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Mus81-mediated DNA cleavage resolves replication forks stalled by topoisomerase I-DNA complexes

The Journal of cell biology, 2011-11, Vol.195 (5), p.739-749

2011

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Poly(ADP-ribose) polymerase and XPF-ERCC1 participate in distinct pathways for the repair of topoisomerase I-induced DNA damage in mammalian cells

Nucleic acids research, 2011-05, Vol.39 (9), p.3607

2011

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2-Arylquinolines as novel anticancer agents with dual EGFR/FAK kinase inhibitory activity: synthesis, biological evaluation, and molecular modelling insights

Journal of enzyme inhibition and medicinal chemistry, 2022-12, Vol.37 (1), p.355-378

2022

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Novel Indenoisoquinolines NSC 725776 and NSC 724998 Produce Persistent Topoisomerase I Cleavage Complexes and Overcome Multidrug Resistance

Cancer research (Chicago, Ill.), 2007-11, Vol.67 (21), p.10397-10405

2007

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Targeting tumor cells expressing p53 with a water-soluble inhibitor of Hdm2

Molecular cancer therapeutics, 2008-08, Vol.7 (8), p.2445-2454

2008

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Discovery of 4-alkoxy-2-aryl-6,7-dimethoxyquinolines as a new class of topoisomerase I inhibitors endowed with potent in vitro anticancer activity

European journal of medicinal chemistry, 2021-04, Vol.215, p.113261-113261, Article 113261

2021

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TOP1-DNA Trapping by Exatecan and Combination Therapy with ATR Inhibitor

Molecular cancer therapeutics, 2022-07, Vol.21 (7), p.1090-1102

2022

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Bisindenoisoquinoline Bis-1,3-{(5,6-dihydro-5,11-diketo-11H-indeno[1,2-c]isoquinoline)-6-propylamino}propane bis(trifluoroacetate) (NSC 727357), a DNA Intercalator and Topoisomerase Inhibitor with Antitumor Activity

Molecular pharmacology, 2006-09, Vol.70 (3), p.1109-1120

2006

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Novel high-throughput electrochemiluminescent assay for identification of human tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors and characterization of furamidine (NSC 305831) as an inhibitor of Tdp1

Nucleic acids research, 2007-07, Vol.35 (13), p.4474

2007

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The Iron Chelator Dp44mT Causes DNA Damage and Selective Inhibition of Topoisomerase IIα in Breast Cancer Cells

Cancer research (Chicago, Ill.), 2009-02, Vol.69 (3), p.948-957

2009

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The Iron Chelator Dp44mT Causes DNA Damage and Selective Inhibition of Topoisomerase Ilα in Breast Cancer Cells

Cancer research (Chicago, Ill.), 2009, Vol.69 (3), p.948-957

2009

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The iron chelator Dp44mT causes DNA damage and selective inhibition of topoisomerase IIalpha in breast cancer cells

Cancer research (Chicago, Ill.), 2009-02, Vol.69 (3), p.948

2009

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Region of cauliflower mosaic virus gene VI involved in resistance -breakage

Agama, Keli K

2001

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Hereditary ataxia SCAN1 cells are defective for the repair of transcription-dependent topoisomerase I cleavage complexes

DNA repair, 2006-12, Vol.5 (12), p.1489-1494

2006

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Synthesis and Biological Evaluation of Indenoisoquinolines That Inhibit Both Tyrosyl-DNA Phosphodiesterase I (Tdp1) and Topoisomerase I (Top1)

Journal of medicinal chemistry, 2013-01, Vol.56 (1), p.182-200

2013

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Cellular Topoisomerase I Inhibition and Antiproliferative Activity by MJ-III-65 (NSC 706744), an Indenoisoquinoline Topoisomerase I Poison

Molecular pharmacology, 2005-02, Vol.67 (2), p.523-530

2005

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Cauliflower mosaic virus gene VI product N-terminus contains regions involved in resistance-breakage, self-association and interactions with movement protein

Virus research, 2008-12, Vol.138 (1), p.119-129

2008

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Total Synthesis of Luotonin and a Small Library of AB-Ring Substituted Analogues by Cascade Radical Annulation of Isonitriles

Synlett, 2005-11, Vol.2005 (18), p.2843-2846

2005

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Synthesis and biological assays of E-ring analogs of camptothecin and homocamptothecin

Bioorganic & medicinal chemistry, 2006-09, Vol.14 (18), p.6202-6212

2006

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Effects of geldanamycin on hatching and juvenile motility in Caenorhabditis elegans and Heterodera glycines

Journal of chemical ecology, 2005-10, Vol.31 (10), p.2481-2491

2005

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Anti-tumor drug candidate 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole induces single-strand breaks and DNA-protein cross-links in sensitive MCF-7 breast cancer cells

Cancer chemotherapy and pharmacology, 2006-07, Vol.58 (1), p.62-72

2006

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Total and semisynthesis and in vitro studies of both enantiomers of 20-fluorocamptothecin

Bioorganic & medicinal chemistry letters, 2005-11, Vol.15 (21), p.4736-4740

2005

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Repair of Topoisomerase I‐Mediated DNA Damage

Progress in Nucleic Acid Research and Molecular Biology, 2006, Vol.81, p.179-229

2006

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Mus81-mediated DNA cleavage resolves replication forks stalled by topoisomerase I-DNA complexes

Poly(ADP-ribose) polymerase and XPF-ERCC1 participate in distinct pathways for the repair of topoisomerase I-induced DNA damage in mammalian cells

2-Arylquinolines as novel anticancer agents with dual EGFR/FAK kinase inhibitory activity: synthesis, biological evaluation, and molecular modelling insights

Novel Indenoisoquinolines NSC 725776 and NSC 724998 Produce Persistent Topoisomerase I Cleavage Complexes and Overcome Multidrug Resistance

Targeting tumor cells expressing p53 with a water-soluble inhibitor of Hdm2

Discovery of 4-alkoxy-2-aryl-6,7-dimethoxyquinolines as a new class of topoisomerase I inhibitors endowed with potent in vitro anticancer activity

TOP1-DNA Trapping by Exatecan and Combination Therapy with ATR Inhibitor

Bisindenoisoquinoline Bis-1,3-{(5,6-dihydro-5,11-diketo-11H-indeno[1,2-c]isoquinoline)-6-propylamino}propane bis(trifluoroacetate) (NSC 727357), a DNA Intercalator and Topoisomerase Inhibitor with Antitumor Activity

Novel high-throughput electrochemiluminescent assay for identification of human tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors and characterization of furamidine (NSC 305831) as an inhibitor of Tdp1

The Iron Chelator Dp44mT Causes DNA Damage and Selective Inhibition of Topoisomerase IIα in Breast Cancer Cells

The Iron Chelator Dp44mT Causes DNA Damage and Selective Inhibition of Topoisomerase Ilα in Breast Cancer Cells

The iron chelator Dp44mT causes DNA damage and selective inhibition of topoisomerase IIalpha in breast cancer cells

Region of cauliflower mosaic virus gene VI involved in resistance -breakage

Hereditary ataxia SCAN1 cells are defective for the repair of transcription-dependent topoisomerase I cleavage complexes

Synthesis and Biological Evaluation of Indenoisoquinolines That Inhibit Both Tyrosyl-DNA Phosphodiesterase I (Tdp1) and Topoisomerase I (Top1)

Cellular Topoisomerase I Inhibition and Antiproliferative Activity by MJ-III-65 (NSC 706744), an Indenoisoquinoline Topoisomerase I Poison

Cauliflower mosaic virus gene VI product N-terminus contains regions involved in resistance-breakage, self-association and interactions with movement protein

Total Synthesis of Luotonin and a Small Library of AB-Ring Substituted Analogues by Cascade Radical Annulation of Isonitriles

Synthesis and biological assays of E-ring analogs of camptothecin and homocamptothecin

Effects of geldanamycin on hatching and juvenile motility in Caenorhabditis elegans and Heterodera glycines

Anti-tumor drug candidate 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole induces single-strand breaks and DNA-protein cross-links in sensitive MCF-7 breast cancer cells

Total and semisynthesis and in vitro studies of both enantiomers of 20-fluorocamptothecin

Repair of Topoisomerase I‐Mediated DNA Damage

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