation of Mitogen-activated Protein Kinase

The Journal of biological chemistry, 1998-01, Vol.273 (2), p.685-688

1998

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Conformationally selective RNA aptamers allosterically modulate the β2-adrenoceptor

Nature chemical biology, 2016-07, Vol.12 (9), p.709-716

2016

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Molecular Mechanism of β-Arrestin-Biased Agonism at Seven-Transmembrane Receptors

Annual review of pharmacology and toxicology, 2012-01, Vol.52 (1), p.179-197

2012

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Src-dependent Tyrosine Phosphorylation Regulates Dynamin Self-assembly and Ligand-induced Endocytosis of the Epidermal Growth Factor Receptor

The Journal of biological chemistry, 2002-07, Vol.277 (29), p.26642-26651

2002

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SnapShot: β-Arrestin Functions

Cell, 2020-09, Vol.182 (5), p.1362-1362.e1

2020

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Distinct Phosphorylation Sites on the β 2 -Adrenergic Receptor Establish a Barcode That Encodes Differential Functions of β-Arrestin

Science signaling, 2011-08, Vol.4 (185)

2011

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Loss of Biased Signaling Specificity of the Angiotensin II Type 1 Receptor in Overexpressed Systems

The FASEB journal, 2022-05, Vol.36 (S1), p.n/a

2022

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Mechanism of β2AR regulation by an intracellular positive allosteric modulator

Multiple ligand-specific conformations of the β2-adrenergic receptor

Loss of biased signaling at a G protein-coupled receptor in overexpressed systems

Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation

Manifold roles of β-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9

β-Arrestin- but Not G Protein-Mediated Signaling by the "Decoy" Receptor CXCR7

unique mechanism of β-blocker action: Carvedilol stimulates β-arrestin signaling

Allosteric modulator potentiates β2AR agonist-promoted bronchoprotection in asthma models

Allosteric “beta-blocker” isolated from a DNA-encoded small molecule library

How carvedilol does not activate β2-adrenoceptors

β-Arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2

Different G Protein-Coupled Receptor Kinases Govern G Protein and β-Arrestin-Mediated Signaling of V2 Vasopressin Receptor

Functional Antagonism of Different G Protein-Coupled Receptor Kinases for β-Arrestin-Mediated Angiotensin II Receptor Signaling

Independent β-Arrestin 2 and G Protein-Mediated Pathways for Angiotensin II Activation of Extracellular Signal-Regulated Kinases 1 and 2

Src-mediated Tyrosine Phosphorylation of Dynamin Is Required for β2-Adrenergic Receptor Internalization and Mitogen-activated Protein Kinase Signaling

Desensitization, Internalization, and Signaling Functions of β-Arrestins Demonstrated by RNA Interference

Mechanism of intracellular allosteric β2AR antagonist revealed by X-ray crystal structure

Discovery of β2 Adrenergic Receptor Ligands Using Biosensor Fragment Screening of Tagged Wild-Type Receptor

Essential Role for G Protein-coupled Receptor Endocytosis in the Activation of Mitogen-activated Protein Kinase

Conformationally selective RNA aptamers allosterically modulate the β2-adrenoceptor

Molecular Mechanism of β-Arrestin-Biased Agonism at Seven-Transmembrane Receptors

Src-dependent Tyrosine Phosphorylation Regulates Dynamin Self-assembly and Ligand-induced Endocytosis of the Epidermal Growth Factor Receptor

SnapShot: β-Arrestin Functions

Distinct Phosphorylation Sites on the β 2 -Adrenergic Receptor Establish a Barcode That Encodes Differential Functions of β-Arrestin

Loss of Biased Signaling Specificity of the Angiotensin II Type 1 Receptor in Overexpressed Systems

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