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Discovery of betrixaban (PRT054021), N-(5-chloropyridin-2-yl)-2-(4-( N, N-dimethylcarbamimidoyl)benzamido)-5-methoxybenzamide, a highly potent, selective, and orally efficacious factor Xa inhibitor

Bioorganic & medicinal chemistry letters, 2009-04, Vol.19 (8), p.2179-2185

2009

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1-(2-Naphthyl)-1H-pyrazole-5-carboxylamides as potent factor xa inhibitors. Part 3: Design, synthesis and sar of orally bioavailable benzamidine-P4 inhibitors

Bioorganic & medicinal chemistry letters, 2004-03, Vol.14 (5), p.1229-1234

2004

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1-(2-Naphthyl)-1H-pyrazole-5-carboxylamides as potent factor xa inhibitors. Part 2: A survey of P4 motifs

Bioorganic & medicinal chemistry letters, 2004-03, Vol.14 (5), p.1221-1227

2004

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Inhibition of purified factor Xa amidolytic activity may not be predictive of inhibition of in vivo thrombosis: implications for identification of therapeutically active inhibitors

Arteriosclerosis, thrombosis, and vascular biology, 2003-06, Vol.23 (6), p.1098

2003

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N, N-Dialkylated 4-(4-arylsulfonylpiperazine-1-carbonyl)-benzamidines and 4-((4-arylsulfonyl)-2-oxo-piperazin-1-ylmethyl)-benzamidines as potent factor Xa inhibitors

Bioorganic & medicinal chemistry letters, 2004-05, Vol.14 (9), p.2073-2078

2004

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Non-Peptide RGD Surrogates Which Mimic a Gly-Asp β-Turn: Potent Antagonists of Platelet Glycoprotein IIb−IIIa

Journal of medicinal chemistry, 1997-06, Vol.40 (13), p.2085-2101

1997

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Fibrinogen Receptor (GPIIb-IIIa) Antagonists Derived from 5,6-Bicyclic Templates. Amidinoindoles, Amidinoindazoles, and Amidinobenzofurans Containing the N-α-Sulfonamide Carboxylic Acid Function as Potent Platelet Aggregation Inhibitors

Journal of medicinal chemistry, 1997-12, Vol.40 (26), p.4308-4318

1997

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1-(2-Naphthyl)-1 H -pyrazole-5-carboxylamides as potent factor Xa inhibitors. Part 3: Design, synthesis and SAR of orally bioavailable benzamidine-P4 inhibitors

Bioorganic & medicinal chemistry letters, 2004-03, Vol.14 (5), p.1229-1234

2004

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Discovery of betrixaban (PRT054021), N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbamimidoyl)benzamido )-5-metho xybenzamide, a highly potent, selective, and orally efficacious factor Xa inhibitor

Bioorganic & medicinal chemistry letters, 2009-04, Vol.19 (8), p.2179-2185

2009

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DNA sequences of promoter regions for the str and spc ribosomal protein operons in E. coli

Cell, 1978-09, Vol.15 (1), p.215-229

1978

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1-(2-Naphthyl)-1 H -pyrazole-5-carboxylamides as potent factor Xa inhibitors. Part 2: A survey of P4 motifs

Bioorganic & medicinal chemistry letters, 2004-03, Vol.14 (5), p.1221-1227

2004

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Use of Conformationally Restricted Benzamidines as Arginine Surrogates in the Design of Platelet GPIIb-IIIa Receptor Antagonists

Journal of medicinal chemistry, 1997-08, Vol.40 (18), p.2843-2857

1997

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Characterization of Human Prorenin Expressed in Mammalian Cells from Cloned cDNA

Proceedings of the National Academy of Sciences - PNAS, 1986-06, Vol.83 (12), p.4114-4118

1986

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In vitro Expression of Escherichia coli Ribosomal Protein Genes: Autogenous Inhibition of Translation

Proceedings of the National Academy of Sciences - PNAS, 1980-04, Vol.77 (4), p.1837-1841

1980

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Platelet glycoprotein IIb–IIIa receptor (GPIIb–IIIa) antagonists derived from amidinoindoles

Bioorganic & medicinal chemistry letters, 1996-01, Vol.6 (1), p.81-86

1996

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Isolation and characterization of a promoter mutant in the str ribosomal protein operon in E. coli

Cell, 1978-09, Vol.15 (1), p.231-236

1978

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Design, synthesis, and SAR of anthranilamide-based factor Xa inhibitors incorporating substituted biphenyl P4 motifs

Bioorganic & medicinal chemistry letters, 2004-02, Vol.14 (4), p.983-987

2004

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Parallel synthesis and structure–activity relationships of a series of highly potent, selective, and neutral factor Xa inhibitors

Bioorganic & medicinal chemistry letters, 2004-08, Vol.14 (15), p.4045-4050

2004

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Discovery of betrixaban (PRT054021), N-(5-chloropyridin-2-yl)-2-(4-( N, N-dimethylcarbamimidoyl)benzamido)-5-methoxybenzamide, a highly potent, selective, and orally efficacious factor Xa inhibitor

1-(2-Naphthyl)-1H-pyrazole-5-carboxylamides as potent factor xa inhibitors. Part 3: Design, synthesis and sar of orally bioavailable benzamidine-P4 inhibitors

1-(2-Naphthyl)-1H-pyrazole-5-carboxylamides as potent factor xa inhibitors. Part 2: A survey of P4 motifs

Inhibition of purified factor Xa amidolytic activity may not be predictive of inhibition of in vivo thrombosis: implications for identification of therapeutically active inhibitors

N, N-Dialkylated 4-(4-arylsulfonylpiperazine-1-carbonyl)-benzamidines and 4-((4-arylsulfonyl)-2-oxo-piperazin-1-ylmethyl)-benzamidines as potent factor Xa inhibitors

Non-Peptide RGD Surrogates Which Mimic a Gly-Asp β-Turn: Potent Antagonists of Platelet Glycoprotein IIb−IIIa

Fibrinogen Receptor (GPIIb-IIIa) Antagonists Derived from 5,6-Bicyclic Templates. Amidinoindoles, Amidinoindazoles, and Amidinobenzofurans Containing the N-α-Sulfonamide Carboxylic Acid Function as Potent Platelet Aggregation Inhibitors

1-(2-Naphthyl)-1 H -pyrazole-5-carboxylamides as potent factor Xa inhibitors. Part 3: Design, synthesis and SAR of orally bioavailable benzamidine-P4 inhibitors

Discovery of betrixaban (PRT054021), N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbamimidoyl)benzamido )-5-metho xybenzamide, a highly potent, selective, and orally efficacious factor Xa inhibitor

DNA sequences of promoter regions for the str and spc ribosomal protein operons in E. coli

1-(2-Naphthyl)-1 H -pyrazole-5-carboxylamides as potent factor Xa inhibitors. Part 2: A survey of P4 motifs

Use of Conformationally Restricted Benzamidines as Arginine Surrogates in the Design of Platelet GPIIb-IIIa Receptor Antagonists

Characterization of Human Prorenin Expressed in Mammalian Cells from Cloned cDNA

In vitro Expression of Escherichia coli Ribosomal Protein Genes: Autogenous Inhibition of Translation

Platelet glycoprotein IIb–IIIa receptor (GPIIb–IIIa) antagonists derived from amidinoindoles

Isolation and characterization of a promoter mutant in the str ribosomal protein operon in E. coli

Design, synthesis, and SAR of anthranilamide-based factor Xa inhibitors incorporating substituted biphenyl P4 motifs

Parallel synthesis and structure–activity relationships of a series of highly potent, selective, and neutral factor Xa inhibitors

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