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Modelling epilepsy in the mouse: challenges and solutions

Disease models & mechanisms, 2021-03, Vol.14 (3)

2021

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The Unexpected Roles of Eukaryotic Translation Elongation Factors in RNA Virus Replication and Pathogenesis

Microbiology and Molecular Biology Reviews, 2013-06, Vol.77 (2), p.253-266

2013

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The translation elongation factor eEF1A1 couples transcription to translation during heat shock response

eLife, 2014-09, Vol.3, p.e03164

2014

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Face-valid phenotypes in a mouse model of the most common mutation in EEF1A2-related neurodevelopmental disorder

Disease models & mechanisms, 2024-06, Vol.17 (6)

2024

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Translation elongation factor 1A2 is encoded by one of four closely related eef1a genes and is dispensable for survival in zebrafish

Bioscience reports, 2020-01, Vol.40 (1)

2020

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Characterisation of translation elongation factor eEF1B subunit expression in mammalian cells and tissues and co-localisation with eEF1A2

PloS one, 2014-12, Vol.9 (12), p.e114117-e114117

2014

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Eukaryotic elongation factor 1 complex subunits are critical HIV-1 reverse transcription cofactors

Proceedings of the National Academy of Sciences - PNAS, 2012-06, Vol.109 (24), p.9587-9592

2012

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Structural models of human eEF1A1 and eEF1A2 reveal two distinct surface clusters of sequence variation and potential differences in phosphorylation

PloS one, 2009-07, Vol.4 (7), p.e6315

2009

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The role of translation elongation factor eEF1 subunits in neurodevelopmental disorders

Human mutation, 2019-02, Vol.40 (2), p.131-141

2019

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Specific Interaction between eEF1A and HIV RT Is Critical for HIV-1 Reverse Transcription and a Potential Anti-HIV Target

PLoS pathogens, 2015-12, Vol.11 (12), p.e1005289-e1005289

2015

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Eef1a2 promotes cell growth, inhibits apoptosis and activates JAK/STAT and AKT signaling in mouse plasmacytomas

PloS one, 2010-05, Vol.5 (5), p.e10755-e10755

2010

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Translation elongation factor eEF1A2 is a potential oncoprotein that is overexpressed in two-thirds of breast tumours

BMC cancer, 2005-09, Vol.5 (1), p.113-113, Article 113

2005

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eEF1A2 and neuronal degeneration

Biochemical Society transactions, 2009-12, Vol.37 (Pt 6), p.1293

2009

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Endogenous epitope tagging of eEF1A2 in mice reveals early embryonic expression of eEF1A2 and subcellular compartmentalisation of neuronal eEF1A1 and eEF1A2

Molecular and cellular neuroscience, 2023-09, Vol.126, p.103879-103879, Article 103879

2023

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Efficient and versatile CRISPR engineering of human neurons in culture to model neurological disorders

Wellcome open research, 2016-11, Vol.1, p.13-13

2016

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The Cajal Embroidery Project: celebrating neuroscience

Lancet neurology, 2020-12, Vol.19 (12), p.979-979

2020

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Precision Medicine in EpilepsyThe Way Forward?

ACS chemical neuroscience, 2019-04, Vol.10 (4), p.2080-2081

Abbott, Catherine M

2019

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Evolutionary importance of translation elongation factor eEF1A variant switching: eEF1A1 down-regulation in muscle is conserved in Xenopus but is controlled at a post-transcriptional level

Biochemical and biophysical research communications, 2011-07, Vol.411 (1), p.19-24

2011

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Haploinsufficiency for translation elongation factor eEF1A2 in aged mouse muscle and neurons is compatible with normal function

PloS one, 2012-07, Vol.7 (7), p.e41917-e41917

2012

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eEF1A demonstrates paralog specific effects on HIV-1 reverse transcription efficiency

Virology (New York, N.Y.), 2019-04, Vol.530, p.65-74

2019

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eEF1A2 promotes PTEN-GSK3β-SCF complex-dependent degradation of Aurora kinase A and is inactivated in breast cancer

Science signaling, 2024-03, Vol.17 (826), p.eadh4475

2024

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Recapitulation of the EEF1A2 D252H neurodevelopmental disorder-causing missense mutation in mice reveals a toxic gain of function

Human molecular genetics, 2020-06, Vol.29 (10), p.1592-1606

2020

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Loss of SORCS2 is Associated with Neuronal DNA Double-Strand Breaks

Cellular and molecular neurobiology, 2023-01, Vol.43 (1), p.237-249

2023

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Biallelic mutations in the gene encoding eEF1A2 cause seizures and sudden death in F0 mice

Scientific reports, 2017-04, Vol.7 (1), p.46019-46019, Article 46019

2017

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Modelling epilepsy in the mouse: challenges and solutions

The Unexpected Roles of Eukaryotic Translation Elongation Factors in RNA Virus Replication and Pathogenesis

The translation elongation factor eEF1A1 couples transcription to translation during heat shock response

Face-valid phenotypes in a mouse model of the most common mutation in EEF1A2-related neurodevelopmental disorder

Translation elongation factor 1A2 is encoded by one of four closely related eef1a genes and is dispensable for survival in zebrafish

Characterisation of translation elongation factor eEF1B subunit expression in mammalian cells and tissues and co-localisation with eEF1A2

Identification and functional modelling of plausibly causative cis-regulatory variants in a highly-selected cohort with X-linked intellectual disability

Eukaryotic elongation factor 1 complex subunits are critical HIV-1 reverse transcription cofactors

Structural models of human eEF1A1 and eEF1A2 reveal two distinct surface clusters of sequence variation and potential differences in phosphorylation

The role of translation elongation factor eEF1 subunits in neurodevelopmental disorders

Specific Interaction between eEF1A and HIV RT Is Critical for HIV-1 Reverse Transcription and a Potential Anti-HIV Target

Eef1a2 promotes cell growth, inhibits apoptosis and activates JAK/STAT and AKT signaling in mouse plasmacytomas

Translation elongation factor eEF1A2 is a potential oncoprotein that is overexpressed in two-thirds of breast tumours

eEF1A2 and neuronal degeneration

Endogenous epitope tagging of eEF1A2 in mice reveals early embryonic expression of eEF1A2 and subcellular compartmentalisation of neuronal eEF1A1 and eEF1A2

Efficient and versatile CRISPR engineering of human neurons in culture to model neurological disorders

The Cajal Embroidery Project: celebrating neuroscience

Precision Medicine in EpilepsyThe Way Forward?

Evolutionary importance of translation elongation factor eEF1A variant switching: eEF1A1 down-regulation in muscle is conserved in Xenopus but is controlled at a post-transcriptional level

Haploinsufficiency for translation elongation factor eEF1A2 in aged mouse muscle and neurons is compatible with normal function

eEF1A demonstrates paralog specific effects on HIV-1 reverse transcription efficiency

eEF1A2 promotes PTEN-GSK3β-SCF complex-dependent degradation of Aurora kinase A and is inactivated in breast cancer

Recapitulation of the EEF1A2 D252H neurodevelopmental disorder-causing missense mutation in mice reveals a toxic gain of function

Loss of SORCS2 is Associated with Neuronal DNA Double-Strand Breaks

Biallelic mutations in the gene encoding eEF1A2 cause seizures and sudden death in F0 mice

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