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Functional coupling of human pancreatic islets and liver spheroids on-a-chip: Towards a novel human ex vivo type 2 diabetes model

Scientific reports, 2017-11, Vol.7 (1), p.14620-11, Article 14620

2017

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Evaluation of HepaRG cells as an in vitro model for human drug metabolism studies

Drug metabolism and disposition, 2008-07, Vol.36 (7), p.1444-1452

2008

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The TM6SF2 E167K genetic variant induces lipid biosynthesis and reduces apolipoprotein B secretion in human hepatic 3D spheroids

Scientific reports, 2019-08, Vol.9 (1), p.11585-11585, Article 11585

2019

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Primary Human Hepatocyte Spheroid Model as a 3D In Vitro Platform for Metabolism Studies

Journal of pharmaceutical sciences, 2021-01, Vol.110 (1), p.422-431

2021

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Critical differences in drug metabolic properties of human hepatic cellular models, including primary human hepatocytes, stem cell derived hepatocytes, and hepatoma cell lines

Biochemical pharmacology, 2018-09, Vol.155, p.124-140

2018

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Long-term chronic toxicity testing using human pluripotent stem cell-derived hepatocytes

Drug metabolism and disposition, 2014-09, Vol.42 (9), p.1401-1406

2014

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Variability in Mass Spectrometry-based Quantification of Clinically Relevant Drug Transporters and Drug Metabolizing Enzymes

Molecular pharmaceutics, 2017-09, Vol.14 (9), p.3142-3151

2017

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Massive rearrangements of cellular MicroRNA signatures are key drivers of hepatocyte dedifferentiation

Hepatology (Baltimore, Md.), 2016-11, Vol.64 (5), p.1743-1756

2016

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HepaRG cells as an in vitro model for evaluation of cytochrome P450 induction in humans

Drug metabolism and disposition, 2008-01, Vol.36 (1), p.137-145

2008

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Clinically Relevant Cytochrome P450 3A4 Induction Mechanisms and Drug Screening in Three‐Dimensional Spheroid Cultures of Primary Human Hepatocytes

Clinical pharmacology and therapeutics, 2020-10, Vol.108 (4), p.844-855

2020

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Integrated experimental-computational analysis of a HepaRG liver-islet microphysiological system for human-centric diabetes research

PLoS computational biology, 2022-10, Vol.18 (10), p.e1010587-e1010587

2022

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Comparison of inhibitory effects of the proton pump-inhibiting drugs omeprazole, esomeprazole, lansoprazole, pantoprazole, and rabeprazole on human cytochrome P450 activities

Drug metabolism and disposition, 2004-08, Vol.32 (8), p.821-827

2004

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Validation of in vitro methods for human cytochrome P450 enzyme induction: Outcome of a multi-laboratory study

Toxicology in vitro, 2019-10, Vol.60, p.212-228

2019

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Managing the Risk of CYP3A Induction in Drug Development: A Strategic Approach

Drug metabolism and disposition, 2017-01, Vol.45 (1), p.35-41

2017

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Human hepatocytes and cytochrome P450‐selective inhibitors predict variability in human drug exposure more accurately than human recombinant P450s

British journal of pharmacology, 2018-06, Vol.175 (11), p.2116-2129

2018

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Drug metabolizing enzyme and transporter protein profiles of hepatocytes derived from human embryonic and induced pluripotent stem cells

Biochemical pharmacology, 2013-09, Vol.86 (5), p.691-702

2013

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Short‐ and long‐term effects of body weight loss following calorie restriction and gastric bypass on CYP3A‐activity – a non‐randomized three‐armed controlled trial

Clinical and translational science, 2022-01, Vol.15 (1), p.221-233

2022

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In vitro evaluation of major in vivo drug metabolic pathways using primary human hepatocytes and HepaRG cells in suspension and a dynamic three-dimensional bioreactor system

The Journal of pharmacology and experimental therapeutics, 2012-10, Vol.343 (1), p.134-144

2012

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Comparative transcriptomics of hepatic differentiation of human pluripotent stem cells and adult human liver tissue

Physiological genomics, 2017-08, Vol.49 (8), p.430-446

2017

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Bile canaliculi formation and biliary transport in 3D sandwich-cultured hepatocytes in dependence of the extracellular matrix composition

Archives of toxicology, 2016-10, Vol.90 (10), p.2497-2511

2016

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Functional ATP-binding cassette drug efflux transporters in isolated human and rat hepatocytes significantly affect assessment of drug disposition

Drug metabolism and disposition, 2014-03, Vol.42 (3), p.448-458

2014

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Global variability analysis of mRNA and protein concentrations across and within human tissues

NAR genomics and bioinformatics, 2020-03, Vol.2 (1)

2020

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Critical differences in toxicity mechanisms in induced pluripotent stem cell-derived hepatocytes, hepatic cell lines and primary hepatocytes

Archives of toxicology, 2014-07, Vol.88 (7), p.1427-1437

2014

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Evolution of Novel 3D Culture Systems for Studies of Human Liver Function and Assessments of the Hepatotoxicity of Drugs and Drug Candidates

Basic & clinical pharmacology & toxicology, 2017-10, Vol.121 (4), p.234-238

Andersson, Tommy B.

2017

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Amidoxime Reductase System Containing Cytochrome b5 Type B (CYB5B) and MOSC2 Is of Importance for Lipid Synthesis in Adipocyte Mitochondria

The Journal of biological chemistry, 2012-02, Vol.287 (9), p.6307-6317

2012

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Functional coupling of human pancreatic islets and liver spheroids on-a-chip: Towards a novel human ex vivo type 2 diabetes model

Evaluation of HepaRG cells as an in vitro model for human drug metabolism studies

The TM6SF2 E167K genetic variant induces lipid biosynthesis and reduces apolipoprotein B secretion in human hepatic 3D spheroids

Primary Human Hepatocyte Spheroid Model as a 3D In Vitro Platform for Metabolism Studies

Critical differences in drug metabolic properties of human hepatic cellular models, including primary human hepatocytes, stem cell derived hepatocytes, and hepatoma cell lines

Long-term chronic toxicity testing using human pluripotent stem cell-derived hepatocytes

Variability in Mass Spectrometry-based Quantification of Clinically Relevant Drug Transporters and Drug Metabolizing Enzymes

Massive rearrangements of cellular MicroRNA signatures are key drivers of hepatocyte dedifferentiation

HepaRG cells as an in vitro model for evaluation of cytochrome P450 induction in humans

Clinically Relevant Cytochrome P450 3A4 Induction Mechanisms and Drug Screening in Three‐Dimensional Spheroid Cultures of Primary Human Hepatocytes

Integrated experimental-computational analysis of a HepaRG liver-islet microphysiological system for human-centric diabetes research

Comparison of inhibitory effects of the proton pump-inhibiting drugs omeprazole, esomeprazole, lansoprazole, pantoprazole, and rabeprazole on human cytochrome P450 activities

Validation of in vitro methods for human cytochrome P450 enzyme induction: Outcome of a multi-laboratory study

Managing the Risk of CYP3A Induction in Drug Development: A Strategic Approach

Human hepatocytes and cytochrome P450‐selective inhibitors predict variability in human drug exposure more accurately than human recombinant P450s

Drug metabolizing enzyme and transporter protein profiles of hepatocytes derived from human embryonic and induced pluripotent stem cells

Short‐ and long‐term effects of body weight loss following calorie restriction and gastric bypass on CYP3A‐activity – a non‐randomized three‐armed controlled trial

In vitro evaluation of major in vivo drug metabolic pathways using primary human hepatocytes and HepaRG cells in suspension and a dynamic three-dimensional bioreactor system

Comparative transcriptomics of hepatic differentiation of human pluripotent stem cells and adult human liver tissue

Bile canaliculi formation and biliary transport in 3D sandwich-cultured hepatocytes in dependence of the extracellular matrix composition

Functional ATP-binding cassette drug efflux transporters in isolated human and rat hepatocytes significantly affect assessment of drug disposition

Global variability analysis of mRNA and protein concentrations across and within human tissues

Critical differences in toxicity mechanisms in induced pluripotent stem cell-derived hepatocytes, hepatic cell lines and primary hepatocytes

Evolution of Novel 3D Culture Systems for Studies of Human Liver Function and Assessments of the Hepatotoxicity of Drugs and Drug Candidates

Amidoxime Reductase System Containing Cytochrome b5 Type B (CYB5B) and MOSC2 Is of Importance for Lipid Synthesis in Adipocyte Mitochondria

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