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Unexpected Single-Ligand Occupancy and Negative Cooperativity in the SARS-CoV‑2 Main Protease

Journal of chemical information and modeling, 2024-02, Vol.64 (3), p.892-904

2024

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ARN25068, a versatile starting point towards triple GSK-3β/FYN/DYRK1A inhibitors to tackle tau-related neurological disorders

European journal of medicinal chemistry, 2022-02, Vol.229, p.114054-114054, Article 114054

2022

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Comparative analysis of fusion tags used to functionalize recombinant antibodies

Protein expression and purification, 2020-02, Vol.166, p.105505-105505, Article 105505

2020

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An anti-HER2 nanobody binds to its antigen HER2 via two independent paratopes

International journal of biological macromolecules, 2021-07, Vol.182, p.502-511

2021

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Molecular Bases of PDE4D Inhibition by Memory-Enhancing GEBR Library Compounds

Biochemistry (Easton), 2018-05, Vol.57 (19), p.2876-2888

2018

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Engineering methionine γ-lyase from Citrobacter freundii for anticancer activity

Biochimica et biophysica acta. Proteins and proteomics, 2018-12, Vol.1866 (12), p.1260-1270

2018

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1,4,5,6-Tetrahydropyrrolo[3,4-c]pyrazoles: Identification of a Potent Aurora Kinase Inhibitor with a Favorable Antitumor Kinase Inhibition Profile

Journal of medicinal chemistry, 2006-11, Vol.49 (24), p.7247-7251

2006

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A Triazolotriazine‐Based Dual GSK‐3β/CK‐1δ Ligand as a Potential Neuroprotective Agent Presenting Two Different Mechanisms of Enzymatic Inhibition

ChemMedChem, 2019-02, Vol.14 (3), p.310-314

2019

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A Blueprint for High Affinity SARS-CoV‑2 Mpro Inhibitors from Activity-Based Compound Library Screening Guided by Analysis of Protein Dynamics

ACS pharmacology & translational science, 2021-06, Vol.4 (3), p.1079-1095

2021

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Baculovirus-driven protein expression in insect cells: A benchmarking study

Journal of structural biology, 2018-08, Vol.203 (2), p.71-80

2018

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The Role of Structural Biology Task Force: Validation of the Binding Mode of Repurposed Drugs Against SARS-CoV-2 Protein Targets: Focus on SARS-CoV-2 Main Protease (Mpro): A Promising Target for COVID-19 Treatment

Exscalate4CoV, 2023, p.51-59

2023

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Structure–Activity Relationships of Hexahydrocyclopenta[c]quinoline Derivatives as Allosteric Inhibitors of CDK2 and EGFR

ChemMedChem, 2018-12, Vol.13 (24), p.2627-2634

2018

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Easy access to α-ketoamides as SARS-CoV-2 and MERS M pro inhibitors via the PADAM oxidation route

European journal of medicinal chemistry, 2022-12, Vol.244, p.114853

2022

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Investigational Studies on a Hit Compound Cyclopropane–Carboxylic Acid Derivative Targeting O‑Acetylserine Sulfhydrylase as a Colistin Adjuvant

ACS infectious diseases, 2021-02, Vol.7 (2), p.281-292

2021

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Identification of 4,5-Dihydro-1 H -pyrazolo[4,3- h ]quinazoline Derivatives as a New Class of Orally and Selective Polo-Like Kinase 1 Inhibitors

Journal of medicinal chemistry, 2010-05, Vol.53 (9), p.3532-3551

2010

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Fourier transform infrared microspectroscopy reveals biochemical changes associated with glioma stem cell differentiation

Biophysical chemistry, 2015-12, Vol.207, p.90-96

2015

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Potent and Selective Aurora Inhibitors Identified by the Expansion of a Novel Scaffold for Protein Kinase Inhibition

Journal of medicinal chemistry, 2005-04, Vol.48 (8), p.3080-3084

2005

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Topoisomerase IIβ mediates the resistance of glioblastoma stem cells to replication stress-inducing drugs

Cancer cell international, 2016-07, Vol.16 (1), p.58-58, Article 58

2016

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Further insights into the assessment of cell cycle phases by FTIR microspectroscopy

Vibrational spectroscopy, 2014-11, Vol.75, p.127-135

2014

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Abstract B61: Bcr-Abl1 V304D mutation in CML: friend or foe?

Molecular cancer therapeutics, 2015-12, Vol.14 (12_Supplement_2), p.B61-B61

2015

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Structures of γ-Aminobutyric Acid (GABA) Aminotransferase, a Pyridoxal 5′-Phosphate, and [2Fe-2S] Cluster-containing Enzyme, Complexed with γ-Ethynyl-GABA and with the Antiepilepsy Drug Vigabatrin

The Journal of biological chemistry, 2004-01, Vol.279 (1), p.363-373

2004

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Abstract B277: Polymutant BCR-ABL1 proteins during chronic myeloid leukemia therapy: Novel mechanisms of resitance from clinical, in vitro, and in silico evidence

Molecular cancer therapeutics, 2013-11, Vol.12 (11_Supplement), p.B277-B277

2013

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CDNA cloning of the neutrophil bactericidal peptide indolicidin

Biochemical and biophysical research communications, 1992-08, Vol.187 (1), p.467-472

1992

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From protein structure to function via single crystal optical spectroscopy

Frontiers in molecular biosciences, 2015-04, Vol.2, p.12-12

2015

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Thieno[3,2- c]pyrazoles: A novel class of Aurora inhibitors with favorable antitumor activity

Bioorganic & medicinal chemistry, 2010-10, Vol.18 (19), p.7113-7120

2010

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Unexpected Single-Ligand Occupancy and Negative Cooperativity in the SARS-CoV‑2 Main Protease

ARN25068, a versatile starting point towards triple GSK-3β/FYN/DYRK1A inhibitors to tackle tau-related neurological disorders

Comparative analysis of fusion tags used to functionalize recombinant antibodies

An anti-HER2 nanobody binds to its antigen HER2 via two independent paratopes

Molecular Bases of PDE4D Inhibition by Memory-Enhancing GEBR Library Compounds

Engineering methionine γ-lyase from Citrobacter freundii for anticancer activity

1,4,5,6-Tetrahydropyrrolo[3,4-c]pyrazoles: Identification of a Potent Aurora Kinase Inhibitor with a Favorable Antitumor Kinase Inhibition Profile

A Triazolotriazine‐Based Dual GSK‐3β/CK‐1δ Ligand as a Potential Neuroprotective Agent Presenting Two Different Mechanisms of Enzymatic Inhibition

A Blueprint for High Affinity SARS-CoV‑2 Mpro Inhibitors from Activity-Based Compound Library Screening Guided by Analysis of Protein Dynamics

Baculovirus-driven protein expression in insect cells: A benchmarking study

The Role of Structural Biology Task Force: Validation of the Binding Mode of Repurposed Drugs Against SARS-CoV-2 Protein Targets: Focus on SARS-CoV-2 Main Protease (Mpro): A Promising Target for COVID-19 Treatment

Structure–Activity Relationships of Hexahydrocyclopenta[c]quinoline Derivatives as Allosteric Inhibitors of CDK2 and EGFR

Easy access to α-ketoamides as SARS-CoV-2 and MERS M pro inhibitors via the PADAM oxidation route

Investigational Studies on a Hit Compound Cyclopropane–Carboxylic Acid Derivative Targeting O‑Acetylserine Sulfhydrylase as a Colistin Adjuvant

Identification of 4,5-Dihydro-1 H -pyrazolo[4,3- h ]quinazoline Derivatives as a New Class of Orally and Selective Polo-Like Kinase 1 Inhibitors

Fourier transform infrared microspectroscopy reveals biochemical changes associated with glioma stem cell differentiation

Potent and Selective Aurora Inhibitors Identified by the Expansion of a Novel Scaffold for Protein Kinase Inhibition

Topoisomerase IIβ mediates the resistance of glioblastoma stem cells to replication stress-inducing drugs

Further insights into the assessment of cell cycle phases by FTIR microspectroscopy

Abstract B61: Bcr-Abl1 V304D mutation in CML: friend or foe?

Structures of γ-Aminobutyric Acid (GABA) Aminotransferase, a Pyridoxal 5′-Phosphate, and [2Fe-2S] Cluster-containing Enzyme, Complexed with γ-Ethynyl-GABA and with the Antiepilepsy Drug Vigabatrin

Abstract B277: Polymutant BCR-ABL1 proteins during chronic myeloid leukemia therapy: Novel mechanisms of resitance from clinical, in vitro, and in silico evidence

CDNA cloning of the neutrophil bactericidal peptide indolicidin

From protein structure to function via single crystal optical spectroscopy

Thieno[3,2- c]pyrazoles: A novel class of Aurora inhibitors with favorable antitumor activity

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